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Molekularne podstawy internalizacji przeciwciał skierowanych przeciwko receptorom czynnika wzrostu fibroblastów FGF

2015/16/S/NZ3/00363

Descriptors

  • NZ3_1: Biologia komórki

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Wrocławski, Wydział Biotechnologii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Łukasz Opaliński

Number of co-investigators in the project: 2

Call

FUGA 4 – announced on 2014-12-15

Amount awarded
612 000 PLN
Project start date
2015-10-01
Project end date
2018-09-30
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (4)

  1. The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding

    Authors:
    Opalinski L, Szczepara M, Sokolowska-Wedzina A, Zakrzewska M, Otlewski J.
    Academic press:
    International Journal of Biochemistry and Cell Biology (year: 2017, volume: 89, pages: 193-198), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2017.06.015 – link to the publication

  2. Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Martyna Szczepara, Małgorzata Zakrzewska and Jacek Otlewski
    Academic press:
    Scientific Reports (year: 2017, volume: 7(1), pages: 7121), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-07479-z – link to the publication

  3. High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1

    Authors:
    Łukasz Opaliński, Jakub Szymczyk, Martyna Szczepara, Marika Kucińska, Daniel Krowarsch, Małgorzata Zakrzewska, Jacek Otlewski
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19, pages: E1435), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19051435 – link to the publication

  4. FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

    Authors:
    Swiderska KW, Szlachcic A, Opaliński Ł, Zakrzewska M, Otlewski J
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19, pages: E2098), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19072098 – link to the publication

Articles in post-conference publications (2)

  1. Requirements for the internalization of antibodies directed against FGFR1

    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Małgorzata Zakrzewska, Jacek Otlewski
    Conference:
    2nd Congress Bio 2016 Expanding beyond the limits (year: 2016, pages: 39), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 13.09.2016-16.09.2016
    Status:
    Published

  2. Requirements for the internalization of antibodies directed against FGFR1

    Authors:
    Łukasz Opaliński, Aleksandra Sokołowska-Wędzina, Małgorzata Zakrzewska, Jacek Otlewski
    Conference:
    X Parnas Conference, Young Scientist Forum, Molecules in the Living Cell and Innovative Medicine (year: 2016, pages: 24), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 10.06.2016-12.06.2016
    Status:
    Published

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