Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Synthesis, characteristics and activity of biopolymer-based modified magnetic nanoparticles as potential carriers for enzymes in synthesis of beta-adrenolytic drugs

2014/15/B/NZ7/00972

Keywords:

activity beta-adrenolytic drugs magnetic nanoparticles enzyme carriers

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects
  • ST8_8: Mechanics of solids

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Michał Marszałł 

Number of co-investigators in the project: 3

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 887 875 PLN

Project start date (Y-m-d): 2015-07-14

Project end date (Y-m-d): 2018-07-13

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Waga precyzyjna (1 715 PLN)
  2. Aparat do pomiaru wielkości oraz potencjału zeta nanocząstek (160 000 PLN)
  3. Aparat do ultra wysokosprawnej chromatografii cieczowej (UHPLC) (255 000 PLN)
  4. Wytrząsarka laboratoryjna.
  5. Wytsząsarka laboratoryjna z kontrolą temperatury.

Information in the final report

  • Publication in academic press/journals (5)
  1. Enantioseparation of (RS)-atenolol with the use of lipases immobilized onto new-synthesized magnetic nanoparticles.
    Authors:
    A. Sikora, D. Chełminiak-Dudkiewicz, M. Ziegler-Borowska, M.P. Marszałł
    Academic press:
    Tetrahedron-Asymmetry (rok: 2017, tom: 28, strony: 374–380), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.01.012 - link to the publication
  2. Chitosan–Collagen Coated Magnetic Nanoparticles for Lipase Immobilization—New Type of Enzyme Friendly" Polymer Shell Crosslinking with Squaric Acid
    Authors:
    M. Ziegler-Borowska, D. Chelminiak-Dudkiewicz, T. Siódmiak, A. Sikora, K. Wegrzynowska-Drzymalska, J. Skopinska-Wisniewska, H. Kaczmarek, M. P. Marszałł
    Academic press:
    Catalysts (rok: 2017, tom: 7, strony: 45305), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/catal7010026 - link to the publication
  3. Lipases - Valuable Biocatalysts in Kinetic Resolution of Racemates
    Authors:
    Agata Tarczykowska, Adam Sikora and Michal Piotr Marszall
    Academic press:
    Mini-Reviews in Organic Chemistry (rok: 2018, tom: 15(5), strony: 374-381), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1570193X15666171228145012 - link to the publication
  4. Kinetic Resolution of (R,S)-atenolol with the Use of Lipases in Various Organic Solvents
    Authors:
    A. Sikora, W.D. Sroka, T. Siódmiak, M.P. Marszałł
    Academic press:
    Current Organic Synthesis (rok: 2017, tom: 14, strony: 747-754), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1570179414666161230120414 - link to the publication
  5. Enantioselective acetylation of (R,S)-atenolol: The use of Candida rugosa lipases immobilized onto magnetic chitosan nanoparticles in enzyme-catalyzed biotransformation
    Authors:
    A. Sikora, D. Chełminiak-Dudkiewiczb, T. Siódmiak, A. Tarczykowskaa, W.D. Sroka, M. Ziegler-Borowska, M.P. Marszałł
    Academic press:
    Journal of Molecular Catalysis B: Enzymatic (rok: 2016, tom: 134, strony: 43-50), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.molcatb.2016.09.017 - link to the publication

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