Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Effect of physical processes and excipients on properties of poorly water-soluble active pharmaceutical ingredients

2015/16/W/NZ7/00404

Keywords:

amorphous drugs water solubility molecular dynamics physical stability confined systems mixtures

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marian Paluch 

Number of co-investigators in the project: 16

Call: SYMFONIA 3 - announced on 2014-12-15

Amount awarded: 5 605 000 PLN

Project start date (Y-m-d): 2015-11-19

Project end date (Y-m-d): 2021-11-18

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Waga precyzyjna typu RadWag (2 621 PLN)
  2. Aparat do badania wielkości cząstek metodą dyfrakcji laserowej (390 000 PLN)
  3. Doposażenie reometru (298 000 PLN)
  4. Pompa sprężania wstępnego z dyskami bezpieczeństwa.
  5. Automatyczny kolektor frakcji do aparatu 1 wg. FP IX z zestawem do badania specyficznej szybkości rozpuszczania (260 000 PLN)
  6. Laptop (3 szt.) (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (48)
  • Articles in post-conference publications (26)
  • Book publications / chapters in book publications (3)
  1. Broadband-dielectric-spectroscopy study of molecular dynamics in a mixture of itraconazole and glycerol in glassy, smectic-A, and isotropic phases
    Authors:
    M. Rams-Baron, D. Kramarczyk, J. Knapik-Kowalczuk, B. Hachula, A. Kocot, M. Paluch
    Academic press:
    Physical Review E (rok: 2021, tom: 104, strony: 34702), Wydawca: AMERICAN PHYSICAL SOCIETY
    Status:
    Published
    DOI:
    10.1103/PhysRevE.104.034702 - link to the publication
  2. Changes in Physical Stability of Supercooled Etoricoxib after Compression
    Authors:
    Marzena Rams-Baron, Justyna Pacułt, Agnieszka Jędrzejowska, Justyna Knapik-Kowalczuk, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2018, tom: 15, strony: 3969−3978), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00428 - link to the publication
  3. E ff ects of cooling rate on structural relaxation in amorphous drugs: elastically collective nonlinear langevin equation theory and machine learning study
    Authors:
    Anh D. Phan, Katsunori Wakabayashi, Marian Paluch, Vu D. Lam
    Academic press:
    RSC Adv. (rok: 2019, tom: 9, strony: 40214), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9ra08441j - link to the publication
  4. Influence of Polymeric Additive on the Physical Stability and Viscoelastic Properties of Aripiprazole
    Authors:
    Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Karolina Jurkiewicz, Zaneta Wojnarowska, Mateusz Kurek, Renata Jachowicz, Marian Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2019, tom: 16, strony: 1742-1750), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.9b00084 - link to the publication
  5. Molecular Dynamics and Physical Stability of Ibuprofen in Binary Mixtures with an Acetylated Derivative of Maltose
    Authors:
    Katarzyna Grzybowska, Andrzej Grzybowski, Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Krzysztof Woyna-Orlewicz, Joanna Szafraniec-Szczęsny, Agata Antosik-Rogóż, Renata Jachowicz, Katarzyna Kowalska-Szojda, Piotr Lodowski, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2020, tom: 17, strony: 3087 − 3105), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.0c00517 - link to the publication
  6. Molecular dynamics, viscoelastic properties and physical stability studies of a new amorphous dihydropyridine derivative with T-type calcium channel blocking activity
    Authors:
    Justyna Knapik-Kowalczuk, Miyase Gözde Gündüz, Krzysztof Chmiel, Karolina Jurkiewicz, Mateusz Kurek, Lidia Tajber, Renata Jachowicz, Marian Paluch
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2020, tom: 141, strony: 105083), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2019.105083 - link to the publication
  7. Molecular relaxations in supercooled liquid and glassy states of amorphous gambogic acid: Dielectric spectroscopy, calorimetry, and theoretical approach
    Authors:
    Anh D. Phan, Tran Thi Thu Thuy, Nguyen Thi Kim An, Justyna Knapik-Kowalczuk, Marian Paluch, and Katsunori Wakabayashi
    Academic press:
    AIP Advances (rok: 2020, tom: 10, strony: 25128), Wydawca: AIP Publishing
    Status:
    Published
    DOI:
    10.1063/1.5139101 - link to the publication
  8. Can Storage Time Improve the Physical Stability of Amorphous Pharmaceuticals with Tautomerization Ability Exposed to Compression? The Case of a Chloramphenicol Drug
    Authors:
    Justyna Knapik-Kowalczuk, Zaneta Wojnarowska, Krzysztof Chmiel, Marzena Rams-Baron, Lidia Tajber, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2018, tom: 15, strony: 1928−1940), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00099 - link to the publication
  9. Compression-Induced Phase Transitions of Bicalutamide
    Authors:
    Szafraniec-Szczęsny J., Antosik-Rogóż A., Knapik-Kowalczuk J., Kurek M., Szefer E., Gawlak K., Chmiel K., Peralta S., Niwiński K., Pielichowski K., Paluch M., Jachowicz R.
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12, strony: 438), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12050438 - link to the publication
  10. Effect of Polymer Chain Length on the Physical Stability of Amorphous Drug − Polymer Blends at Ambient Pressure
    Authors:
    Justyna Pacułt, Marzena Rams-Baron, Beata Chrząszcz, Renata Jachowicz, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2018, tom: 15, strony: 2807−2815), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00312 - link to the publication
  11. Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate
    Authors:
    Pacławski A., Szlęk J., Jachowicz R., Giovagnoli S., WiśniowskaB., Polak S., Czub N., Mendyk A.
    Academic press:
    Appl. Sci. (rok: 2020, tom: 10, strony: 7109), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app10207109 - link to the publication
  12. High-Pressure Dielectric Studies - a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures
    Authors:
    Krzysztof Chmiel, Justyna Knapik-Kowalczuk, Ewa Kamińska, Lidia Tajber, Marian Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2021, tom: 18, strony: 3050 − 3062), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.1c00264 - link to the publication
  13. How can we improve the physical stability of co-amorphous system containing flutamide and bicalutamide? The case of ternary amorphous solid dispersions
    Authors:
    Justyna Pacult, Marzena Rams-Baron, Krzysztof Chmiel, Karolina Jurkiewicz, Agata Antosik, Joanna Szafraniec, Mateusz Kurek, Renata Jachowicz, Marian Paluch
    Academic press:
    Eur. J. Pharm. Sci. (rok: 2019, tom: 136, strony: 104947), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2019.06.001 - link to the publication
  14. How does the CO2 in Supercritical State Affect the Properties of Drug-Polymer Systems, Dissolution Performance and Characteristics of Tablets Containing Bicalutamide?
    Authors:
    Antosik-Rogóż A., Szafraniec-Szczęsny J., Chmiel K., Knapik-Kowalczyk J., Kurek M., Gawlak K., Danesi V. P., Paluch M., Jachowicz R.
    Academic press:
    MDPI Materials (rok: 2020, tom: 13, strony: 2848), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13122848 - link to the publication
  15. Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System
    Authors:
    Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Karolina Jurkiewicz, Natália T. Correia, Wiesław Sawicki, Marian Paluch
    Academic press:
    Pharmaceuticals (rok: 2019, tom: 12, strony: 40), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ph12010040 - link to the publication
  16. Planetary ball milling and supercritical fluid technology as a way to enhance dissolution of bicalutamide
    Authors:
    Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Mateusz Kurek, Karolina Syrek, Krzysztof Chmiel, Marian Paluch, Renata Jachowicz
    Academic press:
    Int. J. Pharm. (rok: 2017, tom: 533, strony: 470–479), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2017.03.078 - link to the publication
  17. Recent developments in the experimental investigations of relaxations in pharmaceuticals by dielectric techniques at ambient and elevated pressure
    Authors:
    Katarzyna Grzybowska, Simone Capaccioli, Marian Paluch
    Academic press:
    Advanced Drug Delivery Reviews (rok: 2016, tom: 100, strony: 158–182), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.addr.2015.12.008 - link to the publication
  18. Stabilization of the Amorphous Ezetimibe Drug by Confining Its Dimension
    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, K. Jurkiewicz, A. Stankiewicz, M. Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2016, tom: 13, strony: 1308−1316), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00903 - link to the publication
  19. Ternary Eutectic Ezetimibe - Simvastatin - Fenofibrate System and the Physical Stability of Its Amorphous Form
    Authors:
    Justyna Knapik-Kowalczuk, Daniel Kramarczyk, Karolina Jurkiewicz, Krzysztof Chmiel, Marian Paluch
    Academic press:
    Molecular Pharmaceutics (rok: 2021, tom: 18, strony: 3588 − 3600), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.1c00485 - link to the publication
  20. The indications of tautomeric conversion in amorphous bicalutamide drug
    Authors:
    Marzena Rams-Baron, Patryk Wlodarczyk, Mateusz Dulski, Agnieszka Wlodarczyk, Danuta Kruk, Adam Rachocki, Renata Jachowicz, Marian Paluch
    Academic press:
    Eur. J. Pharm. Sci. (rok: 2017, tom: 110, strony: 117-123), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2017.06.034 - link to the publication
  21. Theoretical Model for the Structural Relaxation Time in Coamorphous Drugs
    Authors:
    Anh D. Phan, Justyna Knapik-Kowalczuk, Marian Paluch, Trinh X. Hoang, Katsunori Wakabayashi
    Academic press:
    Mol. Pharmaceutics (rok: 2019, tom: 16, strony: 2992−2998), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.9b00230 - link to the publication
  22. COMPUTATIONAL INTELLIGENCE FOR PREDICTING BIOLOGICAL EFFECTS OF DRUG ABSORPTION IN LUNGS
    Authors:
    Adam Pacławski, Jakub Szlęk, Aleksander Mendyk
    Academic press:
    Computer Science (rok: 2019, tom: 20, strony: 99–121), Wydawca: AGH University of Science and Technology, Krakow, Poland
    Status:
    Published
    DOI:
    10.7494/csci.2019.20.1.2992 - link to the publication
  23. Current research trends in dielectric relaxation studies of amorphous pharmaceuticals: Physical stability, tautomerism, and the role of hydrogen bonding
    Authors:
    Justyna Knapik-Kowalczuk, Marzena Rams-Baron, Marian Paluch
    Academic press:
    Trends in Analytical Chemistry (rok: 2021, tom: 134, strony: 116097), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.trac.2020.116097 - link to the publication
  24. Enhanced dissolution of solid dispersions containing bicalutamide subjected to mechanical stress
    Authors:
    Szafraniec J., Antosik A., Knapik-Kowalczuk J., Chmiel K., Kurek M., Gawlak K., Paluch M., Jachowicz R.
    Academic press:
    Int. J. Pharm. (rok: 2018, tom: 542, strony: 18-26), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2018.02.040 - link to the publication
  25. Glass Transition Dynamics and Physical Stability of Amorphous Griseofulvin in Binary Mixtures with Low‑Tg Excipients
    Authors:
    Wenkang Tu, Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2019, tom: 16, strony: 3626−3635), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.9b00476 - link to the publication
  26. Green Synthesis of Lidocaine Ionic Liquids and Salts: Mechanisms of Formation and Interactions in the Crystalline and Supercooled States
    Authors:
    Julija Zotova, Zaneta Wojnarowska, Brendan Twamley, Marian Paluch, Lidia Tajber
    Academic press:
    ACS Sustainable Chem. Eng. (rok: 2020, tom: 8, strony: 18266 - 18276), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acssuschemeng.0c06811 - link to the publication
  27. Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals— The Case of Simvastatin
    Authors:
    Justyna Knapik-Kowalczuk, Daniel Kramarczyk, Krzysztof Chmiel, Jana Romanova, Kohsaku Kawakami, Marian Paluch
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12, strony: 384), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12040384 - link to the publication
  28. Isochronal Conditions  The Key To Maintain the Given Solubility Limit, of a Small Molecule within the Polymer Matrix, at Elevated Pressure
    Authors:
    Krzysztof Chmiel, Justyna Knapik-Kowalczuk, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2020, tom: 17, strony: 3730 - 3739), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.0c00463 - link to the publication
  29. Molecular Factors Governing the Liquid and Glassy States Recrystallization of Celecoxib in Binary Mixtures with Excipients of Di ff erent Molecular Weights
    Authors:
    K. Grzybowska, K. Chmiel, J. Knapik-Kowalczuk, A. Grzybowski, K. Jurkiewicz, and M. Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2017, tom: 14, strony: 1154−1168), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.6b01056 - link to the publication
  30. The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods
    Authors:
    Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Mateusz Kurek, Karolina Gawlak, Joanna Odrobińska, Marian Paluch, Renata Jachowicz
    Academic press:
    Pharmaceutics (rok: 2019, tom: 11, strony: 130), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/pharmaceutics11030130 - link to the publication
  31. The effect of molecular architecture on the physical properties of supercooled liquids studied by MD simulations: Density scaling and its relation to the equation of state
    Authors:
    K. Koperwas, A. Grzybowski, and M. Paluch
    Academic press:
    J. Chem. Phys. (rok: 2019, tom: 150, strony: 14501), Wydawca: AIP Publishing
    Status:
    Published
    DOI:
    10.1063/1.5050330 - link to the publication
  32. 3D printed orodispersible films with Aripiprazole
    Authors:
    Witold Jamróz, Mateusz Kurek, Ewelina Łyszczarz, Joanna Szafraniec, Justyna Knapik-Kowalczuk, Karolina Syrek, Marian Paluch, Renata Jachowicz
    Academic press:
    Int. J. Pharm. (rok: 2017, tom: 533, strony: 413–420), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2017.05.052 - link to the publication
  33. 3D printing of tablets containing amorphous aripiprazole by filaments co-extrusion
    Authors:
    Jamróz W., Kurek M, Czech A., Szafraniec J, Gawlak K, Jachowicz R.
    Academic press:
    Eur. J. Pharm. Biopharm. (rok: 2018, tom: 131, strony: 44-47), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2018.07.017 - link to the publication
  34. A New Method To Identify Physically Stable Concentration of Amorphous Solid Dispersions (I): Case of Flutamide + Kollidon VA64
    Authors:
    K. Chmiel, J. Knapik-Kowalczuk, K. Jurkiewicz, W. Sawicki, R. Jachowicz, and M. Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2017, tom: 14, strony: 3370−3380), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.7b00382 - link to the publication
  35. Atorvastatin as a Promising Crystallization Inhibitor of Amorphous Probucol: Dielectric Studies at Ambient and Elevated Pressure
    Authors:
    J. Knapik-Kowalczuk, Z. Wojnarowska, M. Rams-Baron, K. Jurkiewicz, J. Cielecka-Piontek, K. L. Ngai, and M. Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2017, tom: 14, strony: 2670−2680), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.7b00152 - link to the publication
  36. Co-Stabilization of Amorphous Pharmaceuticals - The Case of Nifedipine and Nimodipine
    Authors:
    Justyna Knapik-Kowalczuk, Wenkang Tu, Krzysztof Chmiel, Marzena Rams-Baron, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2018, tom: 15, strony: 2455−2465), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.8b00308 - link to the publication
  37. Data-driven modeling of the bicalutamide dissolution from powder systems
    Authors:
    Mendyk A. Pacławski A., Szafraniec-Szczęsny J., Antosik A., Jamróz W., Paluch M., Jachowicz R.
