Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Synthesis of Solanum alkaloids and their analogs from steroidal sapogenins

2015/17/B/ST5/02892

Keywords:

steroids alkaloids sapogenins spirosolanes spirostanes.

Descriptors:

  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet w Białymstoku, Wydział Chemii

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Morzycki 

Number of co-investigators in the project: 7

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 945 000 PLN

Project start date (Y-m-d): 2016-02-11

Project end date (Y-m-d): 2020-02-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wyparka rotacyjna; np. Hei-VAP Value; G1 chłodnica kątowa, szkło standardowe (15 000 PLN)
  2. Zestaw do gradientowej chromatografii flash (np. system Sepacore Easy Synthesis) (60 000 PLN)
  3. Laboratoryjna waga analityczna (15 000 PLN)
  4. Zestaw do prowadzenia reakcji w podwyższonych temperaturach. W skład zestawu wchodzą: mieszadło magnetyczne z grzaniem i czujnikem temperatury (np.., MR Hei-Tec, MR Hei-End), Blok Heat-On grzejny 500 mL, Nakładka Multi-Well Holder do wkładek Heat- On, Wkładki Heat- On do kolb o pojemności 25, 50 i 100 ml oraz chłodnica powietrzna Findenser. (2 szt.) (24 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  1. Access to 27-nortomatidine and 27-norsoladulcidine derivatives
    Authors:
    D. Czajkowska-Szczykowska, A. Corona Díaz, G. Aleksiejczuk, J. W. Morzycki
    Academic press:
    The Journal of Organic Chemistry (rok: 2019, tom: 84, strony: 4104-4111), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.joc.9b00103 - link to the publication
  2. Study on the reaction of diosgenin acetate with trimethylsilylazide catalyzed by Lewis acids
    Authors:
    A. Wojtkielewicz, U. Kiełczewska, B. Banel, J. W. Morzycki
    Academic press:
    Steroids (rok: 2019, tom: 147, strony: 58-61), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.007 - link to the publication
  3. Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines
    Authors:
    R. Jorda, E. Řezníčková, U. Kiełczewska, J. Maj, J. W. Morzycki, L. Siergiejczyk, V. Bazgier, K. Berka, L. Rárová, A. Wojtkielewicz
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 179, strony: 483-492), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jorganchem.2019.06.018 - link to the publication
  4. The synthesis and cholinesterase inhibitory activities of solasodine analogues with seven-membered F ring
    Authors:
    U. Kiełczewska, R. Jorda, G. Gonzalez, J. W. Morzycki, H. Ajani, K. Svrčkova, Š. Štěpankova, A. Wojtkielewicz
    Academic press:
    Journal of Steroid Biochemistry and Molecular Biology (rok: 2021, tom: 205, strony: article 105776), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2020.105776 - link to the publication
  5. The synthesis and antifungal activity of (20S)-3beta-acetoxy-5alfa-pregnane-20,16beta-carbolactone against fluconazole – Resistant Candida cells
    Authors:
    I. Jastrzebska, K. Niemirowicz, W. I. Brzozowska, R. Bucki
    Academic press:
    Steroids (rok: 2017, tom: 118, strony: 55-60), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.steroids.2016.12.009 - link to the publication
  6. Two-step synthesis of solasodine pivalate from diosgenin pivalate
    Authors:
    A. Wojtkielewicz, U. Kiełczewska, J. W. Morzycki
    Academic press:
    Molecules (rok: 2019, tom: 24, strony: 1132 (1-8)), Wydawca: Molecular Diversity Preservation International
    Status:
    Published
    DOI:
    10.3390/molecules24061132 - link to the publication
  7. A convenient synthesis of (16S,20S)‐3β‐hydroxy‐5α‐pregnane‐20,16‐carbolactam and its N‐alkyl derivatives
    Authors:
    A. Wojtkielewicz, D. Pawelski, P. Bazydło, A. Baj, S. Witkowski, J. W. Morzycki
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: article 2377), Wydawca: Molecular Diversity Preservation International
    Status:
    Published
    DOI:
    10.3390/molecules25102377 - link to the publication
  8. Some observations on solasodine reactivity
    Authors:
    I. Jastrzebska, J. W. Morzycki
    Academic press:
    Steroids (rok: 2017, tom: 127, strony: 13-17), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.steroids.2017.08.015 - link to the publication
  9. Dehydroepiandrosterone derived imidazolium salts and their antimicrobial efficiacy
    Authors:
    A. Hryniewicka, K. Niemirowicz-Laskowska, P. Wielgat, H. Car, T. Hauschild, J. W. Morzycki
    Academic press:
    Bioorganic Chemistry (), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.bioorg.2020.104550 - link to the publication
  10. Revision of the structure of N,O-diacetylsolasodine. Unusual epimerization at the spiro carbon atom during acetylation of solasodine
    Authors:
    D. Czajkowska-Szczykowska, I. Jastrzebska, J. E. Rode, J. W. Morzycki
    Academic press:
    Journal of Natural Products (rok: 2019, tom: 82, strony: 59-65), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.jnatprod.8b00573 - link to the publication
  11. Synthesis of Solanum alkaloid demissidine stereoisomers and analogues
    Authors:
    J. A. Rivas-Loaiza, A. Baj, Y. López, S. Witkowski, A. Wojtkielewicz, J. W. Morzycki
    Academic press:
    The Journal of Organic Chemistry (rok: 2021, tom: 86, strony: 1575-1582), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.joc.0c02410 - link to the publication
  12. The synthesis of solasodine F-homo-analogues
    Authors:
    U. Kiełczewska, J. W. Morzycki, L. Rárová, A. Wojtkielewicz
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2019, tom: 17, strony: 9050-9058), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9OB01888C - link to the publication
  13. A study on the reaction of 16-dehydropregnenolone acetate with 2-aminobenzimidazole
    Authors:
    A. Wojtkielewicz, P. Uścinowicz, L. Siergiejczyk, U. Kiełczewska, A. Ratkiewicz, J. W. Morzycki
    Academic press:
    Steroids (rok: 2017, tom: 117, strony: 71-76), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.steroids.2016.09.003 - link to the publication
  14. Synthesis and antimicrobial properties of steroid-based imidazolium salts
    Authors:
    A. Hryniewicka, M. Malinowska, T. Hauschild, K. Pieczul, J. W. Morzycki
    Academic press:
    Journal of Steroid Biochemistry and Molecular Biology (rok: 2019, tom: 189, strony: 65-72), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2019.02.006 - link to the publication

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