Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of Zebrafish mTOR in neuronal development in vivo as a key regulator of neuronal circuit formation.

2015/17/D/NZ3/03735

Keywords:

mTOR signaling pathway neuronal differentiation neuronal migration neuronal circuits

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_13: Developmental biology in animals
  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Justyna Zmorzyńska 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 689 000 PLN

Project start date (Y-m-d): 2016-02-22

Project end date (Y-m-d): 2019-12-21

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie do analizy obrazów 3D (12 000 PLN)
  2. DYSK ZEWNĘTRZNY (307 PLN)
  3. System do hodowli i utrzymania ryb (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Molecular neurobiology of mTOR
    Authors:
    K. Switon, K. Kotulska, A. Janusz-Kaminska, J. Zmorzynska, J. Jaworski
    Academic press:
    Neuroscience (rok: 2017, tom: 341, strony: 112-153), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2016.11.017 - link to the publication
  2. TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex
    Authors:
    Magdalena Kedra, Katarzyna Banasiak, Katarzyna Kisielewska, Lidia Wolinska-Niziol, Jacek Jaworski, and Justyna Zmorzynska
    Academic press:
    Proceedings of the National Academy of Sciences of the United States of America (PNAS) (rok: 2020, tom: 117 (4), strony: 2170-2179), Wydawca: PNAS
    Status:
    Published
    DOI:
    10.1073/pnas.1910834117 - link to the publication
  3. Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2.
    Authors:
    Alicja Koscielny, Anna R. Malik, Ewa Liszewska, Justyna Zmorzynska, Aleksandra Tempes, Bartosz Tarkowski, Jacek Jaworski
    Academic press:
    Molecular Neurobiology (rok: 2018, tom: 55(2), strony: 1590-1606), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-017-0436-3 - link to the publication
  4. Okiem ryby - nowe spojrzenie na rozwój sieci neuronalnych i choroby neurorozwojowe.
    Authors:
    M. Kędra, J. Jaworski i J. Zmorzyńska.
    Academic press:
    Wszechświat Pismo Przyrodnicze (rok: 2016, tom: 117(nr 10-12), strony: 270-277), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Tuberous Sclerosis Complex: From Molecular Biology to Novel Therapeutic Approaches.
    Authors:
    K. Switon, K. Kotulska, A. Janusz-Kaminska, J. Zmorzynska, J. Jaworski.
    Academic press:
    IUBMB Life (rok: 2016, tom: 68(12), strony: 955-962), Wydawca: John Wiley and sons, Inc.
    Status:
    Published
    DOI:
    10.1002/iub.1579 - link to the publication

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