Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Maturation, pharmacogenomics, and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of alpha-agonist in pediatric intensive care unit patients.

2015/17/B/NZ7/03032

Keywords:

pharmacokinetics phamracodynamics metabolomics personalized medicine

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ2_4: Metabolomics

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Wiczling 

Number of co-investigators in the project: 13

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 688 800 PLN

Project start date (Y-m-d): 2016-04-27

Project end date (Y-m-d): 2020-04-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer-Stacja Robocza (30 000 PLN)
  2. Laptop.
  3. Zestaw komputerowy.

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (6)
  1. Population Pharmacokinetic Model of Dexmedetomidine in a Heterogeneous Group of Patients
    Authors:
    Ber J, Wiczling P, Hołysz M, Klupczyńska A, Bartkowska-Śniatkowska A, Bieda K, Smuszkiewicz P, Nowicka M, Żurański Ł, Sobczyński P, Matysiak J, Grześkowiak E, Bienert A.
    Academic press:
    J Clin Pharmacol. (rok: 2020, ), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/jcph.1647 - link to the publication
  2. HPLC-MS/MS method for dexmedetomidine quantification with Design of Experiments approach: application to pediatric pharmacokinetic study
    Authors:
    Oliwia Szerkus, Wiktoria Struck-Lewicka, Marta Kordalewska, Ewa Bartosińska, Renata Bujak, Agnieszka Borsuk, Agnieszka Bienert, Alicja Bartkowska-Śniatkowska, Justyna Warzybok, Paweł Wiczling, Antoni Nasal, Roman Kaliszan, Michał Jan Markuszewski, Danuta Siluk.
    Academic press:
    Bioanalysis (rok: 2017, tom: 9, strony: 395-406), Wydawca: Future Science
    Status:
    Published
    DOI:
    10.4155/bio-2016-0242 - link to the publication
  3. How to model temporal changes in nontargeted metabolomics study : a Bayesian multilevel perspective
    Authors:
    Paweł Wiczling, Emilia Daghir-Wojtkowiak, Arlette Yumba Mpanga, Damian Szczesny, Roman Kaliszan, Michał Jan Markuszewski.
    Academic press:
    Journal of Separation Science (rok: 2017, tom: 40, strony: 4667-4676), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jssc.201700918 - link to the publication
  4. Maturation, pharmacogenomics and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of alpha‑agonist in pediatric intensive care unit patients
    Authors:
    J Bartkowiak-Wieczorek, J Mocarska, A Bartkowska-Śniatkowska, J Matysiak, A Klupczyńska, ZJ Kokot, P Wiczling, E Grześkowiak, A Bienert
    Academic press:
    Journal of Medical Sciences (rok: 2017, tom: 86, strony: 219-222), Wydawca: Poznan University of Medical Sciences
    Status:
    Published
    DOI:
    10.20883/jms.2016.147 - link to the publication
  5. Multilevel pharmacokinetics-driven modeling of metabolomics data
    Authors:
    Emilia Daghir-Wojtkowiak, Paweł Wiczling, Małgorzata Waszczuk-Jankowska, Roman Kaliszan, Michał Jan Markuszewski.
    Academic press:
    Metabolomics (rok: 2017, tom: 13, strony: 45304), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11306-017-1164-4 - link to the publication
  6. Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits.
    Authors:
    Warzybok J, Bienert A, Borsuk-De Moor A, Płotek W, Kulińska K, Czerniak K, Billert H, Klupczyńska A, Matysiak J, Grześkowiak E, Wiczling P.
    Academic press:
    1,663 (rok: 2020, ), Wydawca: Biopharmaceutics & Drug Disposition
    Status:
    Published
    DOI:
    10.1002/bdd.2248 - link to the publication
  7. Pharmacokinetics of dexmedetomidine during analgosedation in ICU patients
    Authors:
    Piotr Smuszkiewicz, Paweł Wiczling, Justyna Ber, Justyna Warzybok, Tomasz Małkiewicz, Jan Matysiak, Agnieszka Klupczyńska, Iwona Trojanowska, Zenon Kokot, Edmund Grześkowiak, Wojciech Krzyzanski, Agnieszka Bienert
