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The structural consequences of lysenin oligomerization- a toxin specifically binding sphingomyelin in lipid rafts

2014/15/D/NZ1/03343

Keywords:

protein structure toxin lipid rafts sphingomyelin receptor plasma membrane

Descriptors:

  • NZ1_4: Structural biology
  • NZ3_1: Cell biology
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Kulma 

Number of co-investigators in the project: 2

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 711 620 PLN

Project start date (Y-m-d): 2015-07-21

Project end date (Y-m-d): 2019-07-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Insight into the Structural Dynamics of the Lysenin During Prepore-to-Pore Transition Using Hydrogen-Deuterium Exchange Mass Spectrometry.
    Authors:
    Magdalena Kulma, Michał Dadlez, Katarzyna Kwiatkowska
    Academic press:
    Toxins (rok: 2019, tom: 11(8), strony: pii: E462), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/toxins11080462 - link to the publication
  2. R468A mutation in perfringolysin O destabilizes toxin structure and induces membrane fusion
    Authors:
    Magdalena Kulma, Aleksandra Kacprzyk-Stokowiec, Katarzyna Kwiatkowska, Gabriela Traczyk, Andrzej Sobota , Michał Dadlez
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Biomembranes (rok: 2017, tom: 1859(6), strony: 1075-1088), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2017.03.001 - link to the publication
  3. Fine-tuning of the stability of β-strands by Y181 in perfringolysin O directs the prepore to pore transition.
    Authors:
    Magdalena Kulma, Aleksandra Kacprzyk-Stokowiec, Gabriela Traczyk, Katarzyna Kwiatkowska, Michał Dadlez
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Biomembranes (rok: 2019, tom: 1861(1), strony: 110-122), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2018.08.008 - link to the publication

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