Projects funded by the NCN
Characterization of actbl2 - recently discovered actin isoform and its role in migration and invasion of human melanoma cells
2015/17/B/NZ3/03604
Keywords:
actbl2 actin actin isoforms cell migration cell invasion tumor melanoma breast carcinoma prostate carcinoma cell pathology posttranslational modifications
Descriptors:
- NZ3_1: Cell biology
Panel:
NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution :
Uniwersytet Wrocławski, Wydział Biotechnologii
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 9 - announced on 2015-03-16
Amount awarded: 782 180 PLN
Project start date (Y-m-d): 2016-03-09
Project end date (Y-m-d): 2020-03-08
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Termoblok.
- Wytrząsarka do bakterii z funkcją chłodzenia (49 000 PLN)
- Blok chłodzącogrzejny z wytrząszaniem na probówki 1,5-2,0 ml oraz 15 ml probówki typu Falkon® (11 000 PLN)
- komputer stacjonarny.
- Miniwirówka.
- Wirówka stołowa z chłodzeniem + rotory na 1,5-2,0 ml próbówki oraz 15 i 50 ml probówki typu Falkon® (38 000 PLN)
- Duży aparat do elektroforezy białkowej (10 500 PLN)
Information in the final report
- Publication in academic press/journals (4)
- Book publications / chapters in book publications (1)
- Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells' Motility and Focal Adhesion FormationAuthors:Natalia Malek, Ewa Mrówczyńska, Aleksandra Michrowska, Ewa Mazurkiewicz, Iuliia Pavlyk, Antonina Joanna MazurAcademic press:International Journal of Molecular Sciences (rok: 2020, tom: 21(8), strony: 2746), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms21082746 - link to the publication
- Non-muscle actin paralogues and their acting on the cell cycle progression and proliferationAuthors:Estera Jeruzalska, Antonina Joanna MazurAcademic press:European Journal of Cell Biology , Wydawca: ElsevierStatus:SubmittedDOI:brak - link to the publication
- Are non-muscle actin isoforms functionally equivalent ?Authors:Aleksandra Simiczyjew, Katarzyna Pietraszek-Gremplewicz, Antonina Joanna Mazur, Dorota NowakAcademic press:Histology and Histopathology (rok: 2017, tom: 32, strony: 1125-1139), Wydawca: Jiménez-Godoy, S.A. Murcia. SpainStatus:PublishedDOI:10.14670/HH-11-896 - link to the publication
- The origin of the expressed retrotransposed gene ACTBL2 and its influence on human melanoma cells' motility and focal adhesion formationAuthors:Natalia Malek, Aleksandra Michrowska, Ewa Mazurkiewicz, Ewa Mrówczyńska, Paweł Mackiewicz, Antonina J. MazurAcademic press:Scientific Reports (rok: 2021, tom: 11, strony: 3329), Wydawca: Springer NatureStatus:PublishedDOI:10.1038/s41598-021-82074-x - link to the publication
- A Fluorescent Gelatin Degradation Assay to Study Melanoma Breakdown of Extracellular MatrixAuthors:Ewa Mazurkiewicz, Ewa Mrówczyńska, Aleksandra Simiczyjew, Dorota Nowak, Antonina J. MazurBook:"Melanoma - methods and protocols" w serii książek "Methods in molecular biology" (rok: 2021, tom: 2265, strony: 47-63), Wydawca: Springer NatureStatus:Published