Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Regulation of mitochondrial potassium channels by gaseous signaling molecules: NO, CO and H2S

2015/17/B/NZ1/02496

Keywords:

mitochondria potassium channels gaseous signaling molecules cytoprotection

Descriptors:

  • NZ1_3: Biophysics
  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Adam Szewczyk 

Number of co-investigators in the project: 4

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 251 000 PLN

Project start date (Y-m-d): 2016-02-18

Project end date (Y-m-d): 2020-02-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer (15 000 PLN)
  2. Oprogramowanie do analizy danych elektrofizjologicznych - pCLAMP (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (22)
  • Book publications / chapters in book publications (1)
  1. Energy-dissipating hub in muscle mitochondria: potassium channels and uncoupling proteins.
    Authors:
    Wieslawa Jarmuszkiewicz, Adam Szewczyk
    Academic press:
    Archives of Biochemistry and Biophysics (rok: 2019, tom: 664, strony: 102-109), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2019.01.036 - link to the publication
  2. Heme is required for carbon monoxide activation of mitochondrial BKCa channel.
    Authors:
    Daria Rotko, Piotr Bednarczyk, Piotr Koprowski, Wolfram S. Kunz, Adam Szewczyk
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 881, strony: 173191), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173191 - link to the publication
  3. Mechanosensitivity of mitochondrial large-conductance calcium-activated potassium channels
    Authors:
    Agnieszka Walewska, BoguszKUlawiak, Adam Szewczyk, Piotr Koprowski
    Academic press:
    Biochimica et Biophysica Acta Bioenergetics (rok: 2018, tom: 1859, strony: 797-805), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2018.05.006 - link to the publication
  4. Targeting mitochondrial large-conductancecalcium-activated potassium channel by hydrogen sulphide via heme-binding site.
    Authors:
    Agnieszka Walewska, Adam Szewczyk, Milena Krajewska, Piotr Koprowski
    Academic press:
    The Journal of Pharmacology and Experimental Therapeutics (rok: 2022, tom: 381, strony: 137-150), Wydawca: The American Society forPharmacology and Experimental Therapeutics
    Status:
    Published
    DOI:
    10.1124/jpet.121.001017 - link to the publication
  5. Signaling pathways targeting mitochondrial potassium channels
    Authors:
    Daria Rotko, Wofram S. Kunz, Adam Szewczyk, Bogusz Kulawiak
    Academic press:
    The International Journal of Biochemistry and Cell Biology (rok: 2020, tom: 125, strony: 105792), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2020.105792 - link to the publication
  6. A large-conductance calcium-regulated K+ channel in human dermal fibroblast mitochondria.
    Authors:
    Kicinska A, Augustynek B, Kulawiak B, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P
    Academic press:
    Biochemical Journal (rok: 2016, tom: 473, strony: 4457-4471), Wydawca: Biochemical Society/Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20160732 - link to the publication
  7. Gas singling molecules and mitochondrial potassium channels
    Authors:
    Agnieszka Walewska, Adam Szewczyk, Piotr Koprowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 797-805), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.1016/j.bbabio.2018.05.006 - link to the publication
  8. Single-channel properties of the ROMK-pore-forming subunit of the mitochondrial ATP-sensitive potassium channel.
    Authors:
    Michal Laskowski, Bartlomiej Augustynek, Piotr Bednarczyk, Monika Zochowska, Justyna Kalisz, Brian O'Rourke, Adam Szewczyk, Bogusz Kulawiak
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 5323), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms201215323 - link to the publication
  1. Diverse pharmacological effects of carbon monoxide-releasing molecules on mitochondrial BK channel
    Authors:
    D. Rotko, P. Bednarczyk, A. Szewczyk
    Conference:
    62nd Annual Meeting of the Biophysical Society (rok: 2018, ), Wydawca: Biophysical Society
    Data:
    konferencja 17-21 luty
    Status:
    Published
  2. Mitochondrial Potassium Channels and Cardioprotrection
    Authors:
    Adam Szewczyk
    Conference:
    FEPS-SIF 2019 (rok: 2019, ), Wydawca: Italian Physiological Society
    Data:
    konferencja 10-13 wrzesień
    Status:
    Published
  3. Mitochondrial regulation of mitochondrial potassium channels
    Authors:
    A. Szewczyk, B. Kulawiak, P. Bednarczy, P. Koprowski
    Conference:
    Congress Bio (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21 wrzesien
    Status:
    Published
  4. New regulatory mechanism of mitochondrial large-conductance calcium-activated potassium channel
    Authors:
    Agnieszka Walewska, Milena Krajewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    FEBS Congress (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 6-11 lipiec
    Status:
    Published
  5. Production of functional Kir1.1b channels in protein-lipids nano discs.
    Authors:
    Agnieszka Kilebasa, Monika Krajewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    42nd FEBS Congress (rok: 2017, ), Wydawca: Wiley
    Data:
    konferencja 10-14 wrzesien
    Status:
    Published
  6. The influence of substances modulating ATP-regulated potassium channel activity on oxygen consumption and membrane potential of isolated fibroblast mitochondria.
    Authors:
    Anna Kicinska, Piotr Bednarczyk, Adam Szewczyk, Wieslawa Jarmuszkiewicz
    Conference:
    6th Mitochondrion "Bioenergetic Update" (rok: 2017, ), Wydawca: Adam Mickiewicz University Poznan
    Data:
    konferencja 8 grudnia
    Status:
    Published
