Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Maturation, pharmacogenomics, and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of alpha-agonist in pediatric intensive care unit patients.

2015/17/B/NZ7/03032

Keywords:

pharmacokinetics phamracodynamics metabolomics personalized medicine

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ2_4: Metabolomics

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Wiczling 

Number of co-investigators in the project: 13

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 688 800 PLN

Project start date (Y-m-d): 2016-04-27

Project end date (Y-m-d): 2020-04-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop.
  2. Komputer-Stacja Robocza (30 000 PLN)
  3. Zestaw komputerowy.

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (6)
  1. Pharmacokinetics of dexmedetomidine during analgosedation in ICU patients
    Authors:
    Piotr Smuszkiewicz, Paweł Wiczling, Justyna Ber, Justyna Warzybok, Tomasz Małkiewicz, Jan Matysiak, Agnieszka Klupczyńska, Iwona Trojanowska, Zenon Kokot, Edmund Grześkowiak, Wojciech Krzyzanski, Agnieszka Bienert
    Academic press:
    Journal of Pharmacokinetics and Pharmacodynamics (rok: 2018, tom: 48, strony: 277-284), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10928-017-9564-7 - link to the publication
  2. Population analysis to assess the influence of age and body weight on pharmacokinetics and pharmacodynamics of dexmedetomidine in New Zealand White rabbits.
    Authors:
    Warzybok J, Bienert A, Borsuk-De Moor A, Płotek W, Kulińska K, Czerniak K, Billert H, Klupczyńska A, Matysiak J, Grześkowiak E, Wiczling P.
    Academic press:
    1,663 (rok: 2020, ), Wydawca: Biopharmaceutics & Drug Disposition
    Status:
    Published
    DOI:
    10.1002/bdd.2248 - link to the publication
  3. The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors
    Authors:
    Wiczling P, Bartkowska-Śniatkowska A, Szerkus O, Siluk D, Rosada-Kurasińska J, Warzybok J, Borsuk A, Kaliszan R, Grześkowiak E, Bienert A
    Academic press:
    Journal of Pharmacokinetics and Pharmacodynamics (rok: 2016, tom: 43, strony: 315-324), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10928-016-9474-0 - link to the publication
  4. Multilevel pharmacokinetics-driven modeling of metabolomics data
    Authors:
    Emilia Daghir-Wojtkowiak, Paweł Wiczling, Małgorzata Waszczuk-Jankowska, Roman Kaliszan, Michał Jan Markuszewski.
    Academic press:
    Metabolomics (rok: 2017, tom: 13, strony: 45304), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11306-017-1164-4 - link to the publication
  5. Maturation, pharmacogenomics and metabolomics as factors determining pharmacokinetic and pharmacodynamics profile of alpha‑agonist in pediatric intensive care unit patients
    Authors:
    J Bartkowiak-Wieczorek, J Mocarska, A Bartkowska-Śniatkowska, J Matysiak, A Klupczyńska, ZJ Kokot, P Wiczling, E Grześkowiak, A Bienert
    Academic press:
    Journal of Medical Sciences (rok: 2017, tom: 86, strony: 219-222), Wydawca: Poznan University of Medical Sciences
    Status:
    Published
    DOI:
    10.20883/jms.2016.147 - link to the publication
  6. HPLC-MS/MS method for dexmedetomidine quantification with Design of Experiments approach: application to pediatric pharmacokinetic study
    Authors:
    Oliwia Szerkus, Wiktoria Struck-Lewicka, Marta Kordalewska, Ewa Bartosińska, Renata Bujak, Agnieszka Borsuk, Agnieszka Bienert, Alicja Bartkowska-Śniatkowska, Justyna Warzybok, Paweł Wiczling, Antoni Nasal, Roman Kaliszan, Michał Jan Markuszewski, Danuta Siluk.
    Academic press:
    Bioanalysis (rok: 2017, tom: 9, strony: 395-406), Wydawca: Future Science
    Status:
    Published
    DOI:
    10.4155/bio-2016-0242 - link to the publication
  7. Population Pharmacokinetic Model of Dexmedetomidine in a Heterogeneous Group of Patients
    Authors:
