Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Role of the Rho family in the regulation of actin cytoskeleton in podocytes. The influence on migration and filtration barrier permeability.

2015/17/B/NZ4/02658

Keywords:

podocyte insulin resistance migration RhoA kinase filtration barrier permeability F-actin dynamic

Descriptors:

  • NZ3_2: Cell physiology
  • NZ4_4: Pathophysiology
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Piwkowska 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 089 200 PLN

Project start date (Y-m-d): 2016-02-15

Project end date (Y-m-d): 2019-02-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator z wbudowanym systemem mikroskopii fluorescencyjnej (488 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease.
    Authors:
    Piwkowska Agnieszka
    Academic press:
    Journal of Cellular Physiology (rok: 2016, tom: 232, strony: 691-697), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.25613 - link to the publication
  2. Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions
    Authors:
    Maria Szrejder, Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Ewelina Kreft, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Biochim Biophys Acta Molecular Basis of Disease (rok: 2020, tom: 1866(3), strony: 165610), Wydawca: Elsewier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.165610 - link to the publication
  3. The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.
    Authors:
    Rachubik P., Szrejder M., Rogacka D., Audzeyenka I., Rychłowski M., Angielski S., Piwkowska A.
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2018, tom: 51, strony: 393-410), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000495236 - link to the publication
  4. Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
    Authors:
    Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Marlena Typiak, Tomasz Kulesza, Stefan Angielski, Michał Rychłowski, Magdalena Wysocka, Natalia Gruba, Adam Lesner, Moin A Saleem, Agnieszka Piwkowska
    Academic press:
    Biochim Biophys Acta Molecular Cell Research (rok: 2020, tom: 1867(8), strony: 118723), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2020.118723 - link to the publication
  5. The PKGIα-Rac1 pathway is a novel regulator of insulin-dependent glucose uptake in cultured rat podocytes.
    Authors:
    Irena Audzeyenka, Dorota Rogacka, Patrycja Rachubik, Marlena Typiak, Michał Rychłowski, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Journal of Cellular Physiology (rok: 2020, tom: brak, strony: 45305), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.30188 - link to the publication
  1. Metformin via AMP-activated kinase (AMPK) regulates remodeling of the actin cytoskeleton in podocytes.
    Authors:
    Piwkowska A, Audzeyenka I., Szrejder M., Rachubik P., Angielski S., Rogacka D.
    Conference:
    Membrane Contact Sites in Health and Disease. (rok: 2018, ), Wydawca: EMBO
    Data:
    konferencja 21-25 wrzesień
    Status:
    Published
  2. TRPC6 regulates the insulin effect on podocyte cytoskeleton dynamics.
    Authors:
    Rogacka D., Rachubik P., Szrejder M., Rychłowski M., Angielski S., Piwkowska A
    Conference:
    53rd Annual Meeting of the European Association for the Study of Diabetes (rok: 2017, ), Wydawca: Springer
    Data:
    konferencja 11-15 wrzesień
    Status:
    Published
  3. Insulin induces changes in RhoA phosphorylation through activation of PKGIα-dependent signaling pathways in cultured rat podocytes
    Authors:
    Rogacka D, Piwkowska A, Angielski S, Jankowski M
    Conference:
    11th International Podocyte Conference (rok: 2016, ), Wydawca: Karger
    Data:
    konferencja 3-6 kwiecień
    Status:
    Published
  4. High glucose concentration induces changes in actin cytoskeleton through activation of PKGIα-dependent signaling pathways in podocytes.
    Authors:
    Rogacka D, Piwkowska A, Angielski S, Jankowski M
    Conference:
    8th Conference on Advances in Diabetes and Insulin Therapy (rok: 2016, ), Wydawca: Advances in Diabetes and Insulin Theraphy
    Data:
    konferencja 21-23 kwietnia
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy