Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms of microRNA activity and expression changes in myotonic dystrophy

2014/15/B/NZ2/02453

Keywords:

microRNA NGS myotonic dystrophy triplet repeat expansion

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Sobczak 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 565 000 PLN

Project start date (Y-m-d): 2015-07-23

Project end date (Y-m-d): 2019-07-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. homogenizator.
  2. zamrażarka.
  3. termocykler (45 000 PLN)
  4. zestaw pipet automatycznych (10 000 PLN)
  5. chłodziarko-zamrażarka.
  6. urządzenie do hybrydyzacji typu "dot bot" (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Application of ion pair chromatography coupled with mass spectrometry to assess antisense oligonucleotides concentrations in living cells.
    Authors:
    Studzinska S, Cywoniuk P, Sobczak K.
    Academic press:
    Analyst (rok: 2019, tom: 144, strony: 622-633), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8an01603h - link to the publication
  2. DYSTROFIA MIOTONICZNA – PATOMECHANIZM MOLEKULARNY I STRATEGIE TERAPEUTYCZNE
    Authors:
    Kajdasz A., Sobczak K.
    Academic press:
    Postępy Biologii Komórki (rok: 2016, tom: 43, strony: 27-52), Wydawca: POLSKIE TOWARZYSTWO ANATOMICZNE
    Status:
    Published
    DOI:
    brak - link to the publication
  3. MEF2C shapes the microtranscriptome during differentiation of skeletal muscles
    Authors:
    Agnieszka Piasecka, Michał Sekrecki, Michał Wojciech Szcześniak and Krzysztof Sobczak
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 3476), Wydawca: NATURE RESEARCH
    Status:
    Published
    DOI:
    10.1038/s41598-021-82706-2 - link to the publication
  4. Mechanistic determinants of MBNL activity.
    Authors:
    Sznajder ŁJ, Michalak M, Taylor K, Cywoniuk P, Kabza M, Wojtkowiak-Szlachcic A, Matłoka M, Konieczny P, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 10326-10342), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkw915 - link to the publication
  5. MBNL expression in autoregulatory feedback loops.
    Authors:
    Konieczny P, Stepniak-Konieczna E, Sobczak K.
    Academic press:
    RNA Biology (rok: 2018, tom: 15, strony: 45299), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15476286.2017.1384119 - link to the publication
  6. Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.
    Authors:
    Konieczny P, Stepniak-Konieczna E, Taylor K, Sznajder LJ, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2017, tom: 45, strony: 1760-1775), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkw1158 - link to the publication
  7. Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.
    Authors:
    Cywoniuk P, Taylor K, Sznajder ŁJ, Sobczak K.
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 17587), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-017-17816-x - link to the publication
  8. Global Increase in Circular RNA Levels in Myotonic Dystrophy
    Authors:
    Czubak K, Taylor K, Piasecka A, Sobczak K, Kozlowska K, Philips A, Sedehizadeh S, Brook JD, Wojciechowska M, Kozlowski P.
    Academic press:
    Frontiers in Genetics (rok: 2019, tom: 10, strony: 649), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fgene.2019.00649 - link to the publication
  9. MBNL splicing activity depends on RNA binding site structural context.
    Authors:
    Taylor K, Sznajder LJ, Cywoniuk P, Thomas JD, Swanson MS, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2018, tom: 46, strony: 9119–9133), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gky565 - link to the publication
  10. Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy
    Authors:
    Wojciechowska M, Sobczak K, Kozlowski P, Sedehizadeh S, Wojtkowiak-Szlachcic A, Czubak K, Markus R, Lusakowska A, Kaminska A, Brook JD.
    Academic press:
    Scientific Raports (rok: 2018, tom: 8, strony: 5885), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-24156-x - link to the publication

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