Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Surface carbohydrate-dependent phages select for resistant bacterial population that become more susceptible to host clearance mechanisms of immune system.

2015/18/M/NZ6/00413

Keywords:

bacteriophage phage resistance pathogenicity surface polysaccharides

Descriptors:

  • NZ6_4: Bacteriology
  • NZ6_5: Virology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zuzanna Drulis-Kawa 

Number of co-investigators in the project: 9

Call: HARMONIA 7 - announced on 2015-06-15

Amount awarded: 1 173 600 PLN

Project start date (Y-m-d): 2016-04-15

Project end date (Y-m-d): 2021-04-14

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. PhREEPred: Phage Resistance Emergence Prediction web to predict bacterial escape from phage cocktail treatment
    Authors:
    Bogna J. Smug, Grazyna Majkowska-Skrobek and Zuzanna Drulis-Kawa
    Academic press:
    Journal of Molecular Biology (rok: 2022, tom: Jul 30;434(14), strony: 167670), Wydawca: Springer Science+Business Media
    Status:
    Published
    DOI:
    10.1016/j.jmb.2022.167670 - link to the publication
  2. Editorial: Bacterial Surface Glycans as the Virulence Agent and the Target for Predators, Therapy, and the Immune System
    Authors:
    Zuzanna Drulis-Kawa
    Academic press:
    Front. Microbiol. (rok: 2020, tom: 11, strony: 11:624964.), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2020.624964 - link to the publication
  3. Genome-driven elucidation of phage-host interplay and impact on bacterial fitness and (pseudo)lysogeny in Pseudomonas aeruginosa
    Authors:
    Pawel Markwitz, Cédric Lood, Tomasz Olszak, Vera van Noort, Rob Lavigne, Zuzanna Drulis-Kawa
    Academic press:
    ISME Journal (rok: 2022, tom: Feb;16(2), strony: 533-542), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41396-021-01096-5 - link to the publication
  4. Phage Life Cycles Behind Bacterial Biodiversity
    Authors:
    Olszak T, Latka A, Roszniowski B, Valvano MA, Drulis-Kawa Z
    Academic press:
    Current Medicinal Chemistry (rok: 2017, tom: Nov 24;24(36), strony: 3987-4001.), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867324666170413100136. - link to the publication
  5. The Mutation in wbaP cps Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of Klebsiella pneumoniae
    Authors:
    Kaszowska, M.; Majkowska-Skrobek, G.; Markwitz, P.; Lood, C.; Jachymek,W.; Maciejewska, A.; Lukasiewicz, J.; Drulis-Kawa, Z.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11562), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111562 - link to the publication
  6. Phage treatment of Pseudomonas aeruginosa yields a phage-resistant population with different susceptibility to innate immune responses and mild effects on metabolic profiles
    Authors:
    Tomasz Olszak, Daria Augustyniak, Inmaculada García-Romero, Pawel Markwitz, Grzegorz Gula, Antonio Molinaro, Miguel A. Valvano, Zuzanna Drulis-Kawa
    Academic press:
    Microbiological Research (rok: 2024, tom: online first, strony: online first), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.micres.2024.127609 - link to the publication
  7. The evolutionary trade-offs in phage-resistant Klebsiella pneumoniae entail cross-phage sensitization and loss of multidrug resistance
    Authors:
    Majkowska-Skrobek G, Markwitz P, Sosnowska E, Lood C, Lavigne R, Drulis-Kawa Z.
    Academic press:
    Environmental Microbiology (rok: 2021, tom: 23(12), strony: 7723–7740), Wydawca: Society for Applied Microbiology and John Wiley & Sons Ltd.,
    Status:
    Published
    DOI:
    10.1111/1462-2920.15476 - link to the publication
  8. Emerging phage resistance in Pseudomonas aeruginosa PAO1 is accompanied by enhanced heterogeneity and reduced virulence
    Authors:
    Pawel Markwitz, Tomasz Olszak, Grzegorz Gula, Magdalena Kowalska, Michal Arabski, and Zuzanna Drulis-Kawa
    Academic press:
    Viruses MDPI (rok: 2021, tom: 13, strony: 1332), Wydawca: MDPI Basel
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  9. Pseudomonas aeruginosa PA5oct Jumbo Phage Impacts Planktonic and Biofilm Population and Reduces Its Host Virulence
    Authors:
    Tomasz Olszak, Katarzyna Danis-Wlodarczyk, Michal Arabski, Grzegorz Gula, Barbara Maciejewska, Slawomir Wasik, Cédric Lood, Gerard Higgins, Brian J. Harvey, Rob Lavigne, Zuzanna Drulis-Kawa
    Academic press:
    Viruses MDPI (rok: 2019, tom: 11, strony: 1089), Wydawca: MDPI Basel
    Status:
    Published
    DOI:
    10.3390/v11121089 - link to the publication

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