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Bioanalitycal and pharmacological studies on the compensatory mechanism dependent on MNA/COX-2/PGI2 pathway in NO-deficient mice.

2015/17/N/NZ7/01044

Keywords

Descriptors

  • NZ7_14: Farmacja, farmakoterapia, farmakologia
  • NZ7_16: Inne zagadnienia pokrewne

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Agnieszka Róża Kij

Number of co-investigators in the project: 3

Call

PRELUDIUM 9 – announced on 2015-03-16

Amount awarded
99 992 PLN
Project start date
2016-03-16
Project end date
2018-09-15
Project duration
30 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny. Cost: 4 000 PLN
  2. Pipeta automatyczna o zmiennej objętości. Cost: 1 704 PLN
  3. Uchwyt do homogenizatora Precellys Evolution.

Information in the final report

Publication in academic press/journals (2)

  1. Differential effects of NO deficiency on primary tumour growth, pulmonary metastasis and PGI2/TXA2 balance in orthotopic and intravenous murine models of 4T1 breast cancer

    Authors:
    Agnieszka Kij, Kamil Kus, Marta Smeda, Agnieszka Zakrzewska, Bartosz Proniewski, Karolina Matyjaszczyk, Agnieszka Jasztal, Marta Stojak, Maria Walczak, Stefan Chlopicki
    Academic press:
    Journal of Physiology and Pharmacology (year: 2018, volume: 69, pages: 911-919), Publisher: The Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.6.05 – link to the publication

  2. Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method

    Authors:
    Kij Agnieszka, Mateuszuk Lukasz, Sitek Barbara, Przyborowski Kamil, Zakrzewska Agnieszka, Wandzel Krystyna, Walczak Maria, Chlopicki Stefan
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (year: 2016, volume: 129, pages: 148-154), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2016.06.050 – link to the publication

Articles in post-conference publications (7)

  1. Ex vivo profiling of arachidonic acid-derived eicosanoids in murine orthotopic model of metastatic breast cancer (4T1)

    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Karolina Matyjaszczyk, Marta Smeda, Maria Walczak, Stefan Chlopicki
    Conference:
    25th Kraków Conference on Endothelium (year: 2017, pages: 64), Publisher: Jagiellonian Medical Research Centre (JMRC)
    Date:
    conference 20-21.10.2017
    Status:
    Published

  2. Changes in arachidonic acid metabolism during the development of metastatic breast cancer in mice

    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Joanna Wietrzyk, Maria Walczak, Stefan Chlopicki
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences. Towards novel concepts in pharmaceutical sciences (year: 2017, pages: 189-190), Publisher: Kraków, Wydawnictwo Fall, 2017
    Date:
    conference 26-27.05.2017
    Status:
    Published

  3. Early alternations in the balance of eicosanoids profile in murine model of breast cancer with pulmonary metastasis based on in vivo and ex vivo profiling

    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Magdalena Sternak, Marta Stojak, Maria Walczak, Stefan Chlopicki
    Conference:
    The 17th International Winter Eicosanoid Conference (year: 2018, pages: 18), Publisher: Eicosanoid Research Association, Inc.
    Date:
    conference March 11-13, 2018
    Status:
    Published

  4. Metoda jednoczesnej analizy ilościowej wybranych eikozanoidow w próbkach biologicznych z zastosowaniem techniki UPLC/MS/MS

    Authors:
    Kij Agnieszka, Walczak Maria, Chlopicki Stefan
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego – Collegium Medicum (year: 2016, pages: 55), Publisher: Nowa Strona-Katarzyna Migdał (Numer czasopisma finansowany ze środków Towarzystwa Doktorantów UJ oraz Cellegium Medicum)
    Date:
    conference 23 kwiecień 2016
    Status:
    Published

  5. Targeted profiling of eicosanoids in the progression of metastatic breast cancer in mice

    Authors:
    Kij Agnieszka, Kus Kamil, Zakrzewska Agnieszka, Proniewski Bartosz, Wietrzyk Joanna, Walczak Maria, Chlopicki Stefan
    Conference:
    The 6th European Workshop on Lipid Mediators (year: 2016, pages: 110), Publisher: European Society for Lipid Mediators (ESLM)
    Date:
    conference 27-30 wrzesień 2016
    Status:
    Published

  6. Targeted Profiling of Eicosanoids in the Endothelial Dysfunction Mice Models Applying UPLC/MS/MS Technique

    Authors:
    Kij Agnieszka, Kus Kamil, Zakrzewska Agnieszka, Proniewski Bartosz, Wietrzyk Joanna, Walczak Maria, Chlopicki Stefan
    Conference:
    1st International Conference on Pharmaceutical and Medical Sciences (year: 2016, pages: 50-51), Publisher: Faculty of Pharmacy Jagiellonian University Medical College & ZOZ Ośrodek UMEA SHINODA-KURACEJO
    Date:
    conference 22-24 lipiec 2016
    Status:
    Published

  7. The targeted profiling of selected eicosanoids using UPLC/MS/MS technique; Application to the endothelial dysfunction mice models

    Authors:
    Kij Agnieszka, Walczak Maria, Chlopicki Stefan
    Conference:
    34th Informal Meeting on Mass Spectrometry (year: 2016, pages: 87-88), Publisher: Divisione di Spettrometria di Massa-Societa Chimica Italiana and Italian Mass Spectrometry Society
    Date:
    conference 15-18 maj 2016
    Status:
    Published

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