Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molekularne podstawy internalizacji przeciwciał skierowanych przeciwko receptorom czynnika wzrostu fibroblastów FGF

2015/16/S/NZ3/00363

Keywords:

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Łukasz Opaliński 

Number of co-investigators in the project: 2

Call: FUGA 4 - announced on 2014-12-15

Amount awarded: 612 000 PLN

Project start date (Y-m-d): 2015-10-01

Project end date (Y-m-d): 2018-09-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1
    Authors:
    Swiderska KW, Szlachcic A, Opaliński Ł, Zakrzewska M, Otlewski J
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: E2098), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19072098 - link to the publication
  2. High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1
    Authors:
    Łukasz Opaliński, Jakub Szymczyk, Martyna Szczepara, Marika Kucińska, Daniel Krowarsch, Małgorzata Zakrzewska, Jacek Otlewski
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: E1435), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19051435 - link to the publication
  3. Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity
    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska and Jacek Otlewski
    Academic press:
    Scientific Reports (rok: 2017, tom: 7(1), strony: 7121), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-07479-z - link to the publication
  4. The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding
    Authors:
    Opalinski L, Szczepara M, Sokolowska-Wedzina A, Zakrzewska M, Otlewski J.
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2017, tom: 89, strony: 193-198), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2017.06.015 - link to the publication
  1. Requirements for the internalization of antibodies directed against FGFR1
    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Małgorzata Zakrzewska, Jacek Otlewski
    Conference:
    2nd Congress Bio 2016 "Expanding beyond the limits" (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 13.09.2016-16.09.2016
    Status:
    Published
    DOI:
    link to the publication
  2. Requirements for the internalization of antibodies directed against FGFR1
    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Małgorzata Zakrzewska, Jacek Otlewski
    Conference:
    X Parnas Conference, Young Scientist Forum, "Molecules in the Living Cell and Innovative Medicine" (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 10.06.2016-12.06.2016
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy