Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Composites of nucleic acids and oligofunctionalized boron clusters as new material for bionanotechnology

2015/16/W/ST5/00413

Keywords:

nanotechnology DNA architecture boron clusters biosensors medical diagnostics

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_9: Biomaterials, biocompatible materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Biologii Medycznej PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zbigniew Leśnikowski 

Number of co-investigators in the project: 9

Call: SYMFONIA 3 - announced on 2014-12-15

Amount awarded: 3 430 080 PLN

Project start date (Y-m-d): 2015-11-16

Project end date (Y-m-d): 2022-11-15

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System wyparki obrotowej z wyposażeniem (2 szt.) (70 000 PLN)
  2. Wirówka próżniowa typu "Speedvac" (55 000 PLN)
  3. Spektrofotometr przenośny w kropli (39 800 PLN)
  4. Pompa hybrydowa (25 000 PLN)
  5. Reaktor mikrofalowy.
  6. Agregat chłodzący (2 szt.) (33 200 PLN)
  7. DNA/RNA Syntetyzer (180 000 PLN)
  8. Liofilizator (75 000 PLN)
  9. System do chromatografii kartridżowej (270 000 PLN)
  10. Wytrząsarka o ruchu koziołkującym, wielofuncyjna. (32 000 PLN)

Information in the final report

  • Publication in academic press/journals (17)
  • Articles in post-conference publications (37)
  • Book publications / chapters in book publications (1)
  1. Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2'-deoxyuridine boron cluster conjugate
    Authors:
    Dijana Saftić, Mirosława Studzińska, Edyta Paradowska, Ivo Piantanida, Goran Baranović, Magdalena Białek-Pietras and Zbigniew J. Leśnikowski
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 94, strony: 103466), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.103466 - link to the publication
  2. High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Milena Sobczak, BłazejWojtczak, Sławomir Janczak, Zbigniew J. Lesnikowski, Barbara Nawrot
    Academic press:
    Molecules (rok: 2017, tom: 22, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22091393 - link to the publication
  3. EGFR-targeted cellular delivery of therapeutic nucleic acids mediated by boron clusters
    Authors:
    Kaniowski D., Suwara J., Ebenryter-Olbińska K., Jakóbik-Kolon A., Nawrot B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 14793), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232314793 - link to the publication
  4. Recent developments with boron as a platform for novel drug design
    Authors:
    Zbigniew J. Leśnikowski
    Academic press:
    Expert Opinion on Drug Discovery (rok: 2016, tom: 11, strony: 569–578), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17460441.2016.1174687 - link to the publication
  5. Insights into molecular structure of adenosine-boron cluster conjugates and theirs phenyl isosters as adenosine receptor ligands: Nuclear magnetic resonance, crystallographic and computational studies
    Authors:
    Daniel Baranowski, Adam Mieczkowski, Damian Trzybiński, Krzysztof Woźniak, Katarzyna Bednarska-Szczepaniak, Zofia Gdaniec, Zbigniew J. Leśnikowski
    Academic press:
    Journal of Molecular Structure (rok: 2023, tom: 1274, strony: 134588), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2022.134588 - link to the publication
  6. Boron clusters as enhancers of RNase H activity in the smart strategy of gene silencing by antisense oligonucleotides
    Authors:
    Kaniowski D., Kulik K., Suwara J., Ebenryter-Olbińska K., Nawrot B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 12190), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232012190 - link to the publication
  7. Carborane- or Metallacarborane-Linked Nucleotides for Redox Labeling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing
    Authors:
