Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of the Rho family in the regulation of actin cytoskeleton in podocytes. The influence on migration and filtration barrier permeability.

2015/17/B/NZ4/02658

Keywords:

podocyte insulin resistance migration RhoA kinase filtration barrier permeability F-actin dynamic

Descriptors:

  • NZ3_2: Cell physiology
  • NZ4_4: Pathophysiology
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Piwkowska 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 089 200 PLN

Project start date (Y-m-d): 2016-02-15

Project end date (Y-m-d): 2019-02-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator z wbudowanym systemem mikroskopii fluorescencyjnej (488 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
    Authors:
    Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Marlena Typiak, Tomasz Kulesza, Stefan Angielski, Michał Rychłowski, Magdalena Wysocka, Natalia Gruba, Adam Lesner, Moin A Saleem, Agnieszka Piwkowska
    Academic press:
    Biochim Biophys Acta Molecular Cell Research (rok: 2020, tom: 1867(8), strony: 118723), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2020.118723 - link to the publication
  2. Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions
    Authors:
    Maria Szrejder, Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Ewelina Kreft, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Biochim Biophys Acta Molecular Basis of Disease (rok: 2020, tom: 1866(3), strony: 165610), Wydawca: Elsewier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.165610 - link to the publication
  3. Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease.
    Authors:
    Piwkowska Agnieszka
    Academic press:
    Journal of Cellular Physiology (rok: 2016, tom: 232, strony: 691-697), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.25613 - link to the publication
  4. The PKGIα-Rac1 pathway is a novel regulator of insulin-dependent glucose uptake in cultured rat podocytes.
    Authors:
    Irena Audzeyenka, Dorota Rogacka, Patrycja Rachubik, Marlena Typiak, Michał Rychłowski, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Journal of Cellular Physiology (rok: 2020, tom: brak, strony: 45305), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.30188 - link to the publication
  5. The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.
    Authors:
    Rachubik P., Szrejder M., Rogacka D., Audzeyenka I., Rychłowski M., Angielski S., Piwkowska A.
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2018, tom: 51, strony: 393-410), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000495236 - link to the publication
  1. Insulin induces changes in RhoA phosphorylation through activation of PKGIα-dependent signaling pathways in cultured rat podocytes
    Authors:
    Rogacka D, Piwkowska A, Angielski S, Jankowski M
    Conference:
    11th International Podocyte Conference (rok: 2016, ), Wydawca: Karger
    Data:
    konferencja 3-6 kwiecień
    Status:
    Published
  2. High glucose concentration induces changes in actin cytoskeleton through activation of PKGIα-dependent signaling pathways in podocytes.
    Authors:
    Rogacka D, Piwkowska A, Angielski S, Jankowski M
    Conference:
    8th Conference on Advances in Diabetes and Insulin Therapy (rok: 2016, ), Wydawca: Advances in Diabetes and Insulin Theraphy
    Data:
    konferencja 21-23 kwietnia
    Status:
    Published
  3. Metformin via AMP-activated kinase (AMPK) regulates remodeling of the actin cytoskeleton in podocytes.
    Authors:
    Piwkowska A, Audzeyenka I., Szrejder M., Rachubik P., Angielski S., Rogacka D.
    Conference:
    Membrane Contact Sites in Health and Disease. (rok: 2018, ), Wydawca: EMBO
    Data:
    konferencja 21-25 wrzesień
    Status:
    Published
  4. TRPC6 regulates the insulin effect on podocyte cytoskeleton dynamics.
    Authors:
    Rogacka D., Rachubik P., Szrejder M., Rychłowski M., Angielski S., Piwkowska A
    Conference:
    53rd Annual Meeting of the European Association for the Study of Diabetes (rok: 2017, ), Wydawca: Springer
    Data:
    konferencja 11-15 wrzesień
    Status:
    Published

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