Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Influence of neurotoxic factors on aspartate N-acetyltransferase activity in cholinergic neurons

2015/17/N/NZ3/01428

Keywords:

aspartate N-acetyltransferase N-acetylaspartate nitric oxide amyloid-B neurodegeneration

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marlena Zyśk 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-03-15

Project end date (Y-m-d): 2020-03-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Protective effects of voltage-gated calcium channel antagonists against zinc toxicity in SN56 neuroblastoma cholinergic cells
    Authors:
    Zyśk Marlena, Gapys Beata, Ronowska Anna, Gul-Hinc Sylwia, Eralndsson Anna, Iwanicki Adam, Sakowicz-Burkiewicz Monika, Szutowicz Andrzej, Bielarczyk Hanna
    Academic press:
    PLoS ONE (rok: 2018, tom: 13, strony: e0209363), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0209363 - link to the publication
  2. Phenotype-Dependent Interactions between N-acetyl-L-Aspartate and Acetyl-CoA in Septal SN56 Cholinergic Cells Exposed to an Excess of Zinc
    Authors:
    Zyśk Marlena, Bielarczyk Hanna, Gul-Hinc Sylwia, Dyś Aleksandra, Gapys Beata, Ronowska Anna, Sakowicz-Burkiewicz Monika, Szutowicz Andrzej
    Academic press:
    Journal of Alzheimer Disease (rok: 2017, tom: 56(3), strony: 1145-1158), Wydawca: IOS Press Journals
    Status:
    Published
    DOI:
    10.3233/JAD-160693 - link to the publication
  3. The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain
    Authors:
    Robert Kowalski, Piotr Pikul, Krzysztof Lewandowski, Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk, Marlena Zyśk
    Academic press:
    Antioxidants (rok: 2021, tom: 10(9), strony: 1404), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10091404 - link to the publication
  4. Neither Excessive Nitric Oxide Accumulation nor Acute Hyperglycemia Affects the N-Acetylaspartate Network in Wistar Rat Brain Cells
    Authors:
    Marlena Zyśk, Piotr Pikul, Robert Kowalski, Krzysztof Lewandowski, Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk
    Academic press:
    Journal of molecular Sciences (rok: 2020, tom: 21(22), strony: 8541), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21228541 - link to the publication
  5. The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons
    Authors:
    Marlena Zyśk, Monika Sakowicz-Burkiewicz, Piotr Pikul, Robert Kowalski, Anna Michno, Tadeusz Pawełczyk
    Academic press:
    Antioxidants (rok: 2020, tom: 9(6), strony: 522), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9060522 - link to the publication

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