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Regulation of mitochondrial potassium channels by gaseous signaling molecules: NO, CO and H2S

2015/17/B/NZ1/02496

Keywords

Descriptors

  • NZ1_3: Biofizyka
  • NZ1_2: Biochemia
  • NZ1_1: Biologia molekularna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Adam Michał Szewczyk

Number of co-investigators in the project: 4

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
1 251 000 PLN
Project start date
2016-02-18
Project end date
2020-02-17
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer. Cost: 15 000 PLN
  2. Oprogramowanie do analizy danych elektrofizjologicznych - pCLAMP. Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (8)

  1. A large-conductance calcium-regulated K+ channel in human dermal fibroblast mitochondria.

    Authors:
    Kicinska A, Augustynek B, Kulawiak B, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P
    Academic press:
    Biochemical Journal (year: 2016, volume: 473, pages: 4457-4471), Publisher: Biochemical Society/Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20160732 – link to the publication

  2. Single-channel properties of the ROMK-pore-forming subunit of the mitochondrial ATP-sensitive potassium channel.

    Authors:
    Michal Laskowski, Bartlomiej Augustynek, Piotr Bednarczyk, Monika Zochowska, Justyna Kalisz, Brian O'Rourke, Adam Szewczyk, Bogusz Kulawiak
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20, pages: 5323), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms201215323 – link to the publication

  3. Signaling pathways targeting mitochondrial potassium channels

    Authors:
    Daria Rotko, Wofram S. Kunz, Adam Szewczyk, Bogusz Kulawiak
    Academic press:
    The International Journal of Biochemistry and Cell Biology (year: 2020, volume: 125, pages: 105792), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2020.105792 – link to the publication

  4. Mechanosensitivity of mitochondrial large-conductance calcium-activated potassium channels

    Authors:
    Agnieszka Walewska, BoguszKUlawiak, Adam Szewczyk, Piotr Koprowski
    Academic press:
    Biochimica et Biophysica Acta Bioenergetics (year: 2018, volume: 1859, pages: 797-805), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2018.05.006 – link to the publication

  5. Gas singling molecules and mitochondrial potassium channels

    Authors:
    Agnieszka Walewska, Adam Szewczyk, Piotr Koprowski
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19, pages: 797-805), Publisher: MDPI
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2018.05.006 – link to the publication

  6. Energy-dissipating hub in muscle mitochondria: potassium channels and uncoupling proteins.

    Authors:
    Wieslawa Jarmuszkiewicz, Adam Szewczyk
    Academic press:
    Archives of Biochemistry and Biophysics (year: 2019, volume: 664, pages: 102-109), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2019.01.036 – link to the publication

  7. Targeting mitochondrial large-conductancecalcium-activated potassium channel by hydrogen sulphide via heme-binding site.

    Authors:
    Agnieszka Walewska, Adam Szewczyk, Milena Krajewska, Piotr Koprowski
    Academic press:
    The Journal of Pharmacology and Experimental Therapeutics (year: 2022, volume: 381, pages: 137-150), Publisher: The American Society forPharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/jpet.121.001017 – link to the publication

  8. Heme is required for carbon monoxide activation of mitochondrial BKCa channel.

    Authors:
    Daria Rotko, Piotr Bednarczyk, Piotr Koprowski, Wolfram S. Kunz, Adam Szewczyk
    Academic press:
    European Journal of Pharmacology (year: 2020, volume: 881, pages: 173191), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173191 – link to the publication

Articles in post-conference publications (22)

  1. Mitochondrial potassium channels in cardiac cells

    Authors:
    B. Kulawiak, M.Laskowski, B. Augustynek, P.Bednarczyk, A. Szewczyk
    Conference:
    New Frontiers in Basic Cardiovascular research: French - New EU Members (year: 2018, pages: 21), Publisher: Organizers
    Date:
    conference 11-14. 11
    Status:
    Published

