Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Immunomodulatory effects of sildenafil citrate in women with recurrent pregnancy loss

2014/15/D/NZ7/01838

Keywords:

sildenafil,Nk cells recurrent pregnancy loss with unexplain reason

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Monika Kniotek 

Number of co-investigators in the project: 6

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 389 560 PLN

Project start date (Y-m-d): 2015-08-10

Project end date (Y-m-d): 2020-05-09

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Brinkubator-komora modulująca warunki hodowli-MIC 101 (2 475 PLN)
  2. Instalacja i szkolenie z obsługi Bricubator MIC-101 (500 PLN)
  3. Podwójny miernik przeplywu gazów-DFM 3002 (2 405 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Differences in immune checkpoints expression (TIM-3 and PD-1) on T cells in women with recurrent miscarriages - preliminary studies
    Authors:
    Michał Zych, Aleksander Roszczyk, Monika Kniotek, Filip Dąbrowski Radosław Zagożdżon
    Academic press:
    Journal of Clinical Medicine , Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Decreased Production of TNF-α and IL-6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women
    Authors:
    Monika Kniotek, Michał Zych, Aleksander Roszczyk, Monika Szafarowska, Małgorzata Jerzak
    Academic press:
    Journal of Clinical Medicine (rok: 2021, tom: 10(14), strony: 3115), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10143115 - link to the publication
  3. Sildenafil Citrate Influences Production of TNF-α in Healthy Men Lymphocytes
    Authors:
    Michał Zych,1 Aleksander Roszczyk,1 Monika Kniotek ,1 Beata Kaleta ,1 and Radoslaw Zagozdzon 1,2
    Academic press:
    Journal of Immunology Research (rok: 2019, tom: 2019, strony: 6), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/8478750 - link to the publication
  4. Differences in the Expression of KIR, ILT Inhibitory Receptors, and VEGF Production in the Induced Decidual NK Cell Cultures of Fertile and RPL Women
    Authors:
    Monika Kniotek , Aleksander Roszczyk , Michał Zych , Monika Szafarowska , Małgorzata Jerzak
    Academic press:
    BioMed Research International (rok: 2021, tom: 2021, strony: Article ID 6673427), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6673427 - link to the publication
  5. Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients
    Authors:
    Monika Kniotek, Agnieszka Boguska
    Academic press:
    Journal of Immunology Research (rok: 2017, tom: 2017, strony: 8, Article ID 4541958), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/4541958 - link to the publication

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