Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Development of optimization methods for dose selection of analgesic drugs used as a combination drug therapy in neuropathic pain by artificial intelligence methods.

2015/17/B/NZ7/02937

Keywords:

neuropathic pain in vivo models oxaliplatin combination drug therapy of neuropathic pain Support Vector Regression genetic algorithms

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Uniwersytet Jagielloński - Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Kinga Sałat 

Number of co-investigators in the project: 8

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 441 800 PLN

Project start date (Y-m-d): 2016-02-12

Project end date (Y-m-d): 2021-02-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Analgezymetr dla swobodnie poruszających się myszy (34 869 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (17)
  1. Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-Induced Neuropathic Pain
    Authors:
    Furgała-Wojas A, Kowalska M, Nowaczyk M, Fijałkowski Ł, Sałat K
    Academic press:
    Current Drug Metabolism (rok: 2020, tom: 21(7), strony: 548-561), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1389200221666200711155632 - link to the publication
  2. Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain.
    Authors:
    Sałat K, Furgała A, Sałat R
    Academic press:
    Inflammopharmacology (rok: 2018, tom: 26, strony: 361-374), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10787-017-0405-5 - link to the publication
  3. Experimental drugs for neuropathic pain
    Authors:
    Sałat K, Gryzło B, Kulig K
    Academic press:
    Current Neuropharmacology (rok: 2018, tom: 16, strony: 1193-1209), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X16666180510151241 - link to the publication
  4. Wide-Range Measurement of Thermal Preference-A Novel Method for Detecting Analgesics Reducing Thermally-Evoked Pain in Mice
    Authors:
    Sałat K, Furgała-Wojas A, Awtoniuk M, Sałat R.
    Academic press:
    Molecules (rok: 2021, tom: 26(3), strony: 612), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26030612 - link to the publication
  5. Chemotherapy-Induced Peripheral Neuropathy - Part 2: Focus on the Prevention of Oxaliplatin-Induced Neurotoxicity
    Authors:
    Sałat K.
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72(3), strony: 508-527), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00106-1 - link to the publication
  6. Chemotherapy-Induced Peripheral Neuropathy – Part 1: Current State of Knowledge and Perspectives for Pharmacotherapy
    Authors:
    Sałat K
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72(3), strony: 486-507), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00109-y - link to the publication
  7. Interventional and preventive effects of aripiprazole and ceftriaxone used alone or in combination on oxaliplatin-induced tactile and cold allodynia in mice
    Authors:
    Sałat K, Furgała A, Sałat R
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2019, tom: 111, strony: 882-890), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2019.01.008 - link to the publication
  8. Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline
    Authors:
    Furgała A, Sałat R, Sałat K
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2018, tom: 78, strony: 315-321), Wydawca: Nencki Institute of Experimental Biology
    Status:
    Published
  9. Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress - A model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies.
    Authors:
    Malikowska N, Fijałkowski Ł, Nowaczyk A, Popik P, Sałat K
    Academic press:
    Brain Research (rok: 2017, tom: 1673, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.brainres.2017.08.001 - link to the publication
  10. Searching for analgesic drug candidates alleviating oxaliplatin - induced cold hypersensitivity in mice
    Authors:
    Sałat k, Furgała A, Malikowska-Racia N
    Academic press:
    Chemical Biology & Drug Design (rok: 2019, tom: 93(6), strony: 1061-1072), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/cbdd.13507 - link to the publication
  11. Potential role of selected antiepileptics used in neuropathic pain as human GABA transporter isoform 1 (GAT1) inhibitors-Molecular docking and pharmacodynamic studies.
    Authors:
    Fijałkowski Ł, Sałat K, Podkowa A, Zaręba P, Nowaczyk A
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2017, tom: 96, strony: 362-372), Wydawca: Elsevier
    Status:
    Published
  12. Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice
    Authors:
    Furgała A, Fijałkowski Ł, Nowaczyk A, Sałat R, Sałat K
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2018, tom: 106, strony: 930-940), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2018.07.039 - link to the publication
  1. Aktywność przeciwbólowa ambroksolu w leczeniu bólu neuropatycznego indukowanego oksaliplatyną
    Authors:
    Furgała A., Sałat K.
    Conference:
    IV Ogólnopolska Konferencja Studenckich Kół Naukowych i Doktorantów "W kręgu myśli Paracelsusa" (rok: 2019, ), Wydawca: Wydział Farmaceutyczny UJ CM
    Data:
    konferencja 43624
    Status:
    Published
  2. Impact of feature selection on system identification by means of NARX-SVM
    Authors:
    Awtoniuk M, Daniun M, Sałat K, Sałat R
    Conference:
    III International Conference of Computational Methods in Engineering Science (CMES'18) (rok: 2018, ), Wydawca: EDP Sciences
    Data:
    konferencja 22-24.11.2018
    Status:
    Published
