Composites of nucleic acids and oligofunctionalized boron clusters as new material for bionanotechnology

2015/16/W/ST5/00413

Keywords

Descriptors

  • ST5_11: Synteza biomateriałów
  • ST5_10: Nanomateriały: nanocząstki, nanorurki
  • ST5_9: Materiały do konstrukcji sensorów

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Instytut Biologii Medycznej PAN

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Zbigniew Jan Leśnikowski

Number of co-investigators in the project: 9

Call

SYMFONIA 3 – announced on 2014-12-15

Amount awarded
3 430 080 PLN
Project start date
2015-11-16
Project end date
2022-11-15
Project duration
84 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Agregat chłodzący (2 pcs). Cost: 33 200 PLN
  2. DNA/RNA Syntetyzer. Cost: 180 000 PLN
  3. Liofilizator. Cost: 75 000 PLN
  4. Pompa hybrydowa. Cost: 25 000 PLN
  5. Reaktor mikrofalowy.
  6. Spektrofotometr przenośny w kropli. Cost: 39 800 PLN
  7. System do chromatografii kartridżowej. Cost: 270 000 PLN
  8. System wyparki obrotowej z wyposażeniem (2 pcs). Cost: 70 000 PLN
  9. Wirówka próżniowa typu "Speedvac". Cost: 55 000 PLN
  10. Wytrząsarka o ruchu koziołkującym, wielofuncyjna.. Cost: 32 000 PLN

Information in the final report

Publication in academic press/journals (17)

  1. Boron Clusters as a Platform for New Materials: Composites of Nucleic Acids and Oligofunctionalized Carboranes (C2B10H12) and their Assembly into Functional Nanoparticles

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Slawomir Janczak, Anna Maciaszek, Katarzyna Bednarska, Barbara Nawrot and Zbigniew Lesnikowski
    Academic press:
    Nanoscale (year: 2020, volume: 12, pages: 103-114), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C9NR06550D – link to the publication
  2. Recent developments with boron as a platform for novel drug design

    Authors:
    Zbigniew J. Leśnikowski
    Academic press:
    Expert Opinion on Drug Discovery (year: 2016, volume: 11, pages: 569–578), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17460441.2016.1174687 – link to the publication
  3. Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives

    Authors:
    Dijana Saftić, Biserka Žinić, Ljubica Glavaš-Obrovac, Mirosława Studzińska, Edyta Paradowska & Zbigniew J. Leśnikowski
    Academic press:
    Nucleosides, Nucleotides and Nucleic Acids (year: 2018, volume: 37, pages: 397-414), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15257770.2018.1485932 – link to the publication
  4. Insights into molecular structure of adenosine-boron cluster conjugates and theirs phenyl isosters as adenosine receptor ligands: Nuclear magnetic resonance, crystallographic and computational studies

    Authors:
    Daniel Baranowski, Adam Mieczkowski, Damian Trzybiński, Krzysztof Woźniak, Katarzyna Bednarska-Szczepaniak, Zofia Gdaniec, Zbigniew J. Leśnikowski
    Academic press:
    Journal of Molecular Structure (year: 2023, volume: 1274, pages: 134588), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2022.134588 – link to the publication
  5. EGFR-targeted cellular delivery of therapeutic nucleic acids mediated by boron clusters

    Authors:
    Kaniowski D., Suwara J., Ebenryter-Olbińska K., Jakóbik-Kolon A., Nawrot B.
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 14793), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232314793 – link to the publication
  6. High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Milena Sobczak, BłazejWojtczak, Sławomir Janczak, Zbigniew J. Lesnikowski, Barbara Nawrot
    Academic press:
    Molecules (year: 2017, volume: 22, pages: 46042), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22091393 – link to the publication
  7. Versatile Method for the Site-Specific Modification of DNA with Boron Clusters: Anti-Epidermal Growth Factor Receptor (EGFR) Antisense Oligonucleotide Case

    Authors:
    Katarzyna Ebenryter-Olbinska, Damian Kaniowski, Milena Sobczak, Błazej A. Wojtczak, Sławomir Janczak, Ewelina Wielgus, Barbara Nawrot, Zbigniew J. Lesnikowski
    Academic press:
    Chemistry A European Journal (year: 2017, volume: 23, pages: 16535 – 16546), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.201702957 – link to the publication
  8. Boron clusters as enhancers of RNase H activity in the smart strategy of gene silencing by antisense oligonucleotides

    Authors:
    Kaniowski D., Kulik K., Suwara J., Ebenryter-Olbińska K., Nawrot B.
    Academic press:
    International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 12190), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232012190 – link to the publication
  9. Unusual resistance of cobalt bis dicarbollide phosphate and phosphorothioate bridged esters towards alkaline hydrolysis: The metallacarborane effect

    Authors:
    Carla Sardo, Sławomir Janczak and Zbigniew J. Leśniowski
    Academic press:
    Journal of Organometallic Chemistry (year: 2019, volume: 896, pages: 70-76), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jorganchem.2019.06.001 – link to the publication
  10. DNA Modified with Boron–Metal Cluster Complexes [M(C2B9H11)2]—Synthesis, Properties, and Applications

    Authors:
    Agnieszka B. Olejniczak, Barbara Nawrot and Zbigniew J. Lesnikowski
    Academic press:
    International Journal of Molecular Sciences (year: 2018, volume: 19, pages: 46035), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19113501 – link to the publication
  11. Carborane- or Metallacarborane-Linked Nucleotides for Redox Labeling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing

    Authors:
    David Kodr, Cansu Pinar Yenice, Anna Simonova, Dijana Pavlović-Saftic, Radek Pohl, ́Veronika Sykorová, Mayreli Ortiz, Ludek Havran, Miroslav Fojta, Zbigniew J. Lesnikowski, Ciara K. O'Sullivan, Michal Hocek
    Academic press:
    Journal of American Chemical Society (year: 2021, volume: 143, pages: 7124-7134), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jacs.1c02222 – link to the publication
  12. Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism

    Authors:
    Edyta Paradowska, Mirosława Studzinska, Agnieszka Jabłonska, Valeri Lozovski, Natalia Rusinchuk, Iuliia Mukha, Nadiia Vitiuk, Zbigniew J. Lesnikowski
    Academic press:
    Molecules (year: 2021, volume: 26, pages: 5960), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26195960 – link to the publication
  13. Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2'-deoxyuridine boron cluster conjugate

    Authors:
    Dijana Saftić, Mirosława Studzińska, Edyta Paradowska, Ivo Piantanida, Goran Baranović, Magdalena Białek-Pietras and Zbigniew J. Leśnikowski
    Academic press:
    Bioorganic Chemistry (year: 2020, volume: 94, pages: 103466), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.103466 – link to the publication
  14. Intramolecular rotations and electronic states of iron in the iron bis(dicarbollide) complex Fe[(C2B9H11)2] studied by a 57Fe nuclear probe and computational methods.

    Authors:
    Katarzyna Bednarska-Szczepaniak, Katarzyna Dziedzic-Kocurek, Ewelina Przelazły, Jan Stanek and Zbigniew J. Leśnikowski
    Academic press:
    Chemical Communications (year: 2022, volume: 58, pages: 391-394), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1CC05111C – link to the publication
  15. What are the current challenges with the application of boron clusters to drug design?

    Authors:
    Zbigniew J. Leśnikowski
    Academic press:
    Expert Opinion on Drug Discovery (year: 2020, volume: 15, pages: 46025), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17460441.2021.1867531 – link to the publication
  16. Composites of Nucleic Acids and Boron Clusters (C2B10H12) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew Lesnikowski, Barbara Nawrot
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4863), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094863 – link to the publication
  17. Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

    Authors:
    Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus, Zbigniew Leśnikowski and Barbara Nawrot
    Academic press:
    Biomolecules (year: 2020, volume: 10, pages: 46042), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10050718 – link to the publication

Articles in post-conference publications (37)

  1. Comparative study of inorganic (boron cluster) and organic (phenyl) adenosine modifications as adenosine receptors ligands: Synthesis, in silico docking and physicochemical and biological evaluation

    Authors:
    Aleksandra Kierozalska, Adam Mieczkowski, Dijana Saftić, Katarzyna Bednarska, Tomasz Przygodzki, Kamil Karolczak, Cezary Watała, Magdalena Białek-Pietras, Tomasz M. Goszczyński, Mirosława Studzińska, Edyta Paradowska, Harsha Rao, Zhan-Guo Gao, Kenneth A. Jacobson and Zbigniew J. Leśnikowski
    Conference:
    8th European Conference on Boron Chemistry (EUROBORON 8) (year: 2019, pages: 50), Publisher: Universite de Montpellier
    Date:
    conference 24-28 June 2019, Montpellier
    Status:
    Published
  2. Klastery boru skoniugowane z kwasami nukleinowymi – nowy materiał dla bionanotechnologii

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Anna Maciaszek, Zbigniew J. Leśnikowski, Barbara Nawrot
    Conference:
    STM/AFM NANOSAM (year: 2018, pages: P-I-7), Publisher: Uniwersytet Jagielloński
    Date:
    conference 28 listopada - 2 grudnia
    Status:
    Published
  3. Functionalization of metallacarboranes – Synthesis of cobalt bis dicarbollide cyclic phosphorothioate ester and its alkylation

    Authors:
    Carla Sardo, Róża Hamera-Fałdyga, Krzysztof Śmiałkowski, Zbigniew Leśnikowski
    Conference:
    XXII International Symposium Advances in the Chemistry of Heteroorganic Compounds (year: 2019, pages: P-105), Publisher: CBMiM PAN, PTCh
    Date:
    conference 22 listopada
    Status:
    Published
  4. Synthesis and physico-chemical and biological properties of oligopods of boron clusters and antisense oligonucleotides

    Authors:
    Kaniowski, K. Ebenryter-Olbińska, K. Kulik, M. Sobczak, S. Janczak, Z. J. Leśnikowski and B. Nawrot
    Conference:
    XI Ogólnopolskie Sympozjum Chemii Heteroorganicznej (year: 2018, pages: P-24), Publisher: OSCO
    Date:
    conference 8-11 kwietnia
    Status:
    Published
  5. Composites of nucleic acids with oligofunctionalized carboranes as functional nanoparticles about two faces: anti-EGFR in cancer cells and carriers of boron for BNCT

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Anna Maciaszek, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew J. Leśnikowski, Barbara Nawrot
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (year: 2021, pages: S02 P019), Publisher: 63 PTCH
    Date:
    conference 2021-09-13-17
    Status:
    Published
  6. Composites of nucleic acids with oligofunctionalized carboranes (C2B10H12) as functional nanoparticles for downregulation of EGFR in cancer cells and carriers of boron for BNCT

    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, K. Kulik, A. Maciaszek, Agata Jakóbik-Kolon, Z.J. Leśnikowski and B. Nawrot
    Conference:
    Cold Spring Harbour Laboratory (year: 2021, pages: 44), Publisher: Cold Spring Harbour Laboratory
    Date:
    conference 2021-03-24-26
    Status:
    Published
  7. Nanostructures of conjugates of antisense oligonucleotides and boron clusters as potential dual-action therapeutic nucleic acids

    Authors:
    . D.Kaniowski, K.Ebenryter-Olbińska, K.Kulik, A.Maciaszek, Z.J. Leśnikowski and B.Nawrot
    Conference:
    IFF Spring School Forschugszentrum (year: 2019, pages: 30), Publisher: Forschungszentrum Jülich
    Date:
    conference 11-22 marca
    Status:
    Published
  8. Conjugates of antisense oligonucleotides with boron clusters: new material for boron neutron capture therapy (BNCT)

    Authors:
    D.Kaniowski, K.Ebenryter-Olbińska, K.Kulik, A.Maciaszek, Z.J. Leśnikowski, B.Nawrot
    Conference:
    8th Intercollegiate Biotechnology Symposium 'Symbioza', Warsaw (year: 2019, pages: P15), Publisher: Politechnika Warszawska
    Date:
    conference 17-19 maj
    Status:
    Published
  9. Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

    Authors:
    Katarzyna Ebenryter-Olbińska, Damian Kaniowski, Katarzyna Kulik, Ewelina Wielgus, Zbigniew Leśnikowski, Barbara Nawrot
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (year: 2021, pages: S02 P021), Publisher: 63 PTCH
    Date:
    conference 2021-09-13-17
    Status:
    Published
  10. New conjugates of DNA-boron clusters with two faces

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Anna Maciaszek, Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew J. Leśnikowski and Barbara Nawrot
    Conference:
    IS3NA-IRT Virtual Virtual Symposium Symposium (year: 2021, pages: PL12), Publisher: International Society of Nucleosides, Nucleotides and Nucleic Acids
    Date:
    conference 2021-08-26-27
    Status:
    Published
  11. Anti-EGFR silencing activity of antisense oligonucleotides labeled with boron clusters

    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, ZJ. Leśnikowski, B. Nawrot
    Conference:
    XVIIth Symposium on Chemistry of Nucleic Acid Components (year: 2017, pages: 154), Publisher: UOCHB AV CR
    Date:
    conference June 4-9
    Status:
    Published
  12. Anti-EGFR antisense oligonucleotides conjugated with metallacarboranyl clusters

    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, ZJ. Leśnikowski, B. Nawrot
    Conference:
    60 Zjazd PTCh (year: 2017, pages: 604), Publisher: PTCh
    Date:
    conference 17-21 września
    Status:
    Published
  13. Aromaticity in 3D -Putting boron clusters at work

    Authors:
    C. Sardo, S. Janczak, ZJ. Leśnikowski
    Conference:
    XX International Symposium Advances in the Chemistry of Heteroorganic Compounds (year: 2017, pages: P-033), Publisher: CBMiM PAN
    Date:
    conference November 23-24
    Status:
    Published
  14. Synthesis, anticancer and antiviral activity of novel 8-(4-substituted-1H-1,2,3-triazol-1-yl)purine derivatives

    Authors:
    D. Saftic, L. Glavas-Obrovac, M. Studzińska, E. Paradowska, ZJ. Leśnikowski, B. Zinic
    Conference:
    VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (year: 2017, pages: P351), Publisher: EFMC
    Date:
    conference August 27-31
    Status:
    Published
  15. Nietypowa odporność na hydrolizę alkaliczną estrów p-nitrofenylowych cyklicznych tiofosforanów bishydroksymetalokarboranów

    Authors:
    S. Janczak, Z.J. Leśnikowski
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2016, pages: 132 S03P09), Publisher: Uniwersytet im. Adama Mickiewicza
    Date:
    conference 19-23 września
    Status:
    Published
  16. Development of a dual fluorescence assay for monitoring of anti-EGFR silencing activity of chemically modified oligonucleotides; construction of pGFP-EGFR fusion plasmid

    Authors:
    D. Kaniowski, B. Nawrot
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2016, pages: 89 S01P35), Publisher: Uniwersytet im. Adama Mickiewicza
    Date:
    conference 19-23 września
    Status:
    Published
  17. Boron clusters oligopods: New tool for nanoconstruction

    Authors:
    Carla Sardo and Zbigniew J. Leśnikowski
    Conference:
    NanoTech Poland 2017 (year: 2017, pages: 183), Publisher: Uniwersytet im. Adama Mickiewicza, Poznań
    Date:
    conference 1st–3rd JUNE
    Status:
    Published
  18. Synthesis, physicochemical and biological properties of DNA oligonucleotides modified with boron clusters

    Authors:
    Katarzyna Ebenryter-Olbińska, Damian Kaniowski, Zbigniew Leśnikowski, Barbara Nawrot
    Conference:
    XIX International Symposium Advances in the Chemistry of Heteroorganic Compounds (year: 2016, pages: P059), Publisher: Polskie Towarzystwo Chemiczne
    Date:
    conference 25 listopada
    Status:
    Published
  19. Synthesis and physicochemical modification of antisense oligonucleotides modified with boron clusters

    Authors:
    K. Ebenryter-Olbińska, M. Sobczak, D. Kaniowski, ZJ. Leśnikowski, B. Nawrot
    Conference:
    XVIIth Symposium on Chemistry of Nucleic Acid Components (year: 2017, pages: 133), Publisher: UOCHB AV CR
    Date:
    conference June 4-9
    Status:
    Published
  20. BORON CLUSTERS – FROM NANOMACHINES TO DNA-NANOCONSTRUCTION

