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Role of the Rho family in the regulation of actin cytoskeleton in podocytes. The influence on migration and filtration barrier permeability.

2015/17/B/NZ4/02658

Keywords

Descriptors

  • NZ3_2: Fizjologia komórki
  • NZ4_4: Patofizjologia ogólna
  • NZ1_1: Biologia molekularna

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Agnieszka Piwkowska

Number of co-investigators in the project: 6

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
1 089 200 PLN
Project start date
2016-02-15
Project end date
2019-02-14
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator z wbudowanym systemem mikroskopii fluorescencyjnej. Cost: 488 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. The PKGIα-Rac1 pathway is a novel regulator of insulin-dependent glucose uptake in cultured rat podocytes.

    Authors:
    Irena Audzeyenka, Dorota Rogacka, Patrycja Rachubik, Marlena Typiak, Michał Rychłowski, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Journal of Cellular Physiology (year: 2020, volume: brak, pages: 46036), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.30188 – link to the publication

  2. Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.

    Authors:
    Irena Audzeyenka, Patrycja Rachubik, Dorota Rogacka, Marlena Typiak, Tomasz Kulesza, Stefan Angielski, Michał Rychłowski, Magdalena Wysocka, Natalia Gruba, Adam Lesner, Moin A Saleem, Agnieszka Piwkowska
    Academic press:
    Biochim Biophys Acta Molecular Cell Research (year: 2020, volume: 1867(8), pages: 118723), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2020.118723 – link to the publication

  3. Role of Protein Kinase G and Reactive Oxygen Species in the Regulation of Podocyte Function in Health and Disease.

    Authors:
    Piwkowska Agnieszka
    Academic press:
    Journal of Cellular Physiology (year: 2016, volume: 232, pages: 691-697), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/jcp.25613 – link to the publication

  4. Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions

    Authors:
    Maria Szrejder, Patrycja Rachubik, Dorota Rogacka, Irena Audzeyenka, Michał Rychłowski, Ewelina Kreft, Stefan Angielski, Agnieszka Piwkowska
    Academic press:
    Biochim Biophys Acta Molecular Basis of Disease (year: 2020, volume: 1866(3), pages: 165610), Publisher: Elsewier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.165610 – link to the publication

  5. The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.

    Authors:
    Rachubik P., Szrejder M., Rogacka D., Audzeyenka I., Rychłowski M., Angielski S., Piwkowska A.
    Academic press:
    Cellular Physiology and Biochemistry (year: 2018, volume: 51, pages: 393-410), Publisher: Karger
    Status:
    Published
    DOI:
    10.1159/000495236 – link to the publication

Articles in post-conference publications (4)

  1. High glucose concentration induces changes in actin cytoskeleton through activation of PKGIα-dependent signaling pathways in podocytes.

    Authors:
    Rogacka D, Piwkowska A, Angielski S, Jankowski M
    Conference:
    8th Conference on Advances in Diabetes and Insulin Therapy (year: 2016, pages: 52), Publisher: Advances in Diabetes and Insulin Theraphy
    Date:
    conference 21-23 kwietnia
    Status:
    Published

  2. Insulin induces changes in RhoA phosphorylation through activation of PKGIα-dependent signaling pathways in cultured rat podocytes

    Authors:
    Rogacka D, Piwkowska A, Angielski S, Jankowski M
    Conference:
    11th International Podocyte Conference (year: 2016, pages: 132: 245-291), Publisher: Karger
    Date:
    conference 3-6 kwiecień
    Status:
    Published

  3. Metformin via AMP-activated kinase (AMPK) regulates remodeling of the actin cytoskeleton in podocytes.

    Authors:
    Piwkowska A, Audzeyenka I., Szrejder M., Rachubik P., Angielski S., Rogacka D.
    Conference:
    Membrane Contact Sites in Health and Disease. (year: 2018, pages: P89), Publisher: EMBO
    Date:
    conference 21-25 wrzesień
    Status:
    Published

  4. TRPC6 regulates the insulin effect on podocyte cytoskeleton dynamics.

    Authors:
    Rogacka D., Rachubik P., Szrejder M., Rychłowski M., Angielski S., Piwkowska A
    Conference:
    53rd Annual Meeting of the European Association for the Study of Diabetes (year: 2017, pages: Vol. 60, S504), Publisher: Springer
    Date:
    conference 11-15 wrzesień
    Status:
    Published

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