    Academic press:
    AAPS Pharm. Sci. Tech. (rok: 2020, tom: 21, strony: 111), Wydawca: AAPS
    Status:
    Published
    DOI:
    10.1208/s12249-020-01660-w - link to the publication
  38. Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound
    Authors:
    Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Justyna Pacułt, Klaudia Bialek, Lidia Tajber, Marian Paluch
    Academic press:
    Pharmaceutics (rok: 2020, tom: 12, strony: 460), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12050460 - link to the publication
  39. Glass formability in medium-sized molecular systems/pharmaceuticals. I. Thermodynamics vs. kinetics
    Authors:
    Wenkang Tu, Xiangqian Li, Zeming Chen, Ying Dan Liu, Massimiliano Labardi, Simone Capaccioli, M. Paluch, Li-Min Wang
    Academic press:
    J. Chem. Phys. (rok: 2016, tom: 144, strony: 174502-1 - 174502-12), Wydawca: AIP Publishing
    Status:
    Published
    DOI:
    10.1063/1.4947476 - link to the publication
  40. How does the high pressure affects the solubility of the drug within the polymer matrix in solid dispersion systems
    Authors:
    K. Chmiel, J. Knapik-Kowalczuk, M. Paluch
    Academic press:
    Eur. J. Pharm. Biopharm. (rok: 2019, tom: 143, strony: 45521), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2019.08.003 - link to the publication
  41. Molecular Dynamics, Recrystallization Behavior, and Water Solubility of the Amorphous Anticancer Agent Bicalutamide and Its Polyvinylpyrrolidone Mixtures
    Authors:
    Justyna Szczurek, Marzena Rams-Baron, Justyna Knapik-Kowalczuk, Agata Antosik, Joanna Szafraniec, Witold Jamróz, Mateusz Dulski, Renata Jachowicz, and Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2017, tom: 14, strony: 1071−1081), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.6b01007 - link to the publication
  42. Molecular disorder of Bicalutamide-Amorphous Solid Dispersions Obtained by Solvent Methods
    Authors:
    Szafraniec J., Antosik A., Knapik-Kowalczuk J., Gawlak K., Kurek M., Szlęk K., Paluch M., Jachowicz R.
    Academic press:
    Molecular disorder of Bicalutamide-Amorphous Solid Dispersions Obtained by Solvent Methods (rok: 2018, tom: 10, strony: 194-1 - 194-16), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics10040194 - link to the publication
  43. Amorphous Protic Ionic Systems as Promising Active Pharmaceutical Ingredients: The Case of the Sumatriptan Succinate Drug
    Authors:
    Z. Wojnarowska, J. Knapik, M. Rams-Baron, A. Jedrzejowska, M. Paczkowska, A. Krause, J. Cielecka-Piontek, M. Jaworska, P. Lodowski, M. Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2016, tom: 13, strony: 1111−1122), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5b00911 - link to the publication
  44. Broadband dielectric spectroscopy as an experimental alternative to calorimetric determination of the solubility of drugs into polymer matrix: Case of flutamide and various polymeric matrixes
    Authors:
    K. Chmiel, J. Knapik-Kowalczuk, R. Jachowicz, M. Paluch
    Academic press:
    Eur. J. Pharm. Biopharm. (rok: 2019, tom: 136, strony: 231-239), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2019.01.025 - link to the publication
  45. How Does the Addition of Kollidon®VA64 Inhibit the Recrystallization and Improve Ezetimibe Dissolution from Amorphous Solid Dispersions?
    Authors:
    Joanna Szafraniec-Szczęsny, Agata Antosik-Rogóż, Mateusz Kurek, Karolina Gawlak, Anna Górska, Sebastian Peralta, Justyna Knapik-Kowalczuk, Daniel Kramarczyk, Marian Paluch, Renata Jachowicz
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 147), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13020147 - link to the publication
  46. How can we improve the physical stability of co-amorphous system containing flutamide and bicalutamide? The case of ternary amorphous solid dispersions.
    Authors:
    Justyna Pacułt, Marzena Rams-Baron, Krzysztof Chmiel, Karolina Jurkiewicz, Agata Antosik, Joanna Szafraniec, Mateusz Kurek, Renata Jachowicz, Marian Paluch
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2021, tom: 159, strony: 105697), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejps.2020.105696 - link to the publication
  47. Molecular Dynamics and Physical Stability of Amorphous Nimesulide Drug and Its Binary Drug − Polymer Systems
    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, L. Tajber, H. Mesallati, K. J. Paluch, M. Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2016, tom: 13, strony: 1937−1946), Wydawca: AMERICAN CHEMICAL SOCIETY
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.6b00115 - link to the publication
  48. Tabletting solid dispersions of bicalutamide prepared using ball-milling or supercritical carbon dioxide: the interrelationship between phase transition and in-vitro dissolution
    Authors:
    Antosik-Rogóż A., Szafraniec-Szczęsny J., Gawlak K., Knapik-Kowalczyk J., Paluch M., Jachowicz R.
