Immunomodulatory effects of sildenafil citrate in women with recurrent pregnancy loss

2014/15/D/NZ7/01838

Keywords

Descriptors

  • NZ6_2: Immunologia kliniczna
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Monika Joanna Kniotek

Number of co-investigators in the project: 6

Call

SONATA 8 – announced on 2014-09-15

Amount awarded
389 560 PLN
Project start date
2015-08-10
Project end date
2020-05-09
Project duration
57 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Brinkubator-komora modulująca warunki hodowli-MIC 101. Cost: 2 475 PLN
  2. Instalacja i szkolenie z obsługi Bricubator MIC-101. Cost: 500 PLN
  3. Podwójny miernik przeplywu gazów-DFM 3002. Cost: 2 405 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Sildenafil Citrate Influences Production of TNF-α in Healthy Men Lymphocytes

    Authors:
    Michał Zych,1 Aleksander Roszczyk,1 Monika Kniotek ,1 Beata Kaleta ,1 and Radoslaw Zagozdzon 1,2
    Academic press:
    Journal of Immunology Research (year: 2019, volume: 2019, pages: 6), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/8478750 – link to the publication
  2. Decreased Production of TNF-α and IL-6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women

    Authors:
    Monika Kniotek, Michał Zych, Aleksander Roszczyk, Monika Szafarowska, Małgorzata Jerzak
    Academic press:
    Journal of Clinical Medicine (year: 2021, volume: 10(14), pages: 3115), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10143115 – link to the publication
  3. Differences in the Expression of KIR, ILT Inhibitory Receptors, and VEGF Production in the Induced Decidual NK Cell Cultures of Fertile and RPL Women

    Authors:
    Monika Kniotek , Aleksander Roszczyk , Michał Zych , Monika Szafarowska , Małgorzata Jerzak
    Academic press:
    BioMed Research International (year: 2021, volume: 2021, pages: Article ID 6673427), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2021/6673427 – link to the publication
  4. Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

    Authors:
    Monika Kniotek, Agnieszka Boguska
    Academic press:
    Journal of Immunology Research (year: 2017, volume: 2017, pages: 8, Article ID 4541958), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/4541958 – link to the publication
  5. Differences in immune checkpoints expression (TIM-3 and PD-1) on T cells in women with recurrent miscarriages - preliminary studies

    Authors:
    Michał Zych, Aleksander Roszczyk, Monika Kniotek, Filip Dąbrowski Radosław Zagożdżon
    Status:
    Accepted for publication

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Graphic design and implementation: Jakub Piotrowski