    David Kodr, Cansu Pinar Yenice, Anna Simonova, Dijana Pavlović-Saftic, Radek Pohl, ́Veronika Sykorová, Mayreli Ortiz, Ludek Havran, Miroslav Fojta, Zbigniew J. Lesnikowski, Ciara K. O'Sullivan, Michal Hocek
    Academic press:
    Journal of American Chemical Society (rok: 2021, tom: 143, strony: 7124-7134), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.1c02222 - link to the publication
  8. Versatile Method for the Site-Specific Modification of DNA with Boron Clusters: Anti-Epidermal Growth Factor Receptor (EGFR) Antisense Oligonucleotide Case
    Authors:
    Katarzyna Ebenryter-Olbinska, Damian Kaniowski, Milena Sobczak, Błazej A. Wojtczak, Sławomir Janczak, Ewelina Wielgus, Barbara Nawrot, Zbigniew J. Lesnikowski
    Academic press:
    Chemistry A European Journal (rok: 2017, tom: 23, strony: 16535 – 16546), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.201702957 - link to the publication
  9. Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism
    Authors:
    Edyta Paradowska, Mirosława Studzinska, Agnieszka Jabłonska, Valeri Lozovski, Natalia Rusinchuk, Iuliia Mukha, Nadiia Vitiuk, Zbigniew J. Lesnikowski
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 5960), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26195960 - link to the publication
  10. Boron Clusters as a Platform for New Materials: Composites of Nucleic Acids and Oligofunctionalized Carboranes (C2B10H12) and their Assembly into Functional Nanoparticles
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Slawomir Janczak, Anna Maciaszek, Katarzyna Bednarska, Barbara Nawrot and Zbigniew Lesnikowski
    Academic press:
    Nanoscale (rok: 2020, tom: 12, strony: 103-114), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9NR06550D - link to the publication
  11. Composites of Nucleic Acids and Boron Clusters (C2B10H12) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew Lesnikowski, Barbara Nawrot
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4863), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094863 - link to the publication
  12. DNA Modified with Boron–Metal Cluster Complexes [M(C2B9H11)2]—Synthesis, Properties, and Applications
    Authors:
    Agnieszka B. Olejniczak, Barbara Nawrot and Zbigniew J. Lesnikowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19113501 - link to the publication
  13. Intramolecular rotations and electronic states of iron in the iron bis(dicarbollide) complex Fe[(C2B9H11)2] studied by a 57Fe nuclear probe and computational methods.
    Authors:
    Katarzyna Bednarska-Szczepaniak, Katarzyna Dziedzic-Kocurek, Ewelina Przelazły, Jan Stanek and Zbigniew J. Leśnikowski
    Academic press:
    Chemical Communications (rok: 2022, tom: 58, strony: 391-394), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1CC05111C - link to the publication
  14. Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase
    Authors:
    Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus, Zbigniew Leśnikowski and Barbara Nawrot
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10050718 - link to the publication
  15. Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives
    Authors:
    Dijana Saftić, Biserka Žinić, Ljubica Glavaš-Obrovac, Mirosława Studzińska, Edyta Paradowska & Zbigniew J. Leśnikowski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (rok: 2018, tom: 37, strony: 397-414), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2018.1485932 - link to the publication
  16. Unusual resistance of cobalt bis dicarbollide phosphate and phosphorothioate bridged esters towards alkaline hydrolysis: The "metallacarborane effect
    Authors:
    Carla Sardo, Sławomir Janczak and Zbigniew J. Leśniowski
    Academic press:
