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New insights into the role of mixed biofilms with the participiation of Candida albicans in the development of periodontal disease.

2015/17/B/NZ6/02078

Keywords

Descriptors

  • NZ6_7: Mykologia
  • NZ6_4: Bakteriologia

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Maria Rąpała-Kozik

Number of co-investigators in the project: 6

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
396 000 PLN
Project start date
2016-02-12
Project end date
2018-09-11
Project duration
31 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Uniwersalna, szybkoobrotowa wirówka laboratoryjna z chłodzeniem, z wymiennymi rotorami,. Cost: 35 000 PLN
  2. szafowa zamrażarka niskotemperaturowa (-80C). Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Adhesive protein-mediated cross-talk between Candida albicans and Porphyromonas gingivalis in dual species biofilm protects the anaerobic bacterium in unfavorable oxic environment

    Authors:
    Dominika Bartnicka, Justyna Karkowska-Kuleta, Marcin Zawrotniak, Dorota Satała, Kinga Michalik, Gabriela Zielinska, Oliwia Bochenska, Andrzej Kozik, Izabela Ciaston, Joanna Koziel, Lindsay C. Dutton, Angela H. Nobbs, Barbara Potempa, Zbigniew Baster, Zenon Rajfur, Jan Potempa, Maria Rapala-Kozik
    Academic press:
    Scientific Reports (year: 2019, volume: 9, pages: 4376), Publisher: Nature Research Journals
    Status:
    Published
    DOI:
    10.1038/s41598-019-40771-8 – link to the publication

  2. Peptidylarginine deiminase of Porphyromonas gingivalis modulates the interactions between mixed fungal-bacterial biofilm and host proteins

    Authors:
    Justyna Karkowska-Kuleta, Magdalena Surowiec , Mariusz Gogól , Joanna Kozieł , Barbara Potempa, Jan Potempa, Andrzej Kozik and Maria Rąpała-Kozik *
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21(7), pages: 2495), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072495 – link to the publication

  3. The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans

    Authors:
    Karkowska-Kuleta Justyna, Dominika Bartnicka, Marcin Zawrotniak, Gabriela Zielinska, Anna Kierońska, Oliwia Bochenska, Izabela Ciaston Joanna Koziel, Jan Potempa, Zbigniew Baster, Zenon Rajfur, Maria Rapala-Kozik,*
    Academic press:
    Pathogens and Disease (year: 2018, volume: 76, pages: fty033), Publisher: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/femspd/fty033 – link to the publication

  4. Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue

    Authors:
    Dominika Bartnicka, Miriam Gonzalez-Gonzales, Joanna Sykut, Joanna Koziel, Izabela Ciaston2, Karina Adamowicz, Grazyna Bras, Marcin Zawrotniak1, Justyna Karkowska-Kuleta, Dorota Satala, Andrzej Kozik, Edyta Zyla, Katarzyna Gawron, Katarzyna Lazarz-Bartyzel, Maria Chomyszyn-Gajewska and Maria Rapala-Kozik*
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21(6), pages: 1984), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21061984. – link to the publication

Articles in post-conference publications (5)

  1. Human Gingival Fibroblasts from Patients Infected with Periodontal Pathogens are Less Sensitive to Candida albicans Infection

    Authors:
    Rapala-Kozik M., Ostrowska D., Sykut J., Bochenska O., Karkowska-Kuleta J., Seweryn K., Kozik A
    Conference:
    Microbe 2016 (year: 2016, pages: poster no. 546), Publisher: ASM
    Date:
    conference 16-20 czerwca
    Status:
    Published

  2. Porphyromonas gingivalis uses citrullination in mixed species biofilms

    Authors:
    J. Karkowska-Kuleta, D. Ostrowska, G. Zielińska, A. Kierońska, I. Glowczyk, M. Zawrotniak, O. Bocheńska, J. Koziel, M. Rapala-Kozik
    Conference:
    Eurobiofilms 2017 (V European Congress on Microbial Biofilms) (year: 2017, pages: Poster S-63, p. 70), Publisher: European Society of Clinical Microbiology and Infectious Diseases
    Date:
    conference 19-22.09.
    Status:
    Published

  3. Candida albicans protects anaerobial bacteria in mixed species biofilm

    Authors:
    Ostrowska D., Zielińska G., Karkowska-Kuleta J., Kierońska A., Glowczyk I., Proba A., Zawrotniak M., Koziel J., Rapala-Kozik M.
    Conference:
    Eurobiofilms 2017 (V European Congress on Microbial Biofilms) (year: 2017, pages: Poster 016, p.90), Publisher: European Society of Clinical Microbiology and Infectious Diseases
    Date:
    conference 19-22.09.
    Status:
    Published

  4. Biofilm formation between fungal oportunist- Candida albicans ang gingiva pathogen -Phorphyromonas gingivalis

    Authors:
    D. Ostrowska, Zielińska G., Karkowska-Kuleta, A. Kierońska, I. Główczyk, J. Kozieł, M. Rąpała-Kozik
    Conference:
    XLIV Winter School Faculty of Biochemistry, Biophysics and Biotechnology (year: 2017, pages: A21/100), Publisher: Jagiellonian University in Kraków
    Date:
    conference 14-18 luty
    Status:
    Published

  5. Cell surface enolase of Candida species is involved in the interactions with human host and the formation of polymicrobial biofilms

    Authors:
    M. Rapala-Kozik, J. Karkowska-Kuleta, D. Satala, M. Gogol, D. Bartnicka, M. Zawrotniak, A. Kozik
    Conference:
    20th Congress of the International Society for Human and Animal Mycology (year: 2018, pages: Poster 401, S141), Publisher: ISHAM
    Date:
    conference 30.06.-4.07.
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Interactions of Candida albicans Cells with Aerobic and Anaerobic Bacteria during Formation of Mixed Biofilms in the Oral Cavity

    Authors:
    M. Rapala-Kozik, M. Zawrotniak, M. Gogol, D. Bartnicka, D. Satala, M. Smolarz, J. Karkowska-Kuleta, A. Kozik
    Book:
    Candida albicans (year: 2019, volume: 43556, pages: 119-142), Publisher: IntechOpen ISBN 978-953-51-6399-2
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski