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The role of recently evolved virulence factors in control of Candida albicans biofilm development. New synthetic aromatic derivatives targeting Candida virulence.

2014/15/N/NZ6/03710

Keywords

Descriptors

  • NZ6_7: Mykologia

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Małgorzata Gizińska

Number of co-investigators in the project: 2

Call

PRELUDIUM 8 – announced on 2014-09-15

Amount awarded
150 000 PLN
Project start date
2015-08-04
Project end date
2018-08-03
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Czytnik mikropłytek. Cost: 45 000 PLN

Information in the final report

Publication in academic press/journals (10)

  1. Antifungal Effect of Novel 2-Bromo-2-Chloro-2-(4-Chlorophenylsulfonyl)-1-Phenylethanone against Candida Strains.

    Authors:
    Staniszewska M.; Bondaryk M.; Wieczorek M.; Estrada-Mata E.; Mora-Montes H.M.; Ochal Z.
    Academic press:
    Frontiers in Microbiology (year: 2016, volume: 7, pages: 1309), Publisher: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01309 – link to the publication

  2. New trends in the search for alternative antifungal therapies | [Nowe trendy w poszukiwaniu alternatywnych terapii przeciwgrzybiczych]

    Authors:
    Małgorzata Gizińska, Weronika Pytlak, Magdalena Lis, Beata Gad, Monika Staniszewska
    Academic press:
    Pediatr Med Rodz (year: 2019, volume: 15 (1), pages: 46372), Publisher: Medical Communications Sp. z o.o.
    Status:
    Published
    DOI:
    10.15557/PiMR.2019.0002 – link to the publication

  3. New 1,5 and 2,5-disubstituted tetrazoles-dependent activity towards surface barrier of Candida albicans.

    Authors:
    Staniszewska M.; Gizińska M.; Mikulak E.; Adamus K.; Koronkiewicz M.; Łukowska-Chojnacka E.
    Academic press:
    European Journal of Medicinal Chemistry (year: 2018, volume: 145, pages: 124-139), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2017.11.089 – link to the publication

  4. Possible role of hydrolytic enzymes (Sap, Kex2) in Candida albicans response to aromatic compounds bearing a sulfone moiety.

    Authors:
    Bondaryk M.; Grabowska-Jadach I.; Ochal Z.; Sygitowicz G.; Staniszewska M.
    Academic press:
    Chemical Papers (year: 2016, volume: 70, pages: 1336-1350), Publisher: De Gruyter Publisher
    Status:
    Published
    DOI:
    10.1515/chempap-2016-0072 – link to the publication

  5. Synthesis of tetrazole derivatives bearing pyrrolidine scaffold and evaluation of their antifungal activity against Candida albicans

    Authors:
    Edyta Łukowska-Chojnacka, Anna Kowalkowska, Małgorzata Gizińska, Mirosława Koronkiewicz, Monika Staniszewska
    Academic press:
    European Journal of Medicinal Chemistry (year: 2019, volume: 164, pages: 106-120), Publisher: Elsevier Masson SAS
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.12.044. – link to the publication

  6. Synthesis of novel proxyphylline derivatives with dual anti-Candida albicans and anticancer activity.

    Authors:
    Borowiecki P.; Wińska P.; Bretner M.; Gizińska M.; Koronkiewicz M.; Staniszewska M.
    Academic press:
    European Journal of Medicinal Chemistry (year: 2018, volume: 150, pages: 307-333), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2018.02.077 – link to the publication

  7. Effect of serine protease KEX2 on Candida albicans virulence under halogenated methyl sulfones

    Authors:
    Staniszewska M.; Bondaryk M.; Kazek M.; Gliniewicz A.; Braunsdorf C.; Schaller M.; Mora-Montes H.M.; Ochal Z.
    Academic press:
    Future Microbiology (year: 2017, volume: 12, pages: 285-306), Publisher: Future Medicine LTD
    Status:
    Published
    DOI:
    10.2217/fmb-2016-0141 – link to the publication

  8. Synthesis of novel tetrazole derivatives and evaluation of their antifungal activity.

    Authors:
    Łukowska-Chojnacka E.; Mierzejewska J.; Milner-Krawczyk M.; Bondaryk M.; Staniszewska M.
    Academic press:
    Bioorganic & Medicinal Chemistry (year: 2016, volume: 24, pages: 6058-6065), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bmc.2016.09.066 – link to the publication

  9. Role of Virulence Determinants in Candida albicans' Resistance to Novel 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone.

    Authors:
    Staniszewska M.; Bondaryk M.; Ochal Z.
    Academic press:
    Journal of Fungi (year: 2017, volume: 3, pages: 32), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jof3030032 – link to the publication

  10. Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds.

    Authors:
    Bondaryk M.; Staniszