Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The significance of cell senescence and polyploidy in the life cycle of cancer;in vitro studies

2015/17/B/NZ3/03531

Keywords:

atypical cell divisions mTOR Pim-1,reactive oxygen species

Descriptors:

  • NZ3_1:
  • NZ3_4:
  • NZ3_8:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Zofia Sikora 

Number of co-investigators in the project: 8

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 237 000 PLN

Project start date (Y-m-d): 2016-02-18

Project end date (Y-m-d): 2020-12-17

Project duration:: 58 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 do hodowli komórek (40 000 PLN)
  2. Wysokiej rozdzielczości czarno-biała kamera do odwróconego mikroskopu fluorescencyjnego Nikon Eclipse Ti-U (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (17)
  1. Therapy-induced polyploidization and senescence: Coincidence or interconnection?
    Authors:
    Sikora E, Czarnecka-Herok J, Bojko A, Sunderland P
    Academic press:
    Semin Cancer Biol (rok: 2020, tom: Dec 1;S1044-579, strony: 30253-4), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.semcancer.2020.11.015 - link to the publication
  2. The role of autophagy in escaping therapy-induced polyploidy/senescence
    Authors:
    Dudkowska M., Staniak K. Bojko A., Sikora E.
    Academic press:
    Advances in Cancer Research (rok: 2021, tom: 150, strony: 209-247), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.acr.2021.01.004 - link to the publication
  3. Targeting normal and cancer senescent cells as a strategy of senotherapy
    Authors:
    Sikora E, Bielak-Zmijewska A, Mosieniak G
    Academic press:
    Aeging Res Rev (rok: 2019, tom: Nov;55:., strony: 100941), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2019.100941 - link to the publication
  4. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells.
    Authors:
    Strzeszewska A, Alster O, Mosieniak G, Ciolko A, Sikora E
    Academic press:
    Cell Death Dis (rok: 2018, tom: 9(2), strony: 44), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41419-017-0069-5 - link to the publication
  5. Is DNA damage indispensable for stress-induced senescence?
    Authors:
    Bielak-Zmijewska A, Mosieniak G, Sikora E
    Academic press:
    Mech Ageing Dev. (rok: 2018, tom: 170, strony: 13-21), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mad.2017.08.004 - link to the publication
  6. Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells
    Authors:
    Bojko A, Staniak K, Czarnecka-Herok J, Sunderland P, Dudkowska M, Śliwińska MA, Salmina K, Sikora E
    Academic press:
    Int J Mol Sci. 2020 (rok: 2020, tom: Aug 24;21(17), strony: 6084), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176084 - link to the publication
  7. Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells
    Authors:
    Bojko A, Staniak K, Czarnecka-Herok J, Sunderland P, Dudkowska M, Śliwińska MA, Salmina K, Sikora E
    Academic press:
    Int J Mol Sci. 2020 (rok: 2020, tom: Aug 24;21(17), strony: 6084), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21176084 - link to the publication
  8. "Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
    Authors:
    Salmina K, Bojko A, Inashkina I, Staniak K, Dudkowska M, Podlesniy P, Rumnieks F, Vainshelbaum NM, Pjanova D, Sikora E, Erenpreisa J
    Academic press:
    Int J Mol Sci (rok: 2020, tom: Apr 16;21(8), strony: 2779), Wydawca: MDP!
    Status:
    Published
    DOI:
    10.3390/ijms21082779 - link to the publication
  9. Is DNA damage indispensable for stress-induced senescence?
    Authors:
    Bielak-Zmijewska A, Mosieniak G, Sikora E
    Academic press:
    Mech Ageing Dev. (rok: 2018, tom: 170, strony: 13-21), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mad.2017.08.004 - link to the publication
  10. Simultaneous induction and blockade of autophagy by a single agent.
    Authors:
    Kucharewicz K, Dudkowska M, Zawadzka A, Ogrodnik M, Szczepankiewicz AA, Czarnocki Z, Sikora E
    Academic press:
    Cell Death Dis (rok: 2018, tom: 9(3), strony: 353), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41419-018-0383-6 - link to the publication
  11. Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response
    Authors:
    Anna Strzeszewska-Potyrała, Karolina Staniak, Joanna Czarnecka-Herok, Mahmoud-Reza Rafiee , Marcin Herok , Grażyna Mosieniak , Jeroen Krijgsveld , Ewa Sikora
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13(9), strony: 2115), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13092115 - link to the publication
  12. Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents. .
    Authors:
    Bojko A, Czarnecka-Herok J, Charzynska A, Dabrowski M, Sikora E.
    Academic press:
    Cells (rok: 2019, tom: 8(12), strony: E1501), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells812150 - link to the publication
  13. Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response
    Authors:
    Anna Strzeszewska-Potyrała, Karolina Staniak, Joanna Czarnecka-Herok, Mahmoud-Reza Rafiee , Marcin Herok , Grażyna Mosieniak , Jeroen Krijgsveld , Ewa Sikora
    Academic press:
    Cancers (Basel) (rok: 2021, tom: 13(9), strony: 2115), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13092115 - link to the publication
  14. The role of autophagy in escaping therapy-induced polyploidy/senescence
    Authors:
    Dudkowska M., Staniak K. Bojko A., Sikora E.
    Academic press:
    Advances in Cancer Research (rok: 2021, tom: 150, strony: 209-247), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/bs.acr.2021.01.004 - link to the publication
  15. Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents. .
    Authors:
    Bojko A, Czarnecka-Herok J, Charzynska A, Dabrowski M, Sikora E.
    Academic press:
    Cells (rok: 2019, tom: 8(12), strony: E1501), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells812150 - link to the publication
  16. Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells.
    Authors:
    Strzeszewska A, Alster O, Mosieniak G, Ciolko A, Sikora E
    Academic press:
    Cell Death Dis (rok: 2018, tom: 9(2), strony: 44), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41419-017-0069-5 - link to the publication
  17. "Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
    Authors:
    Salmina K, Bojko A, Inashkina I, Staniak K, Dudkowska M, Podlesniy P, Rumnieks F, Vainshelbaum NM, Pjanova D, Sikora E, Erenpreisa J
    Academic press:
    Int J Mol Sci (rok: 2020, tom: Apr 16;21(8), strony: 2779), Wydawca: MDP!
    Status:
    Published
    DOI:
    10.3390/ijms21082779 - link to the publication

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