Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Purine salvage pathway enzymes as a target for pathogenic organisma lacking de novo purine synthesis -cas study of Helicobacter pylori

2015/18/M/NZ1/00776

Keywords:

Helicobacter pylori molecular mechanism of catalysis purine nucleoside phosphorylase adenylosuccinate synthetase salvage pathway

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_3: Biophysics
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bzowska 

Number of co-investigators in the project: 7

Call: HARMONIA 7 - announced on 2015-06-15

Amount awarded: 404 520 PLN

Project start date (Y-m-d): 2016-04-15

Project end date (Y-m-d): 2021-04-14

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori
    Authors:
    Marta Ilona Wojtyś, Radosław Jaźwiec, Saša Kazazić, Ivana Leščić Ašler, Petar Knežević, Verica Aleksić Sabo, Marija Luić, Elżbieta Katarzyna Jagusztyn-Krynicka, Agnieszka Bzowska
    Academic press:
    Applied Microbiology and Biotechnology (rok: 2021, tom: 105, strony: 7949-7967), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00253-021-11510-9 - link to the publication
  2. Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis
    Authors:
    Zoran Štefanić, Marta Narczyk, Goran Mikleušević, Saša Kazazić, Agnieszka Bzowska, Marija Luic
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 15427), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-33723-1 - link to the publication
  3. Structural characterization of purine nucleoside phosphorylase from human pathogen Helicobacter pylori
    Authors:
    Zoran Štefanić, Goran Mikleušević, Marija Luić, Agnieszka Bzowska, Ivana Leščić Ašler
    Academic press:
    International Journal of Biological Macromolecules (rok: 2017, tom: 101, strony: 518-526), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2017.03.101 - link to the publication
  4. Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from Helicobacter pylori in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
    Authors:
    Marta Narczyk, Marta Ilona Wojtyś, Ivana Leščić Ašler, Biserka Žinić, Marija Luić, Elżbieta Katarzyna Jagusztyn-Krynicka, Zoran Štefanić and Agnieszka Bzowska
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry , Wydawca: Taylor&Francis Group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features
    Authors:
    Marta Narczyk, Branimir Bertosa, Lucija Papa, Vedran Vukovic, Ivana Leščić Ašler, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Marija Luić, Zoran Štefanić
    Academic press:
    FEBS Journal (rok: 2018, tom: 285, strony: 1305–1325), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.14403 - link to the publication
  6. In the quest for new targets for pathogen eradication: the adenylosuccinate synthetase from the bacterium Helicobacter pylori
    Authors:
    Ante Bubić, Natalia Mrnjavac, Igor Stuparević, Marta Łyczek, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Marija Luić, Ivana Leščić Ašler
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2018, tom: 33, strony: 1405–1414), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2018.1506773 - link to the publication

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