  3. Aktywność przeciwbólowa rufinamidu i bupropionu w modelu bólu neuropatycznego indukowanego oksaliplatyną u myszy.
    Authors:
    Furgała A, Sałat K, Szczeblewska A, Podkowa A
    Conference:
    XXXI Ogólnopolskie Seminarium "Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych" (rok: 2017, ), Wydawca: Wydawnictwo Małopolska Szkoła Wyższa im. J. Dietla w Krakowie
    Data:
    konferencja 24.06.17
    Status:
    Published
  4. Antiallodynic and antihyperalgesic activity of ceftriaxone in a mouse model of neuropathic pain induced by oxaliplatin
    Authors:
    Furgała A, Sałat K
    Conference:
    31st ECNP Congress (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 6-9.09.2018
    Status:
    Published
  5. Antinociceptive and antiallodynic activity of ceftraixone and aripiprazole in oxaliplatin-treated mouse model of chemotherapy-induced peripheral neuropathy
    Authors:
    Furgała A., Sałat K.
    Conference:
    The 7th International Congress on Neuropathic Pain (NeuPSIG 2019) (rok: 2019, ), Wydawca: IASP
    Data:
    konferencja 2019-05-09-2019-05-11
    Status:
    Published
  6. Black-box identification of a pilot-scale dryer model: A Support Vector Regression and an Imperialist Competitive Algorithm approach
    Authors:
    Sałat R, Awtoniuk M, Korpysz K
    Conference:
    The 20th World Congress of the International Federation of Automatic Control, IFAC 2017 (rok: 2017, ), Wydawca: IFAC
    Data:
    konferencja 9-14.07.17
    Status:
    Published
  7. Study of time- and temperature-dependence of cold allodynia induced by oxaliplatin in CD-1 mice
    Authors:
    Furgała A, Sałat K.
    Conference:
    XXth International Congress for Medical Students and Young Doctors "MEDIS Timisoara 2017". (rok: 2017, ), Wydawca: University of Medicine and Pharmacy, Timisoara
    Data:
    konferencja 16-19.03.2017
    Status:
    Published
  8. Synergistic effect of sub-analgesic-dose ambroxol and pregabalin in oxaliplatin-induced cold allodynia
    Authors:
    Furgała A, Sałat K
    Conference:
    Neuronus 2018 Ibro Neuroscience Forum (rok: 2018, ), Wydawca: Neuronusforum
    Data:
    konferencja 20-22.04.2018
    Status:
    Published
  9. Analgesic activity of ambroxol and amitriptyline in a model of oxaliplatin-induced neuropathic pain in mice
    Authors:
    Furgała A, Sałat K
    Conference:
    2nd International Conference on Pharmaceutical and Medical Sciences, Poprad, Słowacja (rok: 2018, ), Wydawca: ZOZ Ośrodek UMEA Shinoda-Kuracejo
    Data:
    konferencja 21-23.09.2018
    Status:
    Published
  10. Analgesic activity of cebranopadol in acute and neuropathic pain models in mice
    Authors:
    Furgała A, Sałat K, Szczeblewska A, Gorol P, Filipek B
    Conference:
    9th Polish-German Symposium on Pharmaceutical Sciences 'Towards Novel Concepts in Pharmaceutical Sciences' (rok: 2017, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 26-27.05.17
    Status:
    Published
  11. Antiallodynic activity of cebranopadol and minocycline in combination with simvastatin in oxaliplatin-induced neuropathic pain model in mice.
    Authors:
    Furgała A, Szczybyło M, Sałat K
    Conference:
    The XXVI International Symposium "Molecular and Physiological Aspects of Regulatory Processes in the Organism" (rok: 2017, ), Wydawca: Abaton
    Data:
    konferencja 16.09.17
    Status:
    Published
  12. Combination drug therapy using duloxetine and ambroxol - a potential novel treatment option for oxaliplatin-induced peripheral neuropathy
    Authors:
    Furgała A., Sałat K.
    Conference:
    The 7th International Congress on Neuropathic Pain (NeuPSIG 2019) (rok: 2019, ), Wydawca: IASP
    Data:
    konferencja 2019-05-09-2019-05-11
    Status:
    Published
  13. Comparison of bromhexine and its active metabolite, ambroxol, for prevention and treatment of chemotherapy-induced neuropathic pain – a mouse study
    Authors:
    Sałat K, Furgała A., Sałat R.
    Conference:
    14th World Congress on Inflammation Sydney 2019 (rok: 2019, ), Wydawca: WCI
    Data:
    konferencja 2019-09-15-2019-09-19
    Status:
    Published
  14. Ocena przeciwbólowej aktywności simwastatyny w modelu bólu neuropatycznego indukowanego oksaliplatyną u myszy
    Authors:
    Furgała A, Sałat K
    Conference:
    XXIII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego "Farmacja w Polsce - perspektywy nauki i zawodu" (rok: 2017, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 19-22.09.17
    Status:
    Published
  15. Aktywność przeciwbólowa amboksolu w modelu bólu neuropatycznego indukowanego oksaliplatyną u myszy
    Authors:
    Furgała A, Sałat K
    Conference:
    XXXII Ogólnopolskie Seminarium " Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych" (rok: 2018, ), Wydawca: Małopolska Wyższa Szkoła im. J. Dietla w Krakowie
    Data:
    konferencja 23.06.2018
    Status:
    Published
  16. Combination drug therapy (minocycline/ambroxol) suppresses chemotherapy-induced neuropathic pain in mice
    Authors:
    Sałat K., Furgała A., Sałat R.
    Conference:
    14th World Congress on Inflammation Sydney 2019 (rok: 2019, ), Wydawca: WCI
    Data:
    konferencja 2019-09-15-2019-09-19
    Status:
    Published
  17. Comparison of the analgesic effect of bromhexine and ambroxol in the oxaliplatin model of chemotherapy-induced peripheral neuropathy
    Authors:
    Furgała A., Sałat K.
    Conference:
    32nd ECNP Congress (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 2019-09-07-2019-09-10
    Status:
    Published