    Journal of Organometallic Chemistry (rok: 2019, tom: 896, strony: 70-76), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jorganchem.2019.06.001 - link to the publication
  17. What are the current challenges with the application of boron clusters to drug design?
    Authors:
    Zbigniew J. Leśnikowski
    Academic press:
    Expert Opinion on Drug Discovery (rok: 2020, tom: 15, strony: 45294), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17460441.2021.1867531 - link to the publication
  1. Antiviral effect of non-functionalized gold nanoparticles against herpes simplex virus type 1 (HSV-1)
    Authors:
    Leśnikowski Z., Paradowska E., Studzińska M., Lozovski V., Rusinchuk N., Mukha Iu., Vityuk N.
    Conference:
    Nanotechnology and Nanomaterials (NANO-2018) (rok: 2018, ), Wydawca: National Academy of Sciences of Ukraine
    Data:
    konferencja 27-30 August
    Status:
    Published
  2. BORON CLUSTERS – FROM NANOMACHINES TO DNA-NANOCONSTRUCTION
    Authors:
    Zbigniew J. Lesnikowski
    Conference:
    NANOTECH POLAND 2016 Conference and Exhibition (rok: 2016, ), Wydawca: Centrum NanoBioMedyczne Uniwersytetu im . Adama Mickiewicza w Poznaniu
    Data:
    konferencja 22-25 czerwca
    Status:
    Published
  3. Comparative study of inorganic (boron cluster) and organic (phenyl) adenosine modifications as adenosine receptors ligands: Synthesis, in silico docking and physicochemical and biological evaluation
    Authors:
    Aleksandra Kierozalska, Adam Mieczkowski, Dijana Saftić, Katarzyna Bednarska, Tomasz Przygodzki, Kamil Karolczak, Cezary Watała, Magdalena Białek-Pietras, Tomasz M. Goszczyński, Mirosława Studzińska, Edyta Paradowska, Harsha Rao, Zhan-Guo Gao, Kenneth A. Jacobson and Zbigniew J. Leśnikowski
    Conference:
    8th European Conference on Boron Chemistry (EUROBORON 8) (rok: 2019, ), Wydawca: Universite de Montpellier
    Data:
    konferencja 24-28 June 2019, Montpellier
    Status:
    Published
  4. Composites of DNA and boron clusters and their assembly into functional nanoparticles
    Authors:
    Katarzyna Ebenryter-Olbińska, Krzysztof Śmiałkowski, Carla Sardo, Damian Kaniowski, Gabriela Gajek, Katarzyna Bednarska-Szczepaniak, Lidia Żukowska, Barbara Nawrot and Zbigniew J. Leśnikowski
    Conference:
    9th European Conference on Boron Chemistry (rok: 2022, ), Wydawca: ICMAB and CSIC
    Data:
    konferencja 3-7 lipca
    Status:
    Published
  5. Composites of nucleic acids with oligofunctionalized carboranes (C2B10H12) as functional nanoparticles for downregulation of EGFR in cancer cells and carriers of boron for BNCT
    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, K. Kulik, A. Maciaszek, Agata Jakóbik-Kolon, Z.J. Leśnikowski and B. Nawrot
    Conference:
    Cold Spring Harbour Laboratory (rok: 2021, ), Wydawca: Cold Spring Harbour Laboratory
    Data:
    konferencja 2021-03-24-26
    Status:
    Published
  6. New conjugates of DNA-boron clusters with two faces
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Anna Maciaszek, Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew J. Leśnikowski and Barbara Nawrot
    Conference:
    IS3NA-IRT Virtual Virtual Symposium Symposium (rok: 2021, ), Wydawca: International Society of Nucleosides, Nucleotides and Nucleic Acids
    Data:
    konferencja 2021-08-26-27
    Status:
    Published
  7. Synthesis and physicochemical modification of antisense oligonucleotides modified with boron clusters
    Authors:
    K. Ebenryter-Olbińska, M. Sobczak, D. Kaniowski, ZJ. Leśnikowski, B. Nawrot
    Conference:
    XVIIth Symposium on Chemistry of Nucleic Acid Components (rok: 2017, ), Wydawca: UOCHB AV CR
    Data:
    konferencja June 4-9
    Status:
    Published
  8. Synthesis, physicochemical and biological properties of DNA oligonucleotides modified with boron clusters
    Authors:
