Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Porphyromonas gingivalis protein and its homologs from other periodontopathogens - a novel group of bacterial virulence factors

2015/17/B/NZ6/01969

Keywords:

Porphyromonas gingivalis periodontal diseases HmuY protein virulence Toll-like receptors heme immune response macrophages

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_10: Microbiology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Olczak 

Number of co-investigators in the project: 8

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 898 000 PLN

Project start date (Y-m-d): 2016-02-16

Project end date (Y-m-d): 2019-02-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do rozdziału makrocząsteczek FPLC (160 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Prevotella intermedia produces two proteins homologous to Porphyromonas gingivalis HmuY but with different heme coordination mode
    Authors:
    Bielecki M., Antonyuk S., Strange R.W., Sieminska K., Smalley J.W., Mackiewicz P., Smiga M., Cowan M.,Capper M.J., Slezak P., Olczak M., Olczak T.
    Academic press:
    Biochemical Journal (rok: 2020, tom: 477, strony: 381-405), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20190607 - link to the publication
  2. Role of Porphyromonas gingivalis HmuY in immunopathogenesis of chronic periodontitis.
    Authors:
    Carvalho-Filho P.C., Gomes-Filho I.S., Meyer R., Olczak T., Xavier M.T., Trindade S.C.
    Academic press:
    Mediators of Inflammation (rok: 2016, tom: 2016:7465852, strony: 45300), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2016/7465852 - link to the publication
  3. Apoptosis transcriptional profile induced by Porphyromonas gingivalis HmuY
    Authors:
    Carvalho-Filho PC, de Moura-Costa LF, Pimentel ACM, Lopes M, Freitas SA, Miranda PM, Costa R, Figueiredo CA, Meyer R, Gomes-Filho IS, Olczak T, Xavier MT, Trindade SC
    Academic press:
    Mediators of Inflammation (rok: 2019, tom: 2019:6758159, strony: 45299), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2019/6758159 - link to the publication
  4. Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein.
    Authors:
    Gmiterek A., Kłopot A., Wójtowicz H., Trindade S.C., Olczak M., Olczak T.
    Academic press:
    Immunobiology (rok: 2016, tom: 221, strony: 1382-1394), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.imbio.2016.07.007 - link to the publication
  5. Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties
    Authors:
    Bielecki M, Antonyuk S, Strange RW, Smalley JW, Mackiewicz P, Śmiga M, Stępień P, Olczak M, Olczak T
    Academic press:
    Bioscience Reports (rok: 2018, tom: 38(5), strony: BSR20181325), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BSR20181325 - link to the publication