  2. Mitochondrial Potassium Channels: regulation by gaseous transmitter.

    Authors:
    Adam Szewczyk, Agnieszka Walewska, Daria Rotko, Bogusz Kulawiak, Piotr Koprowski
    Conference:
    Biophysical Society Meeting (year: 2019, pages: 268a-269a), Publisher: Biophysical Society
    Date:
    conference 2-6 marzec
    Status:
    Published

  3. Regulation of the activity of mitochondrial large-conductance calcium-activated potassium channel by nitric oxide.

    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    8th Mitochondrion 2020 (year: 2020, pages: 40), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 5 luty
    Status:
    Published

  4. Potassium channels in cardiac mitochondria

    Authors:
    B. Kulawiak, M. Laskowski, B. Augustynek, M. Zochowska, P. Bednarczyk, A. Szewczyk
    Conference:
    7th Mitochondrion Mitochondria in the spotlight (year: 2018, pages: 44), Publisher: Faculty of Biotechnology University of Wroclaw
    Date:
    conference 18-19 October
    Status:
    Published

  5. Metal ion-substituted protoporphyrins as a tool to study regulation of the activity of mitoBKCa channel by hydrogen sulphide

    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    European Bioenergetic Conference EBEC (year: 2018, pages: e99-e100), Publisher: ELSEVIER
    Date:
    conference 25-30, 08
    Status:
    Published

  6. Production of functional Kir1.1b channels in protein-lipids nano discs.

    Authors:
    Agnieszka Kilebasa, Monika Krajewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    42nd FEBS Congress (year: 2017, pages: 152), Publisher: Wiley
    Date:
    conference 10-14 wrzesien
    Status:
    Published

  7. Identification of large-conductance calcium-regulated K channel in human dermal mitochondria

    Authors:
    Adam Szewczyk, Anna Kicinska, Bartlomiej Augustynek, Bogusz Kulawiak, Wieslawa Jarmuszkiewicz, Piotr Bednarczyk
    Conference:
    61st Annual Biophysical Society Meeting (year: 2017, pages: 406a), Publisher: Biophysical Society
    Date:
    conference 11-15 luty
    Status:
    Published

  8. The influence of substances modulating ATP-regulated potassium channel activity on oxygen consumption and membrane potential of isolated fibroblast mitochondria.

    Authors:
    Anna Kicinska, Piotr Bednarczyk, Adam Szewczyk, Wieslawa Jarmuszkiewicz
    Conference:
    6th Mitochondrion Bioenergetic Update (year: 2017, pages: 26), Publisher: Adam Mickiewicz University Poznan
    Date:
    conference 8 grudnia
    Status:
    Published

  9. Mitochondrial regulation of mitochondrial potassium channels

    Authors:
    Adam Szewczyk, Piotr Koprowski, Bogusz Kulawiak, Piotr Bednarczyk
    Conference:
    European Bioenergetic Conference EBEC (year: 2018, pages: e31), Publisher: Elsevier
    Date:
    conference 25-30. 08
    Status:
    Published

  10. Regulation of mitoBKca by H2S and heme

    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    6th MItochondrion Bioenergetic Update (year: 2017, pages: 19), Publisher: Adam Nickiewicz University Poznan
    Date:
    conference 8 grudnia
    Status:
    Published

  11. Mitochondrial regulation of mitochondrial potassium channels

    Authors:
    A. Szewczyk, B. Kulawiak, P. Bednarczy, P. Koprowski
    Conference:
    Congress Bio (year: 2018, pages: 49), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 18-21 wrzesien
    Status:
    Published

  12. H2S effects on the activity of mitoBKCa channels - dependence on protoporphyrin central metal ion.

    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    7th Mitochondrion Mitochondria in spotlight (year: 2018, pages: 44), Publisher: Faculty of Biotechnology, University of Warsaw
    Date:
    conference 18-19 October
    Status:
    Published