    Academic press:
    Pharmaceutical Development and Technology (rok: 2020, tom: 25, strony: 1109-1117), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10837450.2020.1797787 - link to the publication
  1. Heuristic modeling of bicalutamide dissolution
    Authors:
    Adam Pacławski, Aleksander Mendyk, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (rok: 2017, ), Wydawca: International Association for Pharmaceutical Technology, Kurfuerstenstraße 59, 55118 Mainz, Germany
    Data:
    konferencja 3-4.04
    Status:
    Published
  2. Milling-induced Amorphization of Bicalutamide
    Authors:
    Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Marian Paluch, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (rok: 2017, ), Wydawca: International Association for Pharmaceutical Technology, Kurfuerstenstraße 59, 55118 Mainz, Germany
    Data:
    konferencja 3-4.04
    Status:
    Published
  3. Physically stable amorphous APIs – are thay ready for extrusion?
    Authors:
    Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Karolina Jurkiewicz, Renata Jachowicz, Marian Paluch
    Conference:
    8th International Association of Physical Chemists Meeting (8th World Conference on Physico-Chemical Methods in Drug Discovery & 5th World Conference on ADMET and DMPK), September 9 - 11, 2019, Split, Croatia (rok: 2019, ), Wydawca: International Association of Physical Chemists
    Data:
    konferencja 09.09.2019-11.09.2019
    Status:
    Published
  4. Amorphous solid dispersions of celecoxib with large and small molecular weight crystallization inhibitors: The role of physicochemical factors in determining the physical stability
    Authors:
    K. Grzybowska, K. Chmiel, J. Knapik, M. Paluch
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2016, ), Wydawca: ResearchPharm(R) International Exhibition for R&D
    Data:
    konferencja 04.04.2016-07.04.2016
    Status:
    Published
  5. Changes in physical stability of supercooled etoricoxib after compression
    Authors:
    M. Rams-Baron, J. Pacułt, A. Jędrzejowska, J. Knapik-Kowalczuk, M. Paluch
    Conference:
    The 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals (rok: 2018, ), Wydawca: Wydawnictwo Uniwersytetu Śląskiego
    Data:
    konferencja 09.09.2018-11.09.2018
    Status:
    Published
  6. Enhanced Dissolution of Bicalutamide Processed with Macrogol 6000 by Supercritical CO2
    Authors:
    Agata Antosik, Joanna Szafraniec, Justyna Knapik-Kowalczuk, Marian Paluch, Renata Jachowicz
    Conference:
    2nd European Conference on Pharmaceutics (rok: 2017, ), Wydawca: International Association for Pharmaceutical Technology, Kurfuerstenstraße 59, 55118 Mainz, Germany
    Data:
    konferencja 3-4.04
    Status:
    Published
  7. Improved dissolution of bicalutamide subjected to mechanical treatment
    Authors:
    Szafraniec J. Antosik A., Knapik-Kowalczuk J., Paluch M., Jachowicz R.
    Conference:
    9th Polish-German Symposium on Pharmaceutical Science (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27.05
    Status:
    Published
  8. Porous silicate Syloid(R) 244 FP as carrier for amorphization of bicalutamide by using planetary-ball mill
    Authors:
    A. Antosik, J. Knapik, W. Jamróz, M. Paluch, R. Jachowicz
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2016, ), Wydawca: ResearchPharm(R) International Exhibition for R&D
    Data:
    konferencja 04.04.2016-07.04.2016
    Status:
    Published
  9. Aspekty technologiczne wytwarzania filamentów polimerowych z aripirazolem metodą ekstruzji topliwej
    Authors:
    M. Kurek, D. Świerzowska, W. Jamróz, K. Niwiński, R. Jachowicz
    Conference:
    XXIII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Data:
    konferencja 19-22.09
    Status:
    Published
  10. Broadband dielectric spectroscopy as a tool for determining solubility limits: case of flutamide-based ASDs
    Authors:
    K. Chmiel, J. Knapik-Kowalczuk, M. Paluch
    Conference:
    The 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals (rok: 2018, ), Wydawca: Wydawnictwo Uniwersytetu Śląskiego
    Data:
    konferencja 09.09.2018-11.09.2018
    Status:
    Published
  11. Empirical model for prediction of bicalutamide dissolution
    Authors:
    Pacławski A., Mendyk A., Antosik A., Szafraniec J., Jachowicz R.
