Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Crosstalk between vitamin D receptor (VDR) and retinoic acid receptors (RARs) in hematopoiesis.

2015/17/B/NZ4/02632

Keywords:

vitamin D receptor retinoic acid receptors transcriptional regulation hematopoiesis epigenetic control transcription factors

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_1: Cell biology
  • NZ4_3: Comparative physiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Marcinkowska 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 690 000 PLN

Project start date (Y-m-d): 2016-02-08

Project end date (Y-m-d): 2020-08-07

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Regulation of FOXP3 expression in myeloid cells in response to all-transretinoic acid, interleukin 2 and transforming growth factor β
    Authors:
    Aleksandra Ilnicka, Elżbieta Gocek, Justyna Łopatecka, Ewa Marcinkowska
    Academic press:
    Developmental and Comparative Immunology (rok: 2019, tom: 96, strony: 18-26), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dci.2019.02.019 - link to the publication
  2. Diverse Regulation of Vitamin D Receptor Gene Expression by 1,25-Dihydroxyvitamin D and ATRA in Murine and Human Blood Cells at Early Stages of Their Differentiation
    Authors:
    Janik S, Nowak U, Łaszkiewicz A, Satyr A, Majkowski M, Marchwicka A, Śnieżewski Ł, Berkowska K, Gabryś M, Cebrat M, Marcinkowska E
    Academic press:
    Int J Mol Sci (rok: 2017, tom: 18, strony: 1323), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms18061323 - link to the publication
  3. Investigating the Role of Methylation in Silencing of VDR Gene Expression in Normal Cells during Hematopoiesis and in Their Leukemic Counterparts
    Authors:
    Urszula Nowak, Sylwia Janik, Aleksandra Marchwicka, Agnieszka Łaszkiewicz, Agnieszka Jakuszak, Małgorzata Cebrat, Ewa Marcinkowska
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1991), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9091991 - link to the publication
  4. Regulation of vitamin D receptor expression by retinoic acid receptor alpha in acute myeloid leukemia cells.
    Authors:
    Marchwicka A, Cebrat M, Łaszkiewicz A, Śnieżewski Ł, Brown G, Marcinkowska E.
    Academic press:
    J Steroid Biochem Mol Biol (rok: 2016, tom: 159, strony: 121-130), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2016.03.013 - link to the publication
  5. The Vitamin D System in Humans and Mice: Similar but Not the Same
    Authors:
    Ewa Marcinkowska
    Academic press:
    Reports (rok: 2020, tom: 3, strony: 1), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/reports3010001 - link to the publication
  1. Experimental Premises for Differentiation Therapy of Acute Myeloid Leukaemia
    Authors:
    Marcinkowska E, Brown G.
    Book:
    Acute Myeloid Leukaemia (AML) Symptoms, Diagnosis and Treatment (rok: 2018, tom: 1, strony: 79-112), Wydawca: Nova Science Publishers
    Status:
    Published

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