Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Glycosylation of T helper cell proteins in autoimmune thyroid diseases: characteristic of changes during the course of diseases and the role of cytokines in glycosylation regulation

2015/18/E/NZ6/00602

Keywords:

glycosylation T helper cells autoimmune thyroid diseases cytokines glycosylotransferases N-glycans

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ3_1: Cell biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Pocheć 

Number of co-investigators in the project: 7

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 658 960 PLN

Project start date (Y-m-d): 2016-05-13

Project end date (Y-m-d): 2023-11-12

Project duration:: 90 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny sorter magnetyczny (245 000 PLN)
  2. Licencja na oprogramowanie firmy Microsoft.
  3. Licencja wieczysta dwustanowiskowa na program do analizy statystycznej GraphPad Prism 9 (6 061 PLN)
  4. zamrażarka niskotemperaturowa.
  5. Inkubator CO2 (33 000 PLN)
  6. Komora laminarna II klasy bezpieczeństwa z pionowym przepływem powietrza (37 000 PLN)
  7. urządzenie wielofunkcyjne.
  8. Komputer przenośny (laptop).
  9. Mikser do próbek z magnesem (7 000 PLN)
  10. Komputer przenośny (laptop) (5 965 PLN)
  11. Naczynie dewara do przechowywania zamrożonych komórek (10 000 PLN)
  12. Sprzęt do elektroforezy SDS-PAGE i Western blottigu (13 357 PLN)
  13. łaźnia wodna.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (15)
  • Book publications / chapters in book publications (1)
  1. Glycosylation in the Thyroid Gland: Vital Aspects of Glycoprotein Function in Thyrocyte Physiology and Thyroid Disorders.
    Authors:
    Ząbczyńska Marta, Kozłowska Kamila, Pocheć Ewa
    Academic press:
    Int J Mol Sci (rok: 2018, tom: 19(9), strony: pii: E2792), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19092792 - link to the publication
  2. Glikoproteiny układu odpornościowego: struktura i funkcja części cukrowej wybranych receptorów błonowych limfocytów T. Część I.
    Authors:
    Katarzyna Polak, Ewa Pocheć
    Academic press:
    Postępy Biologii Komórki (rok: 2017, tom: 44(2), strony: 185-200), Wydawca: Fundacja Biologii Komórki i Biologii Molekularnej
    Status:
    Published
    DOI:
    brak - link to the publication
  3. The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto's Thyroiditis: An in Vitro Model of Thyroid Autoimmunity.
    Authors:
    Marta Ząbczyńska, Katarzyna Polak, Kamila Kozłowska, Grzegorz Sokołowski, Ewa Pocheć
    Academic press:
    Biomolecules (rok: 2020, tom: 10(2), strony: pii: E171), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10020171 - link to the publication
  4. The role of N-glycosylation in B-cell biology and IgG activity. The aspects of autoimmunity and anti-inflammatory therapy
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Ewa Pocheć
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14, strony: 1188838), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1188838 - link to the publication
  5. Altered N-glycan profile of IgG-depleted serum proteins in Hashimoto's thyroiditis.
    Authors:
    Marta Ząbczyńska, Paweł Link-Lenczowski, Mislav Novokmet, Tiphanie Martin, Renata Turek-Jabrocka, Małgorzata Trofimiuk-Müldner, Ewa Pocheć
    Academic press:
    Biochim Biophys Acta Gen Subj. (rok: 2020, tom: 1864(3), strony: 129464), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagen.2019.129464 - link to the publication
  6. Changes of IgG N-Glycosylation in Thyroid Autoimmunity: The Modulatory Effect of Methimazole in Graves' Disease and the Association With the Severity of Inflammation in Hashimoto's Thyroiditis
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Grzegorz Sokołowski, Ewa Pocheć
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 841710), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.841710 - link to the publication
  7. Glikoproteiny układu odpornościowego: rola glikanów antygenów zgodności tkankowej (MHC) oraz znaczenie galektyn w aktywacji i apoptozie limfocytów T. Część II.
    Authors:
    Katarzyna Polak, Ewa Pocheć
    Academic press:
    Postępy Biologii Komórki (rok: 2017, tom: 44(3), strony: 251-272), Wydawca: Fundacja Biologii Komórki i Biologii Molekularnej
    Status:
    Published
    DOI:
    brak - link to the publication
  1. N-glycome of PBMC CD4- changes in Graves' disease
    Authors:
    Jakub Godziek, Paweł Link-Lenczowski, Sara Trzos, Marta Ząbczyńska, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    26th Gliwice Scientific Meetings (rok: 2022, ), Wydawca: Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch; Association for the Support of Cancer Research, Silesian University of Technology
    Data:
    konferencja 18-19.11.2022
    Status:
    Published
  2. N-glycosylation of CD4+ T cells is altered in autoimmune thyroid diseases
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    46th FEBS Congress (rok: 2022, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 9-14.07.2022
    Status:
    Published
  3. N-glycosylation of IgG reflects the severity of inflammation in Hashimoto's thyroiditis
