Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Analytical methodology for investigation of the cellular speciation of theranostic metal-based nanomaterials: development, optimization, and in-vitro application

2015/17/B/ST4/03707

Keywords:

theranostic metal-based nanomaterials hyphenated techniques mass spectrometry capillary electrophoresis in vitro investigations

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • ST4_8: Organic chemistry
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Jarosz 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 972 400 PLN

Project start date (Y-m-d): 2016-02-01

Project end date (Y-m-d): 2020-01-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do elektroforezy kapilarnej z detekcją UV/Vis z dedykowanym oprogramowaniem i jednostką komputerową oraz termostatem autosamplera i 3 kasetami (w tym 2 CE-MS) (370 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Book publications / chapters in book publications (1)
  1. Joint forces of direct, single particle, CE– and HPLC–inductively coupled plasma mass spectrometry techniques for the examination of gold nanoparticle accumulation, distribution and changes inside human cells
    Authors:
    J. Kruszewska, D. Kulpińska, I. Grabowska-Jadach, M. Matczuk
    Academic press:
    Metallomics (rok: 2020, tom: 12, strony: 408-415), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9mt00309f - link to the publication
  2. CE Separation and ICP-MS Detection of Gold Nanoparticles and Their Protein Conjugates
    Authors:
    Joanna Legat, Magdalena Matczuk, Federica Scaletti, Luigi Messori, Andrei Timerbaev, Maciej Jarosz
    Academic press:
    Chromatographia (rok: 2017, tom: 80, strony: 1695-1700), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10337-017-3387-y - link to the publication
  3. Characterization of interactions of metal-containing nanoparticles with biomolecules by CE: An update (2012–2016)
    Authors:
    Svetlana Aleksenko, Magdalena Matczuk, Aandrei Timerbaev
    Academic press:
    Electrophoresis (rok: 2016, tom: 38, strony: 1661-1668), Wydawca: WILEY-VCH Verlag GmbH & Co. KGaA
    Status:
    Published
    DOI:
    10.1002/elps.201700132 - link to the publication
  4. Nanocząstki złota, jako potencjalne metalo-nanomateriały teranostyczne – właściwości oraz analiza za pomocą ICP-MS
    Authors:
    M. Matczuk, A. Kur, J. Legat, L. Ruzik
    Academic press:
    Laboratorium - Przegląd Ogólnopolski (rok: 2018, tom: 2, strony: 26-33), Wydawca: Elamed
    Status:
    Published
    DOI:
    brak - link to the publication
  5. The fate of differently functionalized gold nanorods in human serum: A response from CE-ICP-MS
    Authors:
    M. Matczuk, J. Legat, F. Scaletti, L. Messori, A.R. Timerbaev, M. Jarosz
    Academic press:
    Journal of Chromatography A (rok: 2017, tom: 1499, strony: 222-225), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2017.03.081 - link to the publication
  6. An improved protocol for ICP-MS-based assessment of the cellular uptake of metal-based nanoparticles
    Authors:
    J. Kruszewska, A. Kur, D. Kulpińska, I. Grabowska-Jadach, M. Matczuk, B. Keppler, A.R. Timerbaev, M. Jarosz
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2019, tom: 174, strony: 300-304), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2019.06.006 - link to the publication
  7. Analytical methodology for studying cellular uptake, processing and localization of gold nanoparticles
    Authors:
    M. Matczuk, L. Ruzik, S.S. Aleksenko, B.K. Keppler, M. Jarosz, A.R. Timerbaev
    Academic press:
    Analytica Chimica Acta (rok: 2019, tom: 1052, strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.027 - link to the publication
  8. Cellular processing of gold nanoparticles: CE-ICP-MS evidence for the speciation changes in human cytosol
    Authors:
    Joanna Legat, Magdalena Matczuk, Andrei R. Timerbaev, Maciej Jarosz
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2018, tom: 410, strony: 1151–1156), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
    DOI:
    10.1007/s00216-017-0749-0 - link to the publication
  9. Characterization of quantum dots in cancer cytosol using ICP-MS-based combined techniques
    Authors:
    J. Kruszewska, M .Matczuk, S. Skorupska, I. Grabowska-Jadach, E. Pérez Hernández, A.R. Timerbaev, M. Jarosz
    Academic press:
    Analytical Biochemistry (rok: 2019, tom: 584, strony: 113387_1-113387_5), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2019.113387 - link to the publication
  10. Characterization of the protein corona of gold nanoparticles by an advanced treatment of CE-ICP-MS data
    Authors:
    M. Matczuk, J. Legat, S. N. Shtykov, M. Jarosz, A. R. Timerbaev
    Academic press:
    Electrophoresis (rok: 2016, tom: 37, strony: 2257-2259), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/elps.201600152 - link to the publication
  1. Matalonanomateriały w matrycach biologicznych
    Authors:
    J. Kruszewska, J. Wojcieszek, M. Matczuk, L. Ruzik, M. Jarosz
    Book:
    Bioanalityka (rok: 2020, tom: 1, strony: 401-413), Wydawca: Wydawnictwo Naukowe PWN S.A.
    Status:
    Published

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