    Conference:
    9th Polish-German Symposium on Pharmaceutical Science (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27.05
    Status:
    Published
  12. How compression affect the physical stability of amorphous pharmaceuticals
    Authors:
    Marian Paluch, Justyna Knapik-Kowalczuk, Marzena Rams-Baron, Krzysztof Chmiel, Karolina Jurkiewicz
    Conference:
    8th International Association of Physical Chemists Meeting (8th World Conference on Physico-Chemical Methods in Drug Discovery & 5th World Conference on ADMET and DMPK), September 9 - 11, 2019, Split, Croatia (rok: 2019, ), Wydawca: International Association of Physical Chemists
    Data:
    konferencja 09.09.2019-11.09.2019
    Status:
    Published
  13. Let's make a mess… Amorphization of Ezetimibe as a Way of Dissolution Enhancement
    Authors:
    Joanna Szafraniec, Sebastian Peralta, Agata Antosik, Karolina Gawlak, Justyna Knapik-Kowalczuk, Marian Paluch, Renata Jachowicz
    Conference:
    The 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals (rok: 2018, ), Wydawca: Wydawnictwo Uniwersytetu Śląskiego
    Data:
    konferencja 09.09.2018-11.09.2018
    Status:
    Published
  14. The role of molecular dynamics in predicting the physical stability of amorphous pharmaceuticals
    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, L. Hawelek, M. Paluch
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2016, ), Wydawca: ResearchPharm(R) International Exhibition for R&D
    Data:
    konferencja 04.04.2016-07.04.2016
    Status:
    Published
  15. Aripiprazole dissolution improvement based on various technological processes
    Authors:
    Mateusz Kurek, Witold Jamróz, Joanna Szafraniec, Justyna Knapik-Kowalczuk, Marian Paluch, Renata Jachowicz
    Conference:
    The 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals (rok: 2018, ), Wydawca: Wydawnictwo Uniwersytetu Śląskiego
    Data:
    konferencja 09.09.2018-11.09.2018
    Status:
    Published
  16. Czy amorfizacja gwarantuje poprawę rozpuszczalności substancji leczniczych?
    Authors:
    Joanna Szafraniec, Agata Antosik, Krzysztof Woyna-Orlewicz, Karolina Gawlak, Justyna Knapik-Kowalczuk, Marian Paluch, Renata Jachowicz
    Conference:
    XXIII Naukowy Zjazd Polskiego Towarzystwa Farmaceutycznego (rok: 2017, ), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Data:
    konferencja 19-22.09
    Status:
    Published
  17. Dissolution rate improvement of aripiprazole using high Energy ball milling
    Authors:
    Kurek M., Jamróz W., Szafraniec J., Syrek K., Paluch M., Jachowicz R.
    Conference:
    11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2018, ), Wydawca: ResearchPharm(R) International Exhibition for R&D
    Data:
    konferencja 19.03.2018-22.03.2018
    Status:
    Published
  18. Enhanced solubility of mechanically activated bicalutamide
    Authors:
    J. Szafraniec, A. Antosik, J. Knapik, M. Paluch, R. Jachowicz
    Conference:
    11th Central European Symposium on Pharmaceutical Technology (rok: 2016, ), Wydawca: Pharmaceutical Association of Serbia
    Data:
    konferencja 22.09.2016-24.09.2016
    Status:
    Published
  19. Tablets containing bicalutamide proceed with hydrophilic carriers - macrogol 6000 or poloxamer 407
    Authors:
    Antosik A., Szafraniec J., Knapik-Kowalczuk J., Szczurek J., Paluch M., Jachowicz R.
    Conference:
    9th Polish-German Symposium on Pharmaceutical Science (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27.05
    Status:
    Published
  20. The perspective of applying binary co-amorphous system with Bicalutamide and Flutamide
    Authors:
    Justyna Pacułt, Marzena Rams-Baron, Krzysztof Chmiel, Karolina Jurkiewicz, Agata Antosik, Joanna Szafraniec, Renata Jachowicz, Marian Paluch
    Conference:
    The 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals (rok: 2018, ), Wydawca: Wydawnictwo Uniwersytetu Śląskiego
    Data:
    konferencja 09.09.2018-11.09.2018
    Status:
    Published
  21. Effect of tableting on phase transition and dissolution of anticancer drug – bicalutamide co-milled with PVP
    Authors:
    Szafraniec J., Antosik A., Gawlak K., Knapik-Kowalczuk J., Paluch M., Jachowicz R.
