Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Bioanalitycal and pharmacological studies on the compensatory mechanism dependent on MNA/COX-2/PGI2 pathway in NO-deficient mice.

2015/17/N/NZ7/01044

Keywords:

eicosanoids hypertension MNA prostacyclin

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agnieszka Kij 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 992 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2018-09-15

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny (4 000 PLN)
  2. Pipeta automatyczna o zmiennej objętości (1 704 PLN)
  3. Uchwyt do homogenizatora Precellys Evolution.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (7)
  1. Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method
    Authors:
    Kij Agnieszka, Mateuszuk Lukasz, Sitek Barbara, Przyborowski Kamil, Zakrzewska Agnieszka, Wandzel Krystyna, Walczak Maria, Chlopicki Stefan
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2016, tom: 129, strony: 148-154), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2016.06.050 - link to the publication
  2. Differential effects of NO deficiency on primary tumour growth, pulmonary metastasis and PGI2/TXA2 balance in orthotopic and intravenous murine models of 4T1 breast cancer
    Authors:
    Agnieszka Kij, Kamil Kus, Marta Smeda, Agnieszka Zakrzewska, Bartosz Proniewski, Karolina Matyjaszczyk, Agnieszka Jasztal, Marta Stojak, Maria Walczak, Stefan Chlopicki
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 69, strony: 911-919), Wydawca: The Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.6.05 - link to the publication
  1. Changes in arachidonic acid metabolism during the development of metastatic breast cancer in mice
    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Joanna Wietrzyk, Maria Walczak, Stefan Chlopicki
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences. Towards novel concepts in pharmaceutical sciences (rok: 2017, ), Wydawca: Kraków, Wydawnictwo Fall, 2017
    Data:
    konferencja 26-27.05.2017
    Status:
    Published
  2. Targeted profiling of eicosanoids in the progression of metastatic breast cancer in mice
    Authors:
    Kij Agnieszka, Kus Kamil, Zakrzewska Agnieszka, Proniewski Bartosz, Wietrzyk Joanna, Walczak Maria, Chlopicki Stefan
    Conference:
    The 6th European Workshop on Lipid Mediators (rok: 2016, ), Wydawca: European Society for Lipid Mediators (ESLM)
    Data:
    konferencja 27-30 wrzesień 2016
    Status:
    Published
  3. Early alternations in the balance of eicosanoids profile in murine model of breast cancer with pulmonary metastasis based on in vivo and ex vivo profiling
    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Magdalena Sternak, Marta Stojak, Maria Walczak, Stefan Chlopicki
    Conference:
    The 17th International Winter Eicosanoid Conference (rok: 2018, ), Wydawca: Eicosanoid Research Association, Inc.
    Data:
    konferencja March 11-13, 2018
    Status:
    Published
  4. Metoda jednoczesnej analizy ilościowej wybranych eikozanoidow w próbkach biologicznych z zastosowaniem techniki UPLC/MS/MS
    Authors:
    Kij Agnieszka, Walczak Maria, Chlopicki Stefan
    Conference:
    VI Konferencja Doktorantów Uniwersytetu Jagiellońskiego – Collegium Medicum (rok: 2016, ), Wydawca: Nowa Strona-Katarzyna Migdał (Numer czasopisma finansowany ze środków Towarzystwa Doktorantów UJ oraz Cellegium Medicum)
    Data:
    konferencja 23 kwiecień 2016
    Status:
    Published
  5. The targeted profiling of selected eicosanoids using UPLC/MS/MS technique; Application to the endothelial dysfunction mice models
    Authors:
    Kij Agnieszka, Walczak Maria, Chlopicki Stefan
    Conference:
    34th Informal Meeting on Mass Spectrometry (rok: 2016, ), Wydawca: Divisione di Spettrometria di Massa-Societa Chimica Italiana and Italian Mass Spectrometry Society
    Data:
    konferencja 15-18 maj 2016
    Status:
    Published
  6. Ex vivo profiling of arachidonic acid-derived eicosanoids in murine orthotopic model of metastatic breast cancer (4T1)
    Authors:
    Agnieszka Kij, Kamil Kus, Agnieszka Zakrzewska, Karolina Matyjaszczyk, Marta Smeda, Maria Walczak, Stefan Chlopicki
    Conference:
    25th Kraków Conference on Endothelium (rok: 2017, ), Wydawca: Jagiellonian Medical Research Centre (JMRC)
    Data:
    konferencja 20-21.10.2017
    Status:
    Published
  7. Targeted Profiling of Eicosanoids in the Endothelial Dysfunction Mice Models Applying UPLC/MS/MS Technique
    Authors:
    Kij Agnieszka, Kus Kamil, Zakrzewska Agnieszka, Proniewski Bartosz, Wietrzyk Joanna, Walczak Maria, Chlopicki Stefan
    Conference:
    1st International Conference on Pharmaceutical and Medical Sciences (rok: 2016, ), Wydawca: Faculty of Pharmacy Jagiellonian University Medical College & ZOZ Ośrodek UMEA SHINODA-KURACEJO
    Data:
    konferencja 22-24 lipiec 2016
    Status:
    Published

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