    Ber J, Wiczling P, Hołysz M, Klupczyńska A, Bartkowska-Śniatkowska A, Bieda K, Smuszkiewicz P, Nowicka M, Żurański Ł, Sobczyński P, Matysiak J, Grześkowiak E, Bienert A.
    Academic press:
    J Clin Pharmacol. (rok: 2020, ), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/jcph.1647 - link to the publication
  8. How to model temporal changes in nontargeted metabolomics study : a Bayesian multilevel perspective
    Authors:
    Paweł Wiczling, Emilia Daghir-Wojtkowiak, Arlette Yumba Mpanga, Damian Szczesny, Roman Kaliszan, Michał Jan Markuszewski.
    Academic press:
    Journal of Separation Science (rok: 2017, tom: 40, strony: 4667-4676), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/jssc.201700918 - link to the publication
  9. The pharmacodynamics of dexmedetomidine in elderly cardiac patients undergoing analgosedation in the ICU
    Authors:
    J Ber, M Malec, A Bienert, M Nowicka, Ł Żurański, E Grześkowiak, R Hartmann-Sobczyńska, P Sobczyński
    Academic press:
    Journal of Medical Science (rok: 2017, tom: 86, strony: 265-271), Wydawca: Poznan University of Medical Sciences
    Status:
    Published
    DOI:
    10.20883/jms.2017.264 - link to the publication
  1. Pharmacokinetics of dexmedetomidine in elderly patients undergoing sedation after abdominal aortic surgery.
    Authors:
    Agnieszka Bienert, Paweł Wiczling, Justyna Mocarska, Łukasz Zuranski, Małgorzata Nowicka, Roma Hartmann-Sobczynska (3) Marcin Hołysz, Jan Matysiak, Agnieszka Klupczynska, Edmund Grześkowiak, Paweł Sobczynski
    Conference:
    PAGE meeting (rok: 2018, ), Wydawca: PAGE meeting
    Data:
    konferencja 29 May - 1 June, 2018
    Status:
    Published
    DOI:
    link to the publication
  2. The pharmacokinetics of propofol in ICU patients undergoing long-term sedation
    Authors:
    A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak
    Conference:
    ESICM2016 (rok: 2016, ), Wydawca: ESICM2016
    Data:
    konferencja 15-17 June
    Status:
    Published
  3. The Bayesian population pharmacokinetic analysis of dexmedetomidine and clonidine in Stan and Torsten
    Authors:
    P Wiczling, A Bartkowska-Śniatkowska, J Mocarska, P Sobczyński, A Bienert
    Conference:
    41st Annual Conference of the International Society for Clinical Biostatistics (rok: 2020, ), Wydawca: ISCB41
    Data:
    konferencja 23-27 August 2020
    Status:
    Published
  4. A Bayesian approach for population pharmacokinetic modeling of dexmedetomidine during long-term infusion in critically ill pediatric patients.
    Authors:
    P. Wiczling
    Conference:
    PAGE meeting (rok: 2016, ), Wydawca: PAGE meeting
    Data:
    konferencja 7-10 June
    Status:
    Published
    DOI:
    link to the publication
  5. Dexmedetomidine determination in pediatric patients's plasma with the use of LC-MS/MS assay
    Authors:
    Oliwia Szerkus, Wiktoria Struck-Lewicka, Ewa Bartosińska, Marta Kordalewska, Renata Wawrzyniak, Agnieszka Borsuk-De Moor, Paweł Wiczling, Michał J. Markuszewski, Antoni Nasal, Roman Kaliszan, Danuta Siluk
    Conference:
    ITP 2017: 24th International Symposium on Electro- and Liquid Phase-Separation Techniques ; PKChrom 2017 : XI Polska Konferencja Chromatograficzna: "Chromatography in pharmacy and bioanalysis" (rok: 2017, ), Wydawca: bd
    Data:
    konferencja 10-13 September 2017
    Status:
    Published
  6. How to model time-series data from non-targeted metabolomics study? : multilevel Bayesian approach
    Authors:
    Emilia Daghir-Wojtkowiak, Paweł Wiczling, Arlette Yumba Mpanga, Damian Szczesny, Roman Kaliszan, Michał Jan Markuszewski.
    Conference:
    ITP 2017 : 24th International Symposium on Electro- and Liquid Phase-Separation Techniques ; PKChrom 2017 : XI Polska Konferencja Chromatograficzna : "Chromatography in pharmacy and bioanalysis" (rok: 2017, ), Wydawca: bd
    Data:
    konferencja 10-13 September 2017
    Status:
    Published

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