Synthesis, characteristics and activity of biopolymer-based modified magnetic nanoparticles as potential carriers for enzymes in synthesis of beta-adrenolytic drugs
2014/15/B/NZ7/00972
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
- ST8_8: Inżynieria materiałowa (biomateriały, metale, ceramika, polimery, kompozyty)
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny
Voivodeship: kujawsko-pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
OPUS 8 – announced on 2014-09-15
- Amount awarded
- 887 875 PLN
- Project start date
- 2015-07-14
- Project end date
- 2018-07-13
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Aparat do pomiaru wielkości oraz potencjału zeta nanocząstek. Cost: 160 000 PLN
- Aparat do ultra wysokosprawnej chromatografii cieczowej (UHPLC). Cost: 255 000 PLN
- Waga precyzyjna. Cost: 1 715 PLN
- Wytrząsarka laboratoryjna.
- Wytsząsarka laboratoryjna z kontrolą temperatury.
Information in the final report
Publication in academic press/journals (5)
-
Enantioseparation of (RS)-atenolol with the use of lipases immobilized onto new-synthesized magnetic nanoparticles.
- Authors:
- A. Sikora, D. Chełminiak-Dudkiewicz, M. Ziegler-Borowska, M.P. Marszałł
- Academic press:
- Tetrahedron-Asymmetry (year: 2017, volume: 28, pages: 374–380), Publisher: Elsevier Ltd.
- Status:
- Published
- DOI:
- 10.1016/j.tetasy.2017.01.012 – link to the publication
-
Enantioselective acetylation of (R,S)-atenolol: The use of Candida rugosa lipases immobilized onto magnetic chitosan nanoparticles in enzyme-catalyzed biotransformation
- Authors:
- A. Sikora, D. Chełminiak-Dudkiewiczb, T. Siódmiak, A. Tarczykowskaa, W.D. Sroka, M. Ziegler-Borowska, M.P. Marszałł
- Academic press:
- Journal of Molecular Catalysis B: Enzymatic (year: 2016, volume: 134, pages: 43-50), Publisher: Elsevier B.V.
- Status:
- Published
- DOI:
- 10.1016/j.molcatb.2016.09.017 – link to the publication
-
Lipases - Valuable Biocatalysts in Kinetic Resolution of Racemates
- Authors:
- Agata Tarczykowska, Adam Sikora and Michal Piotr Marszall
- Academic press:
- Mini-Reviews in Organic Chemistry (year: 2018, volume: 15(5), pages: 374-381), Publisher: Bentham
- Status:
- Published
- DOI:
- 10.2174/1570193X15666171228145012 – link to the publication
-
Chitosan–Collagen Coated Magnetic Nanoparticles for Lipase Immobilization—New Type of Enzyme Friendly Polymer Shell Crosslinking with Squaric Acid
- Authors:
- M. Ziegler-Borowska, D. Chelminiak-Dudkiewicz, T. Siódmiak, A. Sikora, K. Wegrzynowska-Drzymalska, J. Skopinska-Wisniewska, H. Kaczmarek, M. P. Marszałł
- Academic press:
- Catalysts (year: 2017, volume: 7, pages: 46036), Publisher: MDPI, Basel, Switzerland
- Status:
- Published
- DOI:
- 10.3390/catal7010026 – link to the publication
-
Kinetic Resolution of (R,S)-atenolol with the Use of Lipases in Various Organic Solvents
- Authors:
- A. Sikora, W.D. Sroka, T. Siódmiak, M.P. Marszałł
- Academic press:
- Current Organic Synthesis (year: 2017, volume: 14, pages: 747-754), Publisher: Bentham Science Publishers
- Status:
- Published
- DOI:
- 10.2174/1570179414666161230120414 – link to the publication