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    25th Gliwice Scientific Meetings (rok: 2021, ), Wydawca: Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch; Association for the Support of Cancer Research; Silesian University of Technology
    Data:
    konferencja 2021.11.18-20
    Status:
    Published
  4. The link between serum cytokines levels and N-glycosylation of CD4+ T cells in Graves' disease
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Maria Piórkowska, Grzegorz Sokołowski, Katarzyna Bocian, Ewa Pocheć
    Conference:
    Paths of Glycobiology. Jerzy Kościelak Memorial Conference (rok: 2023, ), Wydawca: Hirszfeld Institute of Immunology and Experimental Therapy and Wrocław University of Enviromental and Life Sciences
    Data:
    konferencja 28-29.09.2023
    Status:
    Published
  5. Altered expression of T cell glycosyltransferases in Graves' disease
    Authors:
    Marta Ząbczyńska, Anna Chojnacka, Paulina Korta, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  6. C-reactive protein in Graves' disease
    Authors:
    Sara Trzos, Karolina Królik, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    XXIX International Symposium Molecular and Physiological Aspects of Regulatory Processes in the Organism, Kraków (rok: 2022, ), Wydawca: Biological Commission, Polish Academy of Sciences
    Data:
    konferencja 8-9.10.2022
    Status:
    Published
  7. Characteristics of CD4+ T cell N-glycans in Hashimoto's thyroiditis
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    4th Central European Biomedical Congress (rok: 2021, ), Wydawca: Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
    Data:
    konferencja 2021.06.7-9
    Status:
    Published
  8. Fucosylation of IgG in Graves' disease
    Authors:
    Sara Trzos, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    6th International Conference of Cell Biology (rok: 2020, ), Wydawca: Jagiellonian University in Krakow
    Data:
    konferencja 2020-11-6-8
    Status:
    Published
  9. The expression of glycosyltransferases is changed in CD4+ T cells in Hashimoto's thyroiditis
    Authors:
    Paulina Korta, Marta Ząbczyńska, Natalia Bajgier, Małgorzata Trofimiuk-Müldner, Ewa Pocheć
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  10. Fucosylation of CD4+CD25+ T cells is implicated in the development of Graves' disease
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    British Society for Immunology Congress (rok: 2022, ), Wydawca: British Society for Immunology
    Data:
    konferencja 5-8.12.2022
    Status:
    Published
    DOI:
    link to the publication
  11. N-glycosylation of CD4+ T cells correlates with TNFα and IL-4 levels in Hashimoto's thyroiditis
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Maria Piórkowska, Grzegorz Sokołowski, Katarzyna Bocian, Ewa Pocheć
    Conference:
    5th Congress of Polish Biosciences BIO2023 (rok: 2023, ), Wydawca: Polish Biochemical Society, Polish Society for Cell Biology, Polish Biophysical Society, Polish Society for Laboratory Diagnostics, Polish Cytometric Society, Polish Mycological Society
    Data:
    konferencja 13-16.09.2023
    Status:
    Published
  12. Does immunosuppressive therapy affect IgG N-glycan structures in Graves' disease?
    Authors:
    Sara Trzos, Paweł Link-Lenczowski, Marta Ząbczyńska, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    XXVIII International Symposium Molecular and Physiological Aspects of Regulatory Processes in the Organism (rok: 2021, ), Wydawca: The Biological Committee of the Krakow Division of the Polish Academy of Sciences, Cracow, Poland
    Data:
    konferencja 44457
    Status:
    Published
  13. Optimization of CD4+CD25+ T cell isolation from human blood: the difference in the content of activated T-helper cells between Hashimoto's thyroidits and healthy donors
    Authors:
    Marta Ząbczyńska, Katarzyna Polak, Kamila Kozłowska, Katarzyna Bocian, Grzegorz Sokołowski, Małgorzata Trofimiuk-Mȕldner, Ewa Pocheć
    Conference:
    XXVI International Symposium Molecular and Physiological Aspects of Regulatory Processes of the Organism (rok: 2017, ), Wydawca: Joseph Dietl Malopolska Higher School in Cracow
    Data:
    konferencja 16.09.2017
    Status:
    Published
  14. Sialylation of serum proteins in Graves' disease
    Authors:
    Sara Trzos, Joanna Bilska, Paweł Link-Lenczowski, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    47th FEBS Congress (rok: 2023, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 8-12.07.2023
    Status:
    Published
  15. Studies on N-glycosylation of C-reactive protein in the course of Graves' disease
    Authors:
    Sara Trzos, Karolina Królik, Paweł Link-Lenczowski, Grzegorz Sokołowski, Ewa Pocheć
    Conference:
    27th Gliwice Scientific Meetings (rok: 2023, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Silesian University of Technology
    Data:
    konferencja 16-17.11.2023
    Status:
    Published
  1. Glycosylation in autoimmune diseases
    Authors:
    Marta Ząbczyńska, Paweł Link-Lenczowski, Ewa Pocheć
    Book:
    The Role of Glycosylation in Health and Disease (rok: 2021, tom: 1325, strony: 205-218), Wydawca: Springer
    Status:
    Published

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