    Katarzyna Ebenryter-Olbińska, Damian Kaniowski, Zbigniew Leśnikowski, Barbara Nawrot
    Conference:
    XIX International Symposium Advances in the Chemistry of Heteroorganic Compounds (rok: 2016, ), Wydawca: Polskie Towarzystwo Chemiczne
    Data:
    konferencja 25 listopada
    Status:
    Published
  9. Unusual chirality of metallacarboranes containing phosphorothioate bridging moiety
    Authors:
    Krzysztof Śmiałkowski, Carla Sardo, Zbigniew Leśnikowski
    Conference:
    23 International Conference on Phosphorus Chemistry (rok: 2021, ), Wydawca: AJD
    Data:
    konferencja 2021-07-5-9
    Status:
    Published
  10. Development of a dual fluorescence assay for monitoring of anti-EGFR silencing activity of chemically modified oligonucleotides; construction of pGFP-EGFR fusion plasmid
    Authors:
    D. Kaniowski, B. Nawrot
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2016, ), Wydawca: Uniwersytet im. Adama Mickiewicza
    Data:
    konferencja 19-23 września
    Status:
    Published
  11. Effect of boron cluster substitution on electronic properties of purine chromophore in adenosine nucleosides
    Authors:
    Aleksandra Kierozalska, Carla Sardo, Zbigniew J. Lenikowski
    Conference:
    XXI International Symposium "Advances in the Chemistry of Heteroorganic Compounds (rok: 2018, ), Wydawca: CBMM PAN, PTCh
    Data:
    konferencja 45619
    Status:
    Published
  12. Functionalization of metallacarboranes – Synthesis of cobalt bis dicarbollide cyclic phosphorothioate ester and its alkylation
    Authors:
    Carla Sardo, Róża Hamera-Fałdyga, Krzysztof Śmiałkowski, Zbigniew Leśnikowski
    Conference:
    XXII International Symposium Advances in the Chemistry of Heteroorganic Compounds (rok: 2019, ), Wydawca: CBMiM PAN, PTCh
    Data:
    konferencja 22 listopada
    Status:
    Published
  13. Highly boron-loaded antisense oligonucleotides conjugated with target-directed ligands for dual anticancer therapy: anti-EGFR and BNCT
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Justyna Suwara, Agata Jakóbik-Kolon, Anna Maciaszek, Barbara nawrot
    Conference:
    9th European Conference on Boron Chemistry (rok: 2022, ), Wydawca: ICMAB and CSIC
    Data:
    konferencja 3-7 lipca
    Status:
    Published
  14. Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase
    Authors:
    Katarzyna Ebenryter-Olbińska, Damian Kaniowski, Katarzyna Kulik, Ewelina Wielgus, Zbigniew Leśnikowski, Barbara Nawrot
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (rok: 2021, ), Wydawca: 63 PTCH
    Data:
    konferencja 2021-09-13-17
    Status:
    Published
  15. Nowe metody funkcjonalizacji klasterów boru i ich wykorzystanie do syntezy biokoniugatów
    Authors:
    S. Janczak, ZJ. Leśnikowski
    Conference:
    60 Zjazd PTCh (rok: 2017, ), Wydawca: PTCh
    Data:
    konferencja 17-21 września
    Status:
    Published
  16. Optimization of click reaction conditions on solid support for synthesis of oligofunctionalized carboranes
    Authors:
    K. Kulik, A. Maciaszek, Z. J. Leśnikowski, B. Nawrot
    Conference:
    XX International Symposium Advances in the Chemistry of Heteroorganic Compounds (rok: 2018, ), Wydawca: CBMM, PAN, PTCh
    Data:
    konferencja 45619
    Status:
    Published
  17. Post-synthetic modification of DNA-oligonucleotides with boron clusters using "click chemistry" methodology
    Authors:
    K. Ebenryter-Olbińska, Z.J. Leśnikowski, B. Nawrot
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2016, ), Wydawca: Uniwersytet im. Adama Mickiewicza
    Data:
    konferencja 19-23 września
    Status:
    Published
  18. Synthesis, anticancer and antiviral activity of novel 8-(4-substituted-1H-1,2,3-triazol-1-yl)purine derivatives
    Authors:
    D. Saftic, L. Glavas-Obrovac, M. Studzińska, E. Paradowska, ZJ. Leśnikowski, B. Zinic
    Conference:
    VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (rok: 2017, ), Wydawca: EFMC
    Data:
    konferencja August 27-31
    Status:
    Published
  19. Anti-EGFR silencing activity of antisense oligonucleotides labeled with boron clusters
    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, ZJ. Leśnikowski, B. Nawrot
    Conference:
    XVIIth Symposium on Chemistry of Nucleic Acid Components (rok: 2017, ), Wydawca: UOCHB AV CR
    Data:
    konferencja June 4-9
    Status:
    Published
  20. Application of boron clusters in nanoconstruction – present and future
    Authors:
    Leśnikowski Z.J.
    Conference:
    Nanotechnology and Nanomaterials (NANO-2018) (rok: 2018, ), Wydawca: National Academy of Sciences of Ukraine
    Data:
    konferencja 27-30 August
    Status:
    Published
  21. Nietypowa odporność na hydrolizę alkaliczną estrów p-nitrofenylowych cyklicznych tiofosforanów bishydroksymetalokarboranów
    Authors:
    S. Janczak, Z.J. Leśnikowski
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2016, ), Wydawca: Uniwersytet im. Adama Mickiewicza
    Data:
    konferencja 19-23 września
    Status:
    Published
  22. Oligofunkcjonalizacja klasterów boru jako bloków budulcowych nowych materiałów oraz związków bioaktywnych
    Authors:
    Krzysztof Śmiałkowski, Zbigniew Leśnikowski
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (rok: 2021, ), Wydawca: 63 PTCH
    Data:
    konferencja 2021-09-17-21
    Status:
    Published
  23. Synthesis and physico-chemical and biological properties of oligopods of boron clusters and antisense oligonucleotides
    Authors:
    Kaniowski, K. Ebenryter-Olbińska, K. Kulik, M. Sobczak, S. Janczak, Z. J. Leśnikowski and B. Nawrot
    Conference:
    XI Ogólnopolskie Sympozjum Chemii Heteroorganicznej (rok: 2018, ), Wydawca: OSCO
    Data:
    konferencja 8-11 kwietnia
    Status:
    Published
  24. Oligopods of antisense oligonucleotides with boron clusters: self-assembly and biological properties
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Milena Sobczak, Sławomir Janczak, Zbigniew J. Leśnikowski, Barbara Nawrot
    Conference:
    XXIII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (rok: 2018, ), Wydawca: UC San Diego
    Data:
    konferencja August 26-30
    Status:
    Published
  25. Antisense oligonucleotides conjugated with boron clusters as a dual-action therapeutic platform: anti-EGFR in cancer cells and BNCT
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Justyna Suwara, Agata Jakóbik-Kolon, Anna Maciaszek, Barbara Nawrot
    Conference:
    8th Central European Congress of Life Sciences EUROBIOTECH (rok: 2022, ), Wydawca: EXPO
    Data:
    konferencja 20-22 czerwiec
    Status:
    Published
  26. Aromaticity in 3D -Putting boron clusters at work
    Authors:
    C. Sardo, S. Janczak, ZJ. Leśnikowski
    Conference:
    XX International Symposium "Advances in the Chemistry of Heteroorganic Compounds" (rok: 2017, ), Wydawca: CBMiM PAN
    Data:
    konferencja November 23-24
    Status:
    Published
  27. Boron clusters oligopods: New tool for nanoconstruction
    Authors:
    Carla Sardo and Zbigniew J. Leśnikowski
    Conference:
    NanoTech Poland 2017 (rok: 2017, ), Wydawca: Uniwersytet im. Adama Mickiewicza, Poznań
    Data:
    konferencja 1st–3rd JUNE
    Status:
    Published
  28. Klastery boru skoniugowane z kwasami nukleinowymi – nowy materiał dla bionanotechnologii
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Anna Maciaszek, Zbigniew J. Leśnikowski, Barbara Nawrot
    Conference:
    STM/AFM NANOSAM (rok: 2018, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 28 listopada - 2 grudnia
    Status:
    Published
  29. Nanostructured conjugates of DNA oligonucleotides and boron clusters as potential dual-action anti-EGFR & BNCT therapeutics
