Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Antiapoptotc activity of human fibroblast growth factors 1 and 2

2015/18/E/NZ3/00501

Keywords:

FGF1 FGF2 apoptosis protection properties protein-protein interaction

Descriptors:

  • NZ1_2: Biochemistry
  • NZ3_1: Cell biology
  • NZ3_3: Apoptosis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Zakrzewska 

Number of co-investigators in the project: 12

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 2 170 200 PLN

Project start date (Y-m-d): 2016-04-18

Project end date (Y-m-d): 2021-11-17

Project duration:: 67 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 (85 000 PLN)
  2. Mikroskop fluorescencyjny odwrócony do rejestracji obrazów komórek z możliwością obserwacji w świetle przechodzącym oraz kontraście fazowym (210 000 PLN)
  3. Wysokosprawny chromatograf cieczowy (FPLC) (260 000 PLN)

Information in the final report

  • Publication in academic press/journals (16)
  • Articles in post-conference publications (15)
  1. Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation
    Authors:
    Krzyscik MA, Sokolowska-Wedzina A, Jendryczko K, Pozniak M, Nawrocka D, Porebska N, Zakrzewska M, Otlewski J, Szlachcic A, Opalinski L.
    Academic press:
    Journal of Visualized Experiments (rok: 2021, tom: Jan 5;(167), strony: -167), Wydawca: MyJove Corp.
    Status:
    Published
    DOI:
    10.3791/61918 - link to the publication
  2. Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment.
    Authors:
    Porębska N, Latko M, Kucińska M, Zakrzewska M, Otlewski J, Opaliński Ł.
    Academic press:
    Journal of Clinical Medicine (rok: 2019, tom: 8(1), strony: pii:E7), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm8010007 - link to the publication
  3. Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling.
    Authors:
    Zakrzewska, M.; Opalinski, L.; Haugsten, E.M.; Otlewski, J.; Wiedlocha, A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(8), strony: E1826), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20081826 - link to the publication
  4. Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)
    Authors:
    Krzyścik M, Zakrzewska M, Otlewski J
    Academic press:
    Molecular Pharmaceutics (rok: 2020, tom: 17 (7), strony: 2734–2748), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.0c00419 - link to the publication
  5. Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.
    Authors:
    Kucinska, M.; Porebska, N.; Lampart, A.; Latko, M.; Knapik, A.; Zakrzewska, M.; Otlewski, J. Opalinski, L.
    Academic press:
    Cell Communication and Signaling (rok: 2019, tom: 17(1), strony: 65), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-019-0371-1 - link to the publication
  6. Nuclear localization sequence of FGF1 is not required for its intracellular anti-apoptotic activity in differentiated cells
    Authors:
    Lampart A., Sluzalska K., Czyrek A., Szerszen A., Otlewski J., Wiedlocha A., Zakrzewska M.
    Academic press:
    Cells (rok: 2022, tom: Feb 2;11(3), strony: 522), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11030522 - link to the publication
  7. Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential
    Authors:
    Nawrocka D, Krzyścik M, Opaliński Ł, Zakrzewska M, Otlewski J
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(11):4108, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21114108 - link to the publication
  8. Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins.
    Authors:
    Latko, M.; Czyrek, A.; Porebska, N.; Kucinska, M.; Otlewski, J.; Zakrzewska, M.; Opalinski, L.
    Academic press:
    Cells (rok: 2019, tom: 8(5), strony: E455), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8050455 - link to the publication
  9. FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner
    Authors:
    Sochacka, M, Opaliński Ł, Szymczyk J, Zimoch M, Czyrek A, Krowarsch D, Otlewski J, Zakrzewska M
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 18(1):69, strony: 45302), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-020-00573-2 - link to the publication
  10. Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions
    Authors:
    Sluzalska K, Slawski J, Sochacka M, Lampart A, Otlewski J, Zakrzewska M
    Academic press:
    Cytokine & Growth Factor Reviews (rok: 2021, tom: 57, strony: 93-111), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2020.05.004 - link to the publication
  11. Roles of the FGF-FGFR Signaling System in Cancer Development and Inflammation
    Authors:
    Wiedlocha A., Haugsten EM., Zakrzewska M.
    Academic press:
    Cells (rok: 2021, tom: Aug 28;10(9), strony: 2231), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092231 - link to the publication
  12. Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation.
    Authors:
    Kostas M, Lampart A, Bober J, Wiedlocha A, Tomala J, Krowarsch D, Otlewski J, Zakrzewska M.
    Academic press:
    Journal of Molecular Biology (rok: 2018, tom: 430(21), strony: 4087-4101), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmb.2018.08.004 - link to the publication
  13. Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1
    Authors:
    Porebska N, Pozniak M, Krzyscik MA, Knapik A, Czyrek A, Kucinska M, Jastrzebski K, Zakrzewska M, Otlewski J, Opalinski L
    Academic press:
    International Journal of Biological Macromolecules (rok: 2021, tom: Jun 1;180, strony: 470-483), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2021.03.094. - link to the publication
  14. FGF/FGFR-Dependent Molecular Mechanisms Underlying Anti-Cancer Drug Resistance