    Authors:
    Zbigniew J. Lesnikowski
    Conference:
    NANOTECH POLAND 2016 Conference and Exhibition (year: 2016, pages: 144), Publisher: Centrum NanoBioMedyczne Uniwersytetu im . Adama Mickiewicza w Poznaniu
    Date:
    conference 22-25 czerwca
    Status:
    Published
  21. Composites of Nucleic Acids and Oligofunctionalized Carboranes: synthesis, physicochemical and biological properties

    Authors:
    D. Kaniowski, K. Ebenryter-Olbińska, K. Kulik, M. Sobczak, S. Janczak, Z. J. Leśnikowski, B. Nawrot
    Conference:
    XX International Symposium Advances in the Chemistry of Heteroorganic Compounds (year: 2018, pages: P-118), Publisher: CBMM PAN, PTCh
    Date:
    conference 46349
    Status:
    Published
  22. Effect of boron cluster substitution on electronic properties of purine chromophore in adenosine nucleosides

    Authors:
    Aleksandra Kierozalska, Carla Sardo, Zbigniew J. Lenikowski
    Conference:
    XXI International Symposium Advances in the Chemistry of Heteroorganic Compounds (year: 2018, pages: P-039), Publisher: CBMM PAN, PTCh
    Date:
    conference 46349
    Status:
    Published
  23. Post-synthetic modification of DNA-oligonucleotides with boron clusters using click chemistry methodology

    Authors:
    K. Ebenryter-Olbińska, Z.J. Leśnikowski, B. Nawrot
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (year: 2016, pages: 88 S01P33), Publisher: Uniwersytet im. Adama Mickiewicza
    Date:
    conference 19-23 września
    Status:
    Published
  24. Oligopods of antisense oligonucleotides with boron clusters: self-assembly and biological properties

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Katarzyna Kulik, Milena Sobczak, Sławomir Janczak, Zbigniew J. Leśnikowski, Barbara Nawrot
    Conference:
    XXIII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids (year: 2018, pages: P-168), Publisher: UC San Diego
    Date:
    conference August 26-30
    Status:
    Published
  25. Optimization of click reaction conditions on solid support for synthesis of oligofunctionalized carboranes

    Authors:
    K. Kulik, A. Maciaszek, Z. J. Leśnikowski, B. Nawrot
    Conference:
    XX International Symposium Advances in the Chemistry of Heteroorganic Compounds (year: 2018, pages: P-117), Publisher: CBMM, PAN, PTCh
    Date:
    conference 46349
    Status:
    Published
  26. Nowe metody funkcjonalizacji klasterów boru i ich wykorzystanie do syntezy biokoniugatów

    Authors:
    S. Janczak, ZJ. Leśnikowski
    Conference:
    60 Zjazd PTCh (year: 2017, pages: 591), Publisher: PTCh
    Date:
    conference 17-21 września
    Status:
    Published
  27. Antiviral effect of non-functionalized gold nanoparticles against herpes simplex virus type 1 (HSV-1)

    Authors:
    Leśnikowski Z., Paradowska E., Studzińska M., Lozovski V., Rusinchuk N., Mukha Iu., Vityuk N.
    Conference:
    Nanotechnology and Nanomaterials (NANO-2018) (year: 2018, pages: 8), Publisher: National Academy of Sciences of Ukraine
    Date:
    conference 27-30 August
    Status:
    Published
  28. Unusual resistance of metallacarborane O-(4-nitrophenyl)-phosphorothioate ester towards alkali hydrolysis

    Authors:
    Carla Sardo, Zbigniew Leśnikowski
    Conference:
    PBSi 2018 International Conference on Phosphorus, Boron and Silicon (year: 2018, pages: 148), Publisher: PremC
    Date:
    conference December 10-12
    Status:
    Published
  29. Application of boron clusters in nanoconstruction – present and future

    Authors:
    Leśnikowski Z.J.
    Conference:
    Nanotechnology and Nanomaterials (NANO-2018) (year: 2018, pages: 394-395), Publisher: National Academy of Sciences of Ukraine
    Date:
    conference 27-30 August
    Status:
    Published
  30. Composites of DNA and boron clusters and their assembly into functional nanoparticles