    Conference:
    11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2018, ), Wydawca: ResearchPharm(R) International Exhibition for R&D
    Data:
    konferencja 19.03.2018-22.03.2018
    Status:
    Published
  22. Emerging ways in suppression of re-crystallization of amorphous anti-cholesterol agents
    Authors:
    J. Knapik, Z. Wojnarowska, K. Grzybowska, K. Jurkiewicz and M. Paluch
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (rok: 2016, ), Wydawca: ResearchPharm(R) International Exhibition for R&D
    Data:
    konferencja 04.04.2016-07.04.2016
    Status:
    Published
  23. High-pressure drug-polymer solubility studies utilizing broadband dielectric spectroscopy
    Authors:
    Krzysztof Chmiel, Justyna Knapik-Kowalczuk, Marian Paluch
    Conference:
    8th International Association of Physical Chemists Meeting (8th World Conference on Physico-Chemical Methods in Drug Discovery & 5th World Conference on ADMET and DMPK), September 9 - 11, 2019, Split, Croatia (rok: 2019, ), Wydawca: International Association of Physical Chemists
    Data:
    konferencja 09.09.2019-11.09.2019
    Status:
    Published
  24. Molecular dynamics, physical stability and water solubility of ibuprofen in binary mixtures with octaacetyl-maltose
    Authors:
    K. Grzybowska, J. Knapik-Kowalczuk, A. Grzybowski, K. Chmiel, K. Woyna-Orlewicz, M. Paluch
    Conference:
    The 1st International Conference on Contemporary Pharmacy Challenges: Amorphous Pharmaceuticals and Biopharmaceuticals (rok: 2018, ), Wydawca: Wydawnictwo Uniwersytetu Śląskiego
    Data:
    konferencja 09.09.2018-11.09.2018
    Status:
    Published
  25. The dissolution rate enhancement of bicalutamide by using silica-based carriers
    Authors:
    Szafraniec J., Antosik A., Knapik-Kowalczuk J., Paluch M., Jachowicz R.
    Conference:
    9th Polish-German Symposium on Pharmaceutical Science (rok: 2017, ), Wydawca: Jagiellonian University Medical College, Polish Academy of Science, Polish Pharmaceutical Society
    Data:
    konferencja 26-27.05
    Status:
    Published
  26. The effect of Ball Milling and Spray Drying on Phase Transition, Particle size Reduction and Dissolution of Bicalutamide
    Authors:
    Szafraniec J., Antosik A., Gawlak K., Knapik-Kowalczuk J., Paluch M., Jachowicz R
    Conference:
    12th Central European Symposium on Pharmaceutical Technology and Regulatory Affairs and Satellite Symposium on Pharmaceutical Biotechnology (rok: 2018, ), Wydawca: Hungarian Society for Pharmaceutical Sciences
    Data:
    konferencja 20.09.2018-22.09.2018
    Status:
    Published
  1. Crystallization of Amorphous Pharmaceuticals at Ambient and Elevated Pressure Conditions
    Authors:
    Justyna Knapik-Kowalczuk, Krzysztof Chmiel, Marian Paluch
    Book:
    Crystallization as Studied by Broadband Dielectric Spectroscopy (rok: 2020, tom: nie dotyczy, strony: 55-87), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
  2. Application of Broadband Dielectric Spectroscopy to Study Molecular Mobility in Pharmaceutical Systems
    Authors:
    Katarzyna Grzybowska, Karolina Adrjanowicz, Marian Paluch
    Book:
    Disordered Pharmaceutical Materials (rok: 2016, tom: nie dotyczy, strony: 301-359), Wydawca: Wiley-VCH
    Status:
    Published
  3. Wszystkie rozdziały
    Authors:
    Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
    Book:
    Amorphous Drugs: Benefits and Challenges (rok: 2018, tom: nie dotyczy, strony: 1-230), Wydawca: Springer International Publishing AG
    Status:
    Published

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