    Authors:
    Szymczyk J, Sluzalska K, Materla I, Opalinski L, Otlewski J, Zakrzewska M
    Academic press:
    Cancers (rok: 2021, tom: Nov 18;13(22), strony: 5796), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13225796 - link to the publication
  15. High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1
    Authors:
    Opaliński Ł, Szymczyk J, Szczepara M, Kucińska M, Krowarsch D, Zakrzewska M, Otlewski J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19(5), strony: pii: E1435), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19051435 - link to the publication
  16. Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity.
    Authors:
    Szlachcic, A.; Sochacka, M.; Czyrek, A.; Opalinski, L.; Krowarsch, D.; Otlewski, J.; Zakrzewska, M.
    Academic press:
    Cells (rok: 2019, tom: 8(8), strony: E899), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8080899 - link to the publication
  1. FGF12 is able to activate signaling in cells expressing FGF receptors
    Authors:
    Martyna Sochacka, Lukasz Opalinski, Malgorzata Zakrzewska
    Conference:
    3rd Fibroblast Growth Factors in Development and Repair Conference (rok: 2019, ), Wydawca: Fusion Conferences Ltd
    Data:
    konferencja 2019-02-15-18
    Status:
    Published
  2. Structural instability of FGF1 R50E mutant restricts its mitogenic potential
    Authors:
    A. Czyrek, A. Szlachcic, M. Sochacka, L. Opaliński, J. Otlewski, M. Zakrzewska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS (FEBS OpenBio)
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  3. Antiapoptotic proteins' expression profile upon FGF1 and FGF2 translocation.
    Authors:
    A.M. Lampart, J. Sławski, M. Zakrzewska
    Conference:
    ASCB/EMBO 2017 meeting (rok: 2017, ), Wydawca: ASCB/EMBO
    Data:
    konferencja 2-6 grudnia
    Status:
    Published
  4. FGF1 enhances the cytotoxic activity of honokiol in tumor cells expressing FGFR1
    Authors:
    J. Szymczyk, P. Chudy, I. Materla, M. Zakrzewska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS (FEBS OpenBio)
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  5. FGF1 protects cells against p53-dependent apoptosis independently of FGFR activation
    Authors:
    Agata Lampart, Aleksandra Szerszen, Malgorzata Zakrzewska
    Conference:
    3rd Fibroblast Growth Factors in Development and Repair Conference (rok: 2019, ), Wydawca: Fusion Conferences Ltd
    Data:
    konferencja 2019-02-15-18
    Status:
    Published
  6. Antiapoptotic activity of FGF1 and FGF2 in PC12 cells
    Authors:
    K. Służalska, M. Biaduń, M. Zakrzewska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS (FEBS OpenBio)
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  7. Structural instability of FGF1 R50E mutant restricts its mitogenic potential
    Authors:
    Martyna Szczepara, Anna Szlachcic, Aleksandra Czyrek, Łukasz Opaliński, Jacek Otlewski, Małgorzata Zakrzewska
    Conference:
    Cellular signalling and cancer therapy – EMBO Workshop (rok: 2018, ), Wydawca: EMBO
    Data:
    konferencja 14.09-18.09 2018
    Status:
    Published
  8. Design of fibroblast growth factor 1 for medical applications
    Authors:
    Malgorzata Zakrzewska
    Conference:
    Modeling & Design of Molecular Materials 2016 (rok: 2016, ), Wydawca: Politechnika Wrocławska
    Data:
    konferencja 26-30 czerwca 2016
    Status:
    Published
  9. FGF1 protects tumor cells against taltobulin by activating FGFR1-dependent signaling pathways
    Authors:
    Jakub Szymczyk, Patryk Chudy, Małgorzata Zakrzewska
    Conference:
    Biochemistry Forever – The 43rd FEBS Congress (rok: 2018, ), Wydawca: FEBS
    Data:
    konferencja 7.07-12.07 2018
    Status:
    Published
  10. FGF12 is able to activate signaling in cells expressing FGF receptors
    Authors:
    M. Sochacka, M. Zimoch, L. Opalinski, M. Zakrzewska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS (FEBS OpenBio)
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  11. Regulation of FGFR1 spatial distribution and activity by extracellular galectins
    Authors:
    M. Kucinska, N. Porebska, A. Lampart, M. Latko, A. Knapik, M. Zakrzewska, J. Otlewski, L. Opaliński
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS (FEBS OpenBio)
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  12. The role of FGF1 activity in tumor cells treated with anticancer drugs.
    Authors:
    Patryk Chudy, Jakub Szymczyk, Malgorzata Zakrzewska
    Conference:
    5th International Conference of Cell Biology (rok: 2019, ), Wydawca: -
    Data:
    konferencja 2019-05-10-12
    Status:
    Published
  13. The role of nuclear localization of translocated FGF1 and FGF2 for their antiapoptotic activity
    Authors:
    A.M. Lampart, J. Tomala, J. Sławski, M. Zakrzewska
    Conference:
    ASCB/EMBO 2017 meeting (rok: 2017, ), Wydawca: ASCB/EMBO
    Data:
    konferencja 2-6 grudnia
    Status:
    Published
  14. FGF1 protects cells against p53-dependent apoptosis independently of FGFR activation
    Authors:
    A. Lampart, A. Szerszeń, M. Zakrzewska
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS (FEBS OpenBio)
    Data:
    konferencja 2019-07-06-11
    Status:
    Published
  15. The pro-survival activity of FGF1 and FGF2 in tumor cells treated with taltobulin
    Authors:
    Jakub Szymczyk, Patryk Chudy, Małgorzata Zakrzewska
    Conference:
    Cellular signalling and cancer therapy – EMBO Workshop (rok: 2018, ), Wydawca: EMBO
    Data:
    konferencja 14.09-18.09 2018
    Status:
    Published

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