    Authors:
    Katarzyna Ebenryter-Olbińska, Krzysztof Śmiałkowski, Carla Sardo, Damian Kaniowski, Gabriela Gajek, Katarzyna Bednarska-Szczepaniak, Lidia Żukowska, Barbara Nawrot and Zbigniew J. Leśnikowski
    Conference:
    9th European Conference on Boron Chemistry (year: 2022, pages: 21), Publisher: ICMAB and CSIC
    Date:
    conference 3-7 lipca
    Status:
    Published
  31. Oligofunkcjonalizacja metalokarboranów - Synteza pochodnych bis(1,2-dikarba-closo-undekaborano)-commo-3,3'-kobaltanu (III) (-1) podstawionych równocześnie na atomach węgla i boru

    Authors:
    Krzysztof Śmiałkowski, Zbigniew Leśnikowski
    Conference:
    VIII Ogólnopolskie Seminarium Postępy w Chemii Boru (year: 2022, pages: 18), Publisher: Politechnika Warszawska
    Date:
    conference 3-5 czerwca
    Status:
    Published
  32. Highly boron-loaded antisense oligonucleotides conjugated with target-directed ligands for dual anticancer therapy: anti-EGFR and BNCT

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbińska, Justyna Suwara, Agata Jakóbik-Kolon, Anna Maciaszek, Barbara nawrot
    Conference:
    9th European Conference on Boron Chemistry (year: 2022, pages: 127), Publisher: ICMAB and CSIC
    Date:
    conference 3-7 lipca
    Status:
    Published
  33. Antisense oligonucleotides conjugated with boron clusters as a dual-action therapeutic platform: anti-EGFR in cancer cells and BNCT

    Authors:
    Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Justyna Suwara, Agata Jakóbik-Kolon, Anna Maciaszek, Barbara Nawrot
    Conference:
    8th Central European Congress of Life Sciences EUROBIOTECH (year: 2022, pages: O11), Publisher: EXPO
    Date:
    conference 20-22 czerwiec
    Status:
    Published
  34. Oligofunctionalization of cobalt-bis(1,2-dicarbollide)ate (COSAN) as a building block for nanoconstruction

    Authors:
    Krzysztof Śmiałkowski, Carla Sardo, Zbigniew Leśnikowskii
    Conference:
    9th European Conference on Boron Chemistry (year: 2022, pages: 150), Publisher: ICMAB and CSIC
    Date:
    conference 3-7 lipca
    Status:
    Published
  35. Oligofunkcjonalizacja klasterów boru jako bloków budulcowych nowych materiałów oraz związków bioaktywnych

    Authors:
    Krzysztof Śmiałkowski, Zbigniew Leśnikowski
    Conference:
    63 Zjazd Polskiego Towarzystwa Chemicznego (year: 2021, pages: S01 KS04), Publisher: 63 PTCH
    Date:
    conference 2021-09-17-21
    Status:
    Published
  36. Nanostructured conjugates of DNA oligonucleotides and boron clusters as potential dual-action anti-EGFR & BNCT therapeutics

    Authors:
    D.Kaniowski, K.Ebenryter-Olbińska, K.Kulik, A.Maciaszek, Z.J. Leśnikowski, B. Nawrot
    Conference:
    The 44th FEBS Congress (year: 2019, pages: 209), Publisher: FEBS PRESS
    Date:
    conference 6-11 July
    Status:
    Published
  37. Unusual chirality of metallacarboranes containing phosphorothioate bridging moiety

    Authors:
    Krzysztof Śmiałkowski, Carla Sardo, Zbigniew Leśnikowski
    Conference:
    23 International Conference on Phosphorus Chemistry (year: 2021, pages: P-099), Publisher: AJD
    Date:
    conference 2021-07-5-9
    Status:
    Published

Book publications / chapters in book publications (1)

  1. Boron Clusters as Redox Labels for Nucleosides and Nucleic Acids

    Authors:
    Agnieszka B. Olejniczak and Zbigniew J. Leśnikowski
    Book:
    Handbook of Boron Science with Applications in Organometallics, Catalysis, Materials, and Medicine (year: 2018, volume: 4, pages: 46035), Publisher: World Scientific
    Status:
    Published

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