  13. Hydrogen sulfide regulates the activity of mitochondrial large conductance calcium activated potassium channels

    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    62nd Annual Meeting of Biophysical Society (year: 2018, pages: 131A), Publisher: Biophysical Society
    Date:
    conference 17-21 luty
    Status:
    Published

  14. Modulation of the mitochondrial potassium channel activity by infrared light

    Authors:
    A. Szewczyk, P. Bednarczyk,
    Conference:
    62nd Annual Meeting of the Biophysical Society (year: 2018, pages: 43A), Publisher: Biopysical Society
    Date:
    conference 17-21 luty
    Status:
    Published

  15. Diverse pharmacological effects of carbon monoxide-releasing molecules on mitochondrial BK channel

    Authors:
    D. Rotko, P. Bednarczyk, A. Szewczyk
    Conference:
    62nd Annual Meeting of the Biophysical Society (year: 2018, pages: 488A), Publisher: Biophysical Society
    Date:
    conference 17-21 luty
    Status:
    Published

  16. Single channel properties of the ROMK2 -pore -forming subunit of the mitochondrial ATP regulated potassium channel

    Authors:
    B. Kulawiak, M. Laskowski, B. AugusTYnek, P. Bednarczyk, A. Szewczyk
    Conference:
    Conbgress Bio (year: 2018, pages: 49), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 18-21 September
    Status:
    Published

  17. New properties of mitoBKCa channels

    Authors:
    Kulawiak B, Kielbasa A, Rotko D, Koprowski P, Szewczyk A
    Conference:
    AussieMit2016 (year: 2016, pages: 76), Publisher: Kolling Institute, Royal North Shore Hospital, Sydney, Australia
    Date:
    conference 26-28.11.2016
    Status:
    Published

  18. New properties of the mitochondrial large-conductance Ca2 +-activated K+ channel from astrocytoma mitochondria

    Authors:
    Daria Rotko, Piotr Bednarczyk, Piotr Koprowski, Adam Szewczyk
    Conference:
    EBEC 2016, European Bioenergetic Conference, Riva del Garda, July 2-7, 2016. (year: 2016, pages: e70-e71), Publisher: Elsevier
    Date:
    conference 2-7 Lipiec
    Status:
    Published

  19. Mechanosensitivity of mitochondrial large-conductance Ca2+-activated K+ channel

    Authors:
    Agnieszka Kiełbasa, Piotr Koprowski, Bogusz Kulawiak, Adam Szewczyk
    Conference:
    Bio 2016 Congress (year: 2016, pages: 158), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 13-16 września
    Status:
    Published
    DOI:
    link to the publication

  20. Regulation of the activity of mitochondrial large-conductance calcium-activated potassium channel by gasotransmitters.

    Authors:
    Agnieszka Walewska, Milena Krajewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    10th Targeting Mitochondria (year: 2019, pages: 165), Publisher: World Mitochondria Society
    Date:
    conference 28-29 październik
    Status:
    Published

  21. New regulatory mechanism of mitochondrial large-conductance calcium-activated potassium channel

    Authors:
    Agnieszka Walewska, Milena Krajewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    FEBS Congress (year: 2019, pages: 119), Publisher: FEBS Open Bio
    Date:
    conference 6-11 lipiec
    Status:
    Published

  22. Mitochondrial Potassium Channels and Cardioprotrection

    Authors:
    Adam Szewczyk
    Conference:
    FEPS-SIF 2019 (year: 2019, pages: -), Publisher: Italian Physiological Society
    Date:
    conference 10-13 wrzesień
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Guide to the Pharmacology of Mitochondrial Potassium Channels

    Authors:
    Augustynek B, Kunz WS, Szewczyk A
    Book:
    Handbook of Experimental Pharmacology (year: 2016, volume: 1, pages: 46047), Publisher: Springer International Publishing
    Status:
    Published
    DOI:
    link to the publication

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Graphic design and implementation: Jakub Piotrowski