    Academic press:
    Journal of Pharmacokinetics and Pharmacodynamics (rok: 2018, tom: 48, strony: 277-284), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10928-017-9564-7 - link to the publication
  8. The pharmacodynamics of dexmedetomidine in elderly cardiac patients undergoing analgosedation in the ICU
    Authors:
    J Ber, M Malec, A Bienert, M Nowicka, Ł Żurański, E Grześkowiak, R Hartmann-Sobczyńska, P Sobczyński
    Academic press:
    Journal of Medical Science (rok: 2017, tom: 86, strony: 265-271), Wydawca: Poznan University of Medical Sciences
    Status:
    Published
    DOI:
    10.20883/jms.2017.264 - link to the publication
  9. The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors
    Authors:
    Wiczling P, Bartkowska-Śniatkowska A, Szerkus O, Siluk D, Rosada-Kurasińska J, Warzybok J, Borsuk A, Kaliszan R, Grześkowiak E, Bienert A
    Academic press:
    Journal of Pharmacokinetics and Pharmacodynamics (rok: 2016, tom: 43, strony: 315-324), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10928-016-9474-0 - link to the publication
  1. Dexmedetomidine determination in pediatric patients's plasma with the use of LC-MS/MS assay
    Authors:
    Oliwia Szerkus, Wiktoria Struck-Lewicka, Ewa Bartosińska, Marta Kordalewska, Renata Wawrzyniak, Agnieszka Borsuk-De Moor, Paweł Wiczling, Michał J. Markuszewski, Antoni Nasal, Roman Kaliszan, Danuta Siluk
    Conference:
    ITP 2017: 24th International Symposium on Electro- and Liquid Phase-Separation Techniques ; PKChrom 2017 : XI Polska Konferencja Chromatograficzna: "Chromatography in pharmacy and bioanalysis" (rok: 2017, ), Wydawca: bd
    Data:
    konferencja 10-13 September 2017
    Status:
    Published
  2. The Bayesian population pharmacokinetic analysis of dexmedetomidine and clonidine in Stan and Torsten
    Authors:
    P Wiczling, A Bartkowska-Śniatkowska, J Mocarska, P Sobczyński, A Bienert
    Conference:
    41st Annual Conference of the International Society for Clinical Biostatistics (rok: 2020, ), Wydawca: ISCB41
    Data:
    konferencja 23-27 August 2020
    Status:
    Published
  3. A Bayesian approach for population pharmacokinetic modeling of dexmedetomidine during long-term infusion in critically ill pediatric patients.
    Authors:
    P. Wiczling
    Conference:
    PAGE meeting (rok: 2016, ), Wydawca: PAGE meeting
    Data:
    konferencja 7-10 June
    Status:
    Published
    DOI:
    link to the publication
  4. How to model time-series data from non-targeted metabolomics study? : multilevel Bayesian approach
    Authors:
    Emilia Daghir-Wojtkowiak, Paweł Wiczling, Arlette Yumba Mpanga, Damian Szczesny, Roman Kaliszan, Michał Jan Markuszewski.
    Conference:
    ITP 2017 : 24th International Symposium on Electro- and Liquid Phase-Separation Techniques ; PKChrom 2017 : XI Polska Konferencja Chromatograficzna : "Chromatography in pharmacy and bioanalysis" (rok: 2017, ), Wydawca: bd
    Data:
    konferencja 10-13 September 2017
    Status:
    Published
  5. Pharmacokinetics of dexmedetomidine in elderly patients undergoing sedation after abdominal aortic surgery.
    Authors:
    Agnieszka Bienert, Paweł Wiczling, Justyna Mocarska, Łukasz Zuranski, Małgorzata Nowicka, Roma Hartmann-Sobczynska (3) Marcin Hołysz, Jan Matysiak, Agnieszka Klupczynska, Edmund Grześkowiak, Paweł Sobczynski
    Conference:
    PAGE meeting (rok: 2018, ), Wydawca: PAGE meeting
    Data:
    konferencja 29 May - 1 June, 2018
    Status:
    Published
    DOI:
    link to the publication
  6. The pharmacokinetics of propofol in ICU patients undergoing long-term sedation
    Authors:
    A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak
    Conference:
    ESICM2016 (rok: 2016, ), Wydawca: ESICM2016
    Data:
    konferencja 15-17 June
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy