Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Comparative mRNA expression, protein abundance and regulatory mechanisms of drug metabolising eznymes and transporters in human liver and gastrointestinal tract

2015/17/B/NZ7/03066

Keywords:

drug metabolizing enzymes drug transporters expression liver gastrointestinal tract

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Droździk 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 841 584 PLN

Project start date (Y-m-d): 2016-02-03

Project end date (Y-m-d): 2019-09-02

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr (75 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Protein abundance of clinically relevant drug metabolizing enzymes in the human liver and intestine: A comparative analysis in paired tissue specimens
    Authors:
    Drozdzik M, Busch D, Lapczuk J, Müller J, Ostrowski M, Kurzawski M, Oswald S.
    Academic press:
    Clin. Pharmacol. Ther. (rok: 2018, tom: 104, strony: 515-524), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cpt.967 - link to the publication
  2. Expression and Regulation of Drug Transporters and Metabolizing Enzymes in the Human Gastrointestinal Tract
    Authors:
    Drozdzik M, Oswald S.
    Academic press:
    Curr Med Chem (rok: 2016, tom: 23, strony: 4468-4489), Wydawca: BenthamScience
    Status:
    Published
    DOI:
    10.2174/0929867323666161024154457 - link to the publication
  3. Protein Abundance of Clinically Relevant Drug Transporters in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens
    Authors:
    Drozdzik M, Busch D, Lapczuk J, Müller J, Ostrowski M, Kurzawski M, Oswald S
    Academic press:
    Clin Pharmacol Ther (rok: 2019, tom: 105, strony: 1204-1212), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cpt.1301 - link to the publication
  4. Clinically relevant multidrug transporters are regulated by microRNAs along the human intestine
    Authors:
    236.Bruckmueller H., Martin P., Kähler M., Haenisch S., Ostrowski M., Drozdzik M., Siegmund W., Cascorbi I, Oswald S
    Academic press:
    Mol. Pharm. (rok: 2017, tom: 14, strony: 2245-2253), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.7b00076 - link to the publication
  1. Protein abundance of clinically relevant drug metabolizing enzymes in the human liver and along the intestine: a comparative analysis in paired tissue specimens
    Authors:
    M. Drozdzik, D. Busch, J. Lapczuk, J. Mueller, M. Kurzawski, S. Oswald
    Conference:
    2018 Annual Meeting of ASCPT (rok: 2018, ), Wydawca: Wiley
    Data:
    konferencja 21-24.03
    Status:
    Published
  2. Protein abundance of clinically relevant drug transporters in paired human liver and intestinal tissue specimens
    Authors:
    M. Drozdzik, J. Lapczuk, D. Busch, M. Ostrowski, M. Kurzawski, S. Oswald
    Conference:
    Pharmacology (rok: 2018, ), Wydawca: British Pharmacological Society
    Data:
    konferencja 18-20.12
    Status:
    Published

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