Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of recently evolved virulence factors in control of Candida albicans biofilm development. New synthetic aromatic derivatives targeting Candida virulence.

2014/15/N/NZ6/03710

Keywords:

biofilm Candida spp. virulence factors new synthetic aromatic derivatives

Descriptors:

  • NZ6_7: Mycology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Małgorzata Gizińska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2015-08-04

Project end date (Y-m-d): 2018-08-03

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Czytnik mikropłytek (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Effect of serine protease KEX2 on Candida albicans virulence under halogenated methyl sulfones
    Authors:
    Staniszewska M.; Bondaryk M.; Kazek M.; Gliniewicz A.; Braunsdorf C.; Schaller M.; Mora-Montes H.M.; Ochal Z.
    Academic press:
    Future Microbiology (rok: 2017, tom: 12, strony: 285-306), Wydawca: Future Medicine LTD
    Status:
    Published
    DOI:
    10.2217/fmb-2016-0141 - link to the publication
  2. New 1,5 and 2,5-disubstituted tetrazoles-dependent activity towards surface barrier of Candida albicans.
    Authors:
    Staniszewska M.; Gizińska M.; Mikulak E.; Adamus K.; Koronkiewicz M.; Łukowska-Chojnacka E.
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2018, tom: 145, strony: 124-139), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2017.11.089 - link to the publication
  3. Antifungal Effect of Novel 2-Bromo-2-Chloro-2-(4-Chlorophenylsulfonyl)-1-Phenylethanone against Candida Strains.
    Authors:
    Staniszewska M.; Bondaryk M.; Wieczorek M.; Estrada-Mata E.; Mora-Montes H.M.; Ochal Z.
    Academic press:
    Frontiers in Microbiology (rok: 2016, tom: 7, strony: 1309), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01309 - link to the publication
  4. Possible role of hydrolytic enzymes (Sap, Kex2) in Candida albicans response to aromatic compounds bearing a sulfone moiety.
    Authors:
    Bondaryk M.; Grabowska-Jadach I.; Ochal Z.; Sygitowicz G.; Staniszewska M.
    Academic press:
    Chemical Papers (rok: 2016, tom: 70, strony: 1336-1350), Wydawca: De Gruyter Publisher
    Status:
    Published
    DOI:
    10.1515/chempap-2016-0072 - link to the publication
  5. Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity.
    Authors:
    Łukowska-Chojnacka E.; Mierzejewska J.; Milner-Krawczyk M.; Bondaryk M.; Staniszewska M.
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2016, tom: 24, strony: 6058-6065), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bmc.2016.09.066 - link to the publication
  6. Synthesis of novel proxyphylline derivatives with dual anti-Candida albicans and anticancer activity.
    Authors:
    Borowiecki P.; Wińska P.; Bretner M.; Gizińska M.; Koronkiewicz M.; Staniszewska M.
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2018, tom: 150, strony: 307-333), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.02.077 - link to the publication
  7. Synthesis of tetrazole derivatives bearing pyrrolidine scaffold and evaluation of their antifungal activity against Candida albicans
    Authors:
    Edyta Łukowska-Chojnacka, Anna Kowalkowska, Małgorzata Gizińska, Mirosława Koronkiewicz, Monika Staniszewska
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2019, tom: 164, strony: 106-120), Wydawca: Elsevier Masson SAS
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.12.044. - link to the publication
  8. Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds.
    Authors:
    Bondaryk M.; Staniszewska M.; Zielińska P.; Urbańczyk-Lipkowska Z.
    Academic press:
    Journal of Fungi (rok: 2017, tom: 3, strony: 46), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jof3030046 - link to the publication
  9. New trends in the search for alternative antifungal therapies | [Nowe trendy w poszukiwaniu alternatywnych terapii przeciwgrzybiczych]
    Authors:
    Małgorzata Gizińska, Weronika Pytlak, Magdalena Lis, Beata Gad, Monika Staniszewska
    Academic press:
    Pediatr Med Rodz (rok: 2019, tom: 15 (1), strony: 45642), Wydawca: Medical Communications Sp. z o.o.
    Status:
    Published
    DOI:
    10.15557/PiMR.2019.0002 - link to the publication
  10. Role of Virulence Determinants in Candida albicans' Resistance to Novel 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone.
    Authors:
    Staniszewska M.; Bondaryk M.; Ochal Z.
    Academic press:
    Journal of Fungi (rok: 2017, tom: 3, strony: 32), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jof3030032 - link to the publication

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