Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Mechanisms of microRNA activity and expression changes in myotonic dystrophy

2014/15/B/NZ2/02453

Keywords:

microRNA NGS myotonic dystrophy triplet repeat expansion

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Sobczak 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 565 000 PLN

Project start date (Y-m-d): 2015-07-23

Project end date (Y-m-d): 2019-07-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. urządzenie do hybrydyzacji typu "dot bot" (15 000 PLN)
  2. zestaw pipet automatycznych (10 000 PLN)
  3. chłodziarko-zamrażarka.
  4. homogenizator.
  5. termocykler (45 000 PLN)
  6. zamrażarka.

Information in the final report

  • Publication in academic press/journals (10)
  1. DYSTROFIA MIOTONICZNA – PATOMECHANIZM MOLEKULARNY I STRATEGIE TERAPEUTYCZNE
    Authors:
    Kajdasz A., Sobczak K.
    Academic press:
    Postępy Biologii Komórki (rok: 2016, tom: 43, strony: 27-52), Wydawca: POLSKIE TOWARZYSTWO ANATOMICZNE
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Hybrid splicing minigene and antisense oligonucleotides as efficient tools to determine functional protein/RNA interactions.
    Authors:
    Cywoniuk P, Taylor K, Sznajder ŁJ, Sobczak K.
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 17587), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-017-17816-x - link to the publication
  3. Global Increase in Circular RNA Levels in Myotonic Dystrophy
    Authors:
    Czubak K, Taylor K, Piasecka A, Sobczak K, Kozlowska K, Philips A, Sedehizadeh S, Brook JD, Wojciechowska M, Kozlowski P.
    Academic press:
    Frontiers in Genetics (rok: 2019, tom: 10, strony: 649), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fgene.2019.00649 - link to the publication
  4. Mechanistic determinants of MBNL activity.
    Authors:
    Sznajder ŁJ, Michalak M, Taylor K, Cywoniuk P, Kabza M, Wojtkowiak-Szlachcic A, Matłoka M, Konieczny P, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 10326-10342), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkw915 - link to the publication
  5. Quantitative Methods to Monitor RNA Biomarkers in Myotonic Dystrophy
    Authors:
    Wojciechowska M, Sobczak K, Kozlowski P, Sedehizadeh S, Wojtkowiak-Szlachcic A, Czubak K, Markus R, Lusakowska A, Kaminska A, Brook JD.
    Academic press:
    Scientific Raports (rok: 2018, tom: 8, strony: 5885), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-24156-x - link to the publication
  6. Application of ion pair chromatography coupled with mass spectrometry to assess antisense oligonucleotides concentrations in living cells.
    Authors:
    Studzinska S, Cywoniuk P, Sobczak K.
    Academic press:
    Analyst (rok: 2019, tom: 144, strony: 622-633), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8an01603h - link to the publication
  7. Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript.
    Authors:
    Konieczny P, Stepniak-Konieczna E, Taylor K, Sznajder LJ, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2017, tom: 45, strony: 1760-1775), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkw1158 - link to the publication
  8. MBNL splicing activity depends on RNA binding site structural context.
    Authors:
    Taylor K, Sznajder LJ, Cywoniuk P, Thomas JD, Swanson MS, Sobczak K.
    Academic press:
    Nucleic Acids Research (rok: 2018, tom: 46, strony: 9119–9133), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gky565 - link to the publication
  9. MBNL expression in autoregulatory feedback loops.
    Authors:
    Konieczny P, Stepniak-Konieczna E, Sobczak K.
    Academic press:
    RNA Biology (rok: 2018, tom: 15, strony: 45299), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/15476286.2017.1384119 - link to the publication
  10. MEF2C shapes the microtranscriptome during differentiation of skeletal muscles
    Authors:
    Agnieszka Piasecka, Michał Sekrecki, Michał Wojciech Szcześniak and Krzysztof Sobczak
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 3476), Wydawca: NATURE RESEARCH
    Status:
    Published
    DOI:
    10.1038/s41598-021-82706-2 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy