Projects funded by the NCN

Information on the principal investigator and host institution

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Mesenchymal stromal cells (MSC) as carriers of IL-12 cDNA in treatment of mice with melanoma B16-F10 and metastases

2015/17/N/NZ4/02738

Keywords:

mesenchymal stromal cells anticancer cell therapy IL-12 murine melanoma B16-F10

Descriptors:

  • NZ4_12: Other related subjects
  • NZ5_7: Human disease treatment

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Natalia Kułach 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 400 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2019-09-15

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Combination of anti-vascular agent - DMXAA and HIF-1α inhibitor - digoxin inhibits the growth of melanoma tumors
    Authors:
    Ryszard Smolarczyk, Tomasz Cichoń, Ewelina Pilny, Magdalena Jarosz-Biej, Aleksandra Poczkaj, Natalia Kułach, Stanisław Szala
    Academic press:
    Scientific Reports volume 8 (rok: 2018, tom: 8, strony: 7355), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-25688-y - link to the publication
  2. Mesenchymal stromal cells as carriers of IL-12 reduce primary and metastatic tumors of murine melanoma
    Authors:
    Natalia Kułach, Ewelina Pilny, Tomasz Cichoń, Justyna Czapla, Magdalena Jarosz-Biej, Marek Rusin, Alina Drzyzga, Sybilla Matuszczak, Stanisław Szala, Ryszard Smolarczyk
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: -), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-021-97435-9 - link to the publication
  1. Combination of antivascular agent-DMXAA and inhibitor of HIF-1α -digoxin inhibited melanoma tumor growth.
    Authors:
    Ryszard Smolarczyk, Tomasz Cichoń, Ewelina Pilny, Magdalena Jarosz-Biej, Aleksandra Poczkaj, Natalia Kułach, Stanisław Szala.
    Conference:
    XXI Gliwice Scientific Meetings 2017 (rok: 2017, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 17-18.09
    Status:
    Published
  2. IL-12 Secreted by modified MSC significantly reduces the volume of primary tumors and the number of lung metastases of murine melanoma.
    Authors:
    Natalia Kułach, Magdalena Jarosz-Biej, Tomasz Cichoń, Ewelina Pilny, Marek Rusin, Alina Hadyk, Stanisław Szala, Ryszard Smolarczyk
    Conference:
    XXII Gliwice Scientific Meeting 2018 (rok: 2018, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 16-17.09
    Status:
    Published
  3. Mesenchymal Stromal Cells (MSC) as carriers of IL-12 cDNA in treatment of mice bearing melanowa B16-F10.
    Authors:
    Natalia Kułach, Tomasz Cichoń, Magdalena Jarosz-Biej, Marek Rusin, Ewelina Pilny, Stanisław Szala, Ryszard Smolarczyk
    Conference:
    XXI Gliwice Scientific Meetings (rok: 2017, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 17-18.09
    Status:
    Published
  4. The effectiveness of anti-vascular DMXAA combined with brachytherapy in anticancer therapy.
    Authors:
    Alina Hadyk, Tomasz Cichoń, Piotr Wojcieszek, Zbigniew Urbaś, Ewelina Pilny, Magdalena Jarosz-Biej, Stanisław Szala, Natalia Kułach, Ryszard Smolarczyk
    Conference:
    XXII Gliwice Scientific Meeting 2018 (rok: 2018, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 16-17.09
    Status:
    Published

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