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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of the factors secreted by senescent vascular smooth muscle cells in the modulation in the functioning of the immune cells.

2014/15/B/NZ3/01150

Keywords:

cellular senescence secretome vascular smooth muscle cells atherosclerosis

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_4: Ageing

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grażyna Mosieniak 

Number of co-investigators in the project: 9

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 317 000 PLN

Project start date (Y-m-d): 2015-07-23

Project end date (Y-m-d): 2019-07-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. wirówka wielofunkcyjna (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Unbiased proteomic analysis of extracellular vesicles secreted by senescent human vascular smooth muscle cells reveals their ability to modulate immune cell functions
    Authors:
    Agata Głuchowska, Dominik Cysewski Monika Baj-Krzyworzeka , Rafał Szatanek, Kazimierz Węglarczyk, Paulina Podszywałow-Bartnicka, Piotr Sunderland, Ewa Kozłowska, Małgorzata A Śliwińska, Michał Dąbrowski, Ewa Sikora, Grażyna Mosieniak
    Academic press:
    GeroScience (rok: 2022, ), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-022-00625-0 - link to the publication
  2. A common signature of cellular senescence; does it exist?
    Authors:
    Ewa Sikora, Anna Bielak-Zmijewska, Grazyna Mosieniak
    Academic press:
    Ageing Research Reviews (rok: 2021, tom: 71, strony: 101458), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2021.101458. - link to the publication
  3. Targeting normal and cancer senescent cells as a strategy of senotherapy
    Authors:
    Sikora E, Bielak-Zmijewska A, Mosieniak G.
    Academic press:
    Ageing Res Rev (rok: 2019, tom: 55, strony: 100941), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2019.100941 - link to the publication
  4. NOX4 downregulation leads to senescence of human vascular smooth muscle cells
    Authors:
    Dorota Przybylska, Dorota Janiszewska, Aleksandra Goździk, Anna Bielak-Zmijewska, Piotr Sunderland, Ewa Sikora, Grażyna Mosieniak
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 66429-66443), Wydawca: Mikhail V. Blagosklonny
    Status:
    Published
    DOI:
    10.18632/oncotarget.12079 - link to the publication

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