Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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beta-Lactam analogues of antiviral oxetanocins

2015/17/B/ST5/00076

Keywords:

Kinugasa reaction phosphonylated nitrones beta-lactams phosphonates antiviral activity anticancer activity

Descriptors:

  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny, Katedra Chemii Bioorganicznej i Biokoordynacyjnej, Zakład Chemii Bioorganicznej

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dorota Piotrowska 

Number of co-investigators in the project: 4

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 324 000 PLN

Project start date (Y-m-d): 2016-01-19

Project end date (Y-m-d): 2020-01-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. reaktor ciśnieniowy do reakcji w małej skali umożliwiający pełną kontrolę wszystkich parametrów (60 000 PLN)
  2. termostat.

Information in the final report

  • Publication in academic press/journals (4)
  • Book publications / chapters in book publications (2)
  1. Design, Synthesis and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides
    Authors:
    Iwona E. Głowacka, Graciela Andrei, Dominique Schols, Robert Snoeck, Katarzyna Gawron
    Academic press:
    Archiv der Pharmazie. Chemistry in Life Sciences (rok: 2017, tom: 350, strony: 1-17 (e1700166)), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ardp.201700166 - link to the publication
  2. Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections
    Authors:
    Iwona E. Głowacka, Magdalena Grabkowska-Drużyc, Graciela Andrei, Dominique Schols, Robert Snoeck, Karolina Witek, Sabina Podlewska, Jadwiga Handzlik, Dorota G. Piotrowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 8032), Wydawca: Multidisciplinary Digital Publishing Institute (MPDI)
    Status:
    Published
    DOI:
    10.3390/ijms22158032 - link to the publication
  3. Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones
    Authors:
    Dorota G. Piotrowska, Laura Mediavilla, Leticia Cuarental, Iwona E. Głowacka, Jose Marco-Contelles, Dimitra Hadjipavlou-Litina, Francisco Lopez-Munoz and Maria Jesus Oset-Gasque
    Academic press:
    ACS Omega (rok: 2019, tom: 4, strony: 8581-8587), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.9b00189 - link to the publication
  4. β-LACTAM ANALOGUES OF OXETANOCINS – SYNTHESIS AND BIOLOGICAL ACTIVITY
    Authors:
    Iwona E. Głowacka, Magdalena Grabkowska-Drużyc, Liwia Lebelt, Graciela Andrei, Dominique Schols, Robert Snoeck, Dorota G. Piotrowska
    Academic press:
    Acta Poloniae Pharmaceutica. Drug Research (rok: 2022, tom: -, strony: -), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Accepted for publication
  1. -
    Authors:
    Magdalena Łysakowska, Iwona Głowacka, Dorota Piotrowska
    Book:
    POCHODNE CHINAZOLINO-2,4-DIONU – SYNTEZA I AKTYWNOŚĆ BIOLOGICZNA (rok: 2021, tom: 1, strony: 16803), Wydawca: Wydawnictwo Uniwersytetu Medycznego w Łodzi
    Status:
    Published
  2. -
    Authors:
    Iwona Rozpara, Iwona E. Głowacka, Dorota G. Piotrowska
    Book:
    SYNTEZA FOSFORYLOWANYCH NITRONÓW ORAZ ICH ZASTOSOWANIA (rok: 2021, tom: 10, strony: 16438), Wydawca: Wydawnictwo Uniwersytetu Medycznego w Łodzi
    Status:
    Published