Projects funded by the NCN
Relatioship between activation of FGFR-mediated signalling and loss of progesterone receptor in estrogen receptor-positive breast cancer: implications for tumour prognostication and therapy.
2015/17/B/NZ4/02157
Keywords:
breast cancer type luminal B progesterone receptor FGFR
Descriptors:
- NZ4_5: Anatomical pathology
- NZ3_1: Cell biology
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Uniwersytet Medyczny w Łodzi, Katedra Onkologii, Zakład Patologii
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 6
Call: OPUS 9 - announced on 2015-03-16
Amount awarded: 1 079 200 PLN
Project start date (Y-m-d): 2016-03-09
Project end date (Y-m-d): 2021-03-08
Project duration:: 60 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- b.d..
- chłodziarka laboratoryjna.
- wirówka.
- analogowy blok grzewczy.
- statyw magnetyczny.
- CFX Connect System 2.
- Przystawka do fitra wody (16 000 PLN)
- wizualizator chemiluminescencji (77 000 PLN)
- wytrząsarka laboratoryjna (7 000 PLN)
- hulamixer.
- spektrofotometr NanoDrop.
- wytrząsarka o ruchu okrężno-kołowym.
Information in the final report
- Publication in academic press/journals (5)
- FGFR2-driven signalling abrogates tamoxifen effect on ERalpha-positive breast cancer cellsAuthors:Lukasz Turczyk; Kamila Kitowska; Magdalena Mieszkowska; Kamil Mieczkowski; Dominika Czaplinska; Dominika Piasecka; Radzislaw Kordek; Andrzej Skladanowski; Piotr Potemski; Hanna Romanska; Rafal SadejAcademic press:Neoplasia (rok: 2017, tom: 19, strony: 791-804), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.neo.2017.07.006 - link to the publication
- MicroRNAs in regulation of triple-negative breast cancer progressionAuthors:Piasecka, Dominika, Braun, Marcin, Kordek, Radzislaw, Sadej, Rafal, Romanska, HannaAcademic press:Journal of Cancer Research and Clinical Oncology (rok: 2018, tom: 144(8), strony: 1401-1411), Wydawca: SpringerStatus:PublishedDOI:10.1007/s00432-018-2689-2 - link to the publication
- FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors - implications for therapy of luminal breast cancerAuthors:Piasecka Dominika, Braun Marcin, Kitowska Kamila, Mieczkowski Kamil, Kordek Radzislaw, Sadej Rafal, Romanska HannaAcademic press:Journal of Experimental & Clinical Cancer Research (rok: 2019, tom: 38, strony: 230), Wydawca: BMC Springer NatureStatus:PublishedDOI:10.1186/s13046-019-1236-6 - link to the publication
- Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells.Authors:Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, Skladanowski AC, Zaczek AJ, Biernat W, Kordek R, Romanska HM, Sadej RAcademic press:Oncotarget (rok: 2016, tom: 7, strony: 86011-86025), Wydawca: Impact Journals, LLCStatus:PublishedDOI:10.18632/oncotarget.13322 - link to the publication
- Hormonal Receptor Status Determines Prognostic Significance of FGFR2 in Invasive Breast Carcinoma.Authors:Braun, M.; Piasecka, D.; Tomasik, B.; Mieczkowski, K.; Stawiski, K.; Zielinska, A.; Kopczynski, J.; Nejc, D.; Kordek, R.; Sadej, R.; Romanska, H.M.Academic press:Cancers (rok: 2020, tom: 12, strony: 45309), Wydawca: MDPIStatus:PublishedDOI:10.3390/cancers12092713 - link to the publication