Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Bioanalitycal and pharmacological studies on the compensatory mechanism dependent on MNA/COX-2/PGI2 pathway in NO-deficient mice.

2015/17/N/NZ7/01044

Keywords:

eicosanoids hypertension MNA prostacyclin

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agnieszka Kij 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 992 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2018-09-15

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny (4 000 PLN)
  2. Pipeta automatyczna o zmiennej objętości (1 704 PLN)
  3. Uchwyt do homogenizatora Precellys Evolution.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (7)
  1. Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method
    Authors:
    Kij Agnieszka, Mateuszuk Lukasz, Sitek Barbara, Przyborowski Kamil, Zakrzewska Agnieszka, Wandzel Krystyna, Walczak Maria, Chlopicki Stefan
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2016, tom: 129, strony: 148-154), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2016.06.050 - link to the publication
  2. Differential effects of NO deficiency on primary tumour growth, pulmonary metastasis and PGI2/TXA2 balance in orthotopic and intravenous murine models of 4T1 breast cancer
    Authors:
    Agnieszka Kij, Kamil Kus, Marta Smeda, Agnieszka Zakrzewska, Bartosz Proniewski, Karolina Matyjaszczyk, Agnieszka Jasztal, Marta Stojak, Maria Walczak, Stefan Chlopicki
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 69, strony: 911-919), Wydawca: The Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.6.05 - link to the publication
  1. Early alternations in the balance of eicosanoids profile in murine model of breast cancer with pulmonary metastasis based on in vivo and ex vivo profiling
    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Magdalena Sternak, Marta Stojak, Maria Walczak, Stefan Chlopicki
    Conference:
    The 17th International Winter Eicosanoid Conference (rok: 2018, ), Wydawca: Eicosanoid Research Association, Inc.
    Data:
    konferencja March 11-13, 2018
    Status:
    Published
  2. Targeted Profiling of Eicosanoids in the Endothelial Dysfunction Mice Models Applying UPLC/MS/MS Technique
    Authors:
    Kij Agnieszka, Kus Kamil, Zakrzewska Agnieszka, Proniewski Bartosz, Wietrzyk Joanna, Walczak Maria, Chlopicki Stefan
    Conference:
    1st International Conference on Pharmaceutical and Medical Sciences (rok: 2016, ), Wydawca: Faculty of Pharmacy Jagiellonian University Medical College & ZOZ Ośrodek UMEA SHINODA-KURACEJO
    Data:
    konferencja 22-24 lipiec 2016
    Status:
    Published
  3. The targeted profiling of selected eicosanoids using UPLC/MS/MS technique; Application to the endothelial dysfunction mice models
    Authors:
    Kij Agnieszka, Walczak Maria, Chlopicki Stefan
    Conference:
    34th Informal Meeting on Mass Spectrometry (rok: 2016, ), Wydawca: Divisione di Spettrometria di Massa-Societa Chimica Italiana and Italian Mass Spectrometry Society
    Data:
    konferencja 15-18 maj 2016
    Status:
    Published
  4. Changes in arachidonic acid metabolism during the development of metastatic breast cancer in mice
    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Joanna Wietrzyk, Maria Walczak, Stefan Chlopicki
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences. Towards novel concepts in pharmaceutical sciences (rok: 2017, ), Wydawca: Kraków, Wydawnictwo Fall, 2017
    Data:
    konferencja 26-27.05.2017
    Status:
    Published
  5. Targeted profiling of eicosanoids in the progression of metastatic breast cancer in mice
    Authors:
    Kij Agnieszka, Kus Kamil, Zakrzewska Agnieszka, Proniewski Bartosz, Wietrzyk Joanna, Walczak Maria, Chlopicki Stefan
    Conference:
    The 6th European Workshop on Lipid Mediators (rok: 2016, ), Wydawca: European Society for Lipid Mediators (ESLM)
    Data:
    konferencja 27-30 wrzesień 2016
    Status:
    Published
  6. Metoda jednoczesnej analizy ilościowej wybranych eikozanoidow w próbkach biologicznych z zastosowaniem techniki UPLC/MS/MS
    Authors:
    Kij Agnieszka, Walczak Maria, Chlopicki Stefan
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego – Collegium Medicum (rok: 2016, ), Wydawca: Nowa Strona-Katarzyna Migdał (Numer czasopisma finansowany ze środków Towarzystwa Doktorantów UJ oraz Cellegium Medicum)
    Data:
    konferencja 23 kwiecień 2016
    Status:
    Published
  7. Ex vivo profiling of arachidonic acid-derived eicosanoids in murine orthotopic model of metastatic breast cancer (4T1)
    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Karolina Matyjaszczyk, Marta Smeda, Maria Walczak, Stefan Chlopicki
    Conference:
    25th Kraków Conference on Endothelium (rok: 2017, ), Wydawca: Jagiellonian Medical Research Centre (JMRC)
    Data:
    konferencja 20-21.10.2017
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy