Projects funded by the NCN

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Targeting histone deacetylases as an approach to treat neonatal asphyxia.

2015/17/N/NZ7/00969

Keywords:

hypoxia-ischemia histone deacetylase inhibitors neurogenesis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Jaworska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 960 PLN

Project start date (Y-m-d): 2016-01-21

Project end date (Y-m-d): 2018-01-20

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Insights Into the Neuroinflammatory Responses After Neonatal Hypoxia-Ischemia
    Authors:
    Ziemka-Nalecz M, Jaworska J, Zalewska T
    Academic press:
    Journal of Neuropathology & Experimental Neurology (rok: 2017, tom: 76, strony: 644–654), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/jnen/nlx046 - link to the publication
  2. The potential neuroprotective role of a histone deacetylase inhibitor, Sodium Butyrate, after neonatal hypoxia-ischemia
    Authors:
    Joanna Jaworska, Malgorzata Ziemka-Nalecz, Joanna Sypecka, Teresa Zalewska
    Academic press:
    Journal of Neuroinflammation (rok: 2017, tom: 14, strony: brak), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12974-017-0807-8 - link to the publication
  3. Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia–Ischemia: Potential Mechanism of Action
    Authors:
    Joanna Jaworska, Teresa Zalewska, Joanna Sypecka, Malgorzata Ziemka-Nalecz
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: brak, strony: brak), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s12035-019-1518-1 - link to the publication
  1. A histone deacetylase inhibitor, Sodium Butyrate, prevents an inflammatory response associated with neonatal hypoxia-ischemia
    Authors:
    Jaworska J., Ziemka-Nalecz M., Zalewska T.
    Conference:
    Joint Conference: The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" and The 4th International Conference Stem cells: therapeutic outlook for central nervous system disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 17-18.11
    Status:
    Published
  2. Beneficial role of MMPs in neurogenesis after Sodium Butyrate treatment in a model of neonatal hypoxia-ischemia
    Authors:
    Ziemka-Nalecz M., Gajos M., Jaworska J., Sypecka J., Zalewska T.
    Conference:
    Joint Conference: The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders" and The 4th International Conference Stem cells: therapeutic outlook for central nervous system disorders" (rok: 2016, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 17-18.11
    Status:
    Published

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