  7. H2S effects on the activity of mitoBKCa channels - dependence on protoporphyrin central metal ion.
    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    7th Mitochondrion "Mitochondria in spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology, University of Warsaw
    Data:
    konferencja 18-19 October
    Status:
    Published
  8. Mitochondrial Potassium Channels: regulation by gaseous transmitter.
    Authors:
    Adam Szewczyk, Agnieszka Walewska, Daria Rotko, Bogusz Kulawiak, Piotr Koprowski
    Conference:
    Biophysical Society Meeting (rok: 2019, ), Wydawca: Biophysical Society
    Data:
    konferencja 2-6 marzec
    Status:
    Published
  9. Mitochondrial potassium channels in cardiac cells
    Authors:
    B. Kulawiak, M.Laskowski, B. Augustynek, P.Bednarczyk, A. Szewczyk
    Conference:
    New Frontiers in Basic Cardiovascular research: French - New EU Members (rok: 2018, ), Wydawca: Organizers
    Data:
    konferencja 11-14. 11
    Status:
    Published
  10. Modulation of the mitochondrial potassium channel activity by infrared light
    Authors:
    A. Szewczyk, P. Bednarczyk,
    Conference:
    62nd Annual Meeting of the Biophysical Society (rok: 2018, ), Wydawca: Biopysical Society
    Data:
    konferencja 17-21 luty
    Status:
    Published
  11. Regulation of mitoBKca by H2S and heme
    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    6th MItochondrion "Bioenergetic Update" (rok: 2017, ), Wydawca: Adam Nickiewicz University Poznan
    Data:
    konferencja 8 grudnia
    Status:
    Published
  12. Regulation of the activity of mitochondrial large-conductance calcium-activated potassium channel by gasotransmitters.
    Authors:
    Agnieszka Walewska, Milena Krajewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    10th Targeting Mitochondria (rok: 2019, ), Wydawca: World Mitochondria Society
    Data:
    konferencja 28-29 październik
    Status:
    Published
  13. Mechanosensitivity of mitochondrial large-conductance Ca2+-activated K+ channel
    Authors:
    Agnieszka Kiełbasa, Piotr Koprowski, Bogusz Kulawiak, Adam Szewczyk
    Conference:
    Bio 2016 Congress (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13-16 września
    Status:
    Published
    DOI:
    link to the publication
  14. Metal ion-substituted protoporphyrins as a tool to study regulation of the activity of mitoBKCa channel by hydrogen sulphide
    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    European Bioenergetic Conference EBEC (rok: 2018, ), Wydawca: ELSEVIER
    Data:
    konferencja 25-30, 08
    Status:
    Published
  15. Potassium channels in cardiac mitochondria
    Authors:
    B. Kulawiak, M. Laskowski, B. Augustynek, M. Zochowska, P. Bednarczyk, A. Szewczyk
    Conference:
    7th Mitochondrion "Mitochondria in the spotlight" (rok: 2018, ), Wydawca: Faculty of Biotechnology University of Wroclaw
    Data:
    konferencja 18-19 October
    Status:
    Published
  16. Hydrogen sulfide regulates the activity of mitochondrial large conductance calcium activated potassium channels
    Authors:
    A. Walewska, P. Koprowski, A. Szewczyk
    Conference:
    62nd Annual Meeting of Biophysical Society (rok: 2018, ), Wydawca: Biophysical Society
    Data:
    konferencja 17-21 luty
    Status:
    Published
  17. Mitochondrial regulation of mitochondrial potassium channels
    Authors:
    Adam Szewczyk, Piotr Koprowski, Bogusz Kulawiak, Piotr Bednarczyk
    Conference:
    European Bioenergetic Conference EBEC (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 25-30. 08
    Status:
    Published
  18. New properties of mitoBKCa channels
    Authors:
    Kulawiak B, Kielbasa A, Rotko D, Koprowski P, Szewczyk A
    Conference:
    AussieMit2016 (rok: 2016, ), Wydawca: Kolling Institute, Royal North Shore Hospital, Sydney, Australia
    Data:
    konferencja 26-28.11.2016
    Status:
    Published
  19. New properties of the mitochondrial large-conductance Ca2 +-activated K+ channel from astrocytoma mitochondria
    Authors:
    Daria Rotko, Piotr Bednarczyk, Piotr Koprowski, Adam Szewczyk
    Conference:
    EBEC 2016, European Bioenergetic Conference, Riva del Garda, July 2-7, 2016. (rok: 2016, ), Wydawca: Elsevier
    Data:
    konferencja 2-7 Lipiec
    Status:
    Published
  20. Regulation of the activity of mitochondrial large-conductance calcium-activated potassium channel by nitric oxide.
    Authors:
    Agnieszka Walewska, Piotr Koprowski, Adam Szewczyk
    Conference:
    8th Mitochondrion 2020 (rok: 2020, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 5 luty
    Status:
    Published
  21. Identification of large-conductance calcium-regulated K channel in human dermal mitochondria
    Authors:
    Adam Szewczyk, Anna Kicinska, Bartlomiej Augustynek, Bogusz Kulawiak, Wieslawa Jarmuszkiewicz, Piotr Bednarczyk
    Conference:
    61st Annual Biophysical Society Meeting (rok: 2017, ), Wydawca: Biophysical Society
    Data:
    konferencja 11-15 luty
    Status:
    Published
  22. Single channel properties of the ROMK2 -pore -forming subunit of the mitochondrial ATP regulated potassium channel
    Authors:
    B. Kulawiak, M. Laskowski, B. AugusTYnek, P. Bednarczyk, A. Szewczyk
    Conference:
    Conbgress Bio (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 18-21 September
    Status:
    Published
  1. Guide to the Pharmacology of Mitochondrial Potassium Channels
    Authors:
    Augustynek B, Kunz WS, Szewczyk A
    Book:
    Handbook of Experimental Pharmacology (rok: 2016, tom: 1, strony: 45316), Wydawca: Springer International Publishing
    Status:
    Published
    DOI:
    link to the publication

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