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Information of the project and the call

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Molekularne podstawy internalizacji przeciwciał skierowanych przeciwko receptorom czynnika wzrostu fibroblastów FGF

2015/16/S/NZ3/00363

Keywords:

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Opaliński 

Number of co-investigators in the project: 2

Call: FUGA 4 - announced on 2014-12-15

Amount awarded: 612 000 PLN

Project start date (Y-m-d): 2015-10-01

Project end date (Y-m-d): 2018-09-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding
    Authors:
    Opalinski L, Szczepara M, Sokolowska-Wedzina A, Zakrzewska M, Otlewski J.
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2017, tom: 89, strony: 193-198), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2017.06.015 - link to the publication
  2. Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity
    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska and Jacek Otlewski
    Academic press:
    Scientific Reports (rok: 2017, tom: 7(1), strony: 7121), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-07479-z - link to the publication
  3. FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1
    Authors:
    Swiderska KW, Szlachcic A, Opaliński Ł, Zakrzewska M, Otlewski J
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: E2098), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19072098 - link to the publication
  4. High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1
    Authors:
    Łukasz Opaliński, Jakub Szymczyk, Martyna Szczepara, Marika Kucińska, Daniel Krowarsch, Małgorzata Zakrzewska, Jacek Otlewski
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: E1435), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19051435 - link to the publication
  1. Requirements for the internalization of antibodies directed against FGFR1
    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Małgorzata Zakrzewska, Jacek Otlewski
    Conference:
    X Parnas Conference, Young Scientist Forum, "Molecules in the Living Cell and Innovative Medicine" (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 10.06.2016-12.06.2016
    Status:
    Published
    DOI:
    link to the publication
  2. Requirements for the internalization of antibodies directed against FGFR1
    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Małgorzata Zakrzewska, Jacek Otlewski
    Conference:
    2nd Congress Bio 2016 "Expanding beyond the limits" (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13.09.2016-16.09.2016
    Status:
    Published
    DOI:
    link to the publication

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