Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Dipeptidyl peptidase 8 and 9 (DPP8 and 9) in the regulation of macrophage functions - proteomic approach to search for the novel strategies of pharmacotherapy of atherosclerosis.

2015/17/D/NZ2/01972

Keywords:

dipeptidyl peptidase 8/9 macrophages atherosclerosis secretome proteomics

Descriptors:

  • NZ2_3: Proteomics
  • NZ2_9: Systems biology
  • NZ4_4: Pathophysiology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maciej Suski 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 386 800 PLN

Project start date (Y-m-d): 2016-02-19

Project end date (Y-m-d): 2020-02-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kriostat (88 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages – quantitative proteomics of the proteome and secretome
    Authors:
    Maciej Suski, Anna Wiśniewska, Katarzyna Kuś, Anna Kiepura, Aneta Stachowicz, Kamila Stachyra, Klaudia Czepiel, Józef Madej, Rafał Olszanecki
    Academic press:
    Molecular Immunology (rok: 2020, tom: 127, strony: 193-202), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molimm.2020.09.005 - link to the publication
  2. Anti-atherosclerotic action of GW9508 – Free fatty acid receptors activator – In apoE-knockout mice
    Authors:
    Maciej Suski, Anna Kiepura, Anna Wiśniewska, Katarzyna Kuś, Anna Skałkowska, Kamila Stachyra, Aneta Stachowicz, Mariusz Gajda, Ryszard Korbut, Rafał Olszanecki
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 71(4), strony: 551-555), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1016/j.pharep.2019.02.014 - link to the publication

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