    Authors:
    D.Kaniowski, K.Ebenryter-Olbińska, K.Kulik, A.Maciaszek, Z.J. Leśnikowski, B. Nawrot
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: FEBS PRESS
    Data:
    konferencja 6-11 July
    Status:
    Published
  30. Oligofunctionalization of cobalt-bis(1,2-dicarbollide)ate (COSAN) as a building block for nanoconstruction
    Authors:
    Krzysztof Śmiałkowski, Carla Sardo, Zbigniew Leśnikowskii
    Conference:
    9th European Conference on Boron Chemistry (rok: 2022, ), Wydawca: ICMAB and CSIC
    Data:
    konferencja 3-7 lipca
    Status:
    Published
  31. Oligofunkcjonalizacja metalokarboranów - Synteza pochodnych bis(1,2-dikarba-closo-undekaborano)-commo-3,3'-kobaltanu (III) (-1) podstawionych równocześnie na atomach węgla i boru
    Authors:
    Krzysztof Śmiałkowski, Zbigniew Leśnikowski
    Conference:
    VIII Ogólnopolskie Seminarium Postępy w Chemii Boru (rok: 2022, ), Wydawca: Politechnika Warszawska
    Data:
    konferencja 3-5 czerwca
    Status:
    Published
  32. Unusual resistance of metallacarborane O-(4-nitrophenyl)-phosphorothioate ester towards alkali hydrolysis
    Authors:
    Carla Sardo, Zbigniew Leśnikowski
    Conference:
    PBSi 2018 International Conference on Phosphorus, Boron and Silicon (rok: 2018, ), Wydawca: PremC
    Data:
    konferencja December 10-12
    Status:
    Published
  33. Anti-EGFR antisense oligonucleotides conjugated with metallacarboranyl clusters
    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, ZJ. Leśnikowski, B. Nawrot
    Conference:
    60 Zjazd PTCh (rok: 2017, ), Wydawca: PTCh
    Data:
    konferencja 17-21 września
    Status:
    Published
  34. Composites of Nucleic Acids and Oligofunctionalized Carboranes: synthesis, physicochemical and biological properties
    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, K. Kulik, M. Sobczak, S. Janczak, Z. J. Leśnikowski, B. Nawrot
    Conference:
    XX International Symposium Advances in the Chemistry of Heteroorganic Compounds (rok: 2018, ), Wydawca: CBMM PAN, PTCh
    Data:
    konferencja 45619
    Status:
    Published
  35. Composites of nucleic acids with oligofunctionalized carboranes as functional nanoparticles about two faces: anti-EGFR in cancer cells and carriers of boron for BNCT
    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Anna Maciaszek, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew J. Leśnikowski, Barbara Nawrot
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (rok: 2021, ), Wydawca: 63 PTCH
    Data:
    konferencja 2021-09-13-17
    Status:
    Published
  36. Conjugates of antisense oligonucleotides with boron clusters: new material for boron neutron capture therapy (BNCT)
    Authors:
    D.Kaniowski, K.Ebenryter-Olbińska, K.Kulik, A.Maciaszek, Z.J. Leśnikowski, B.Nawrot
    Conference:
    8th Intercollegiate Biotechnology Symposium 'Symbioza', Warsaw (rok: 2019, ), Wydawca: Politechnika Warszawska
    Data:
    konferencja 17-19 maj
    Status:
    Published
  37. Nanostructures of conjugates of antisense oligonucleotides and boron clusters as potential dual-action therapeutic nucleic acids
    Authors:
    . D.Kaniowski, K.Ebenryter-Olbińska, K.Kulik, A.Maciaszek, Z.J. Leśnikowski and B.Nawrot
    Conference:
    IFF Spring School Forschugszentrum (rok: 2019, ), Wydawca: Forschungszentrum Jülich
    Data:
    konferencja 11-22 marca
    Status:
    Published
  1. Boron Clusters as Redox Labels for Nucleosides and Nucleic Acids
    Authors:
    Agnieszka B. Olejniczak and Zbigniew J. Leśnikowski
    Book:
    Handbook of Boron Science with Applications in Organometallics, Catalysis, Materials, and Medicine (rok: 2018, tom: 4, strony: 45304), Wydawca: World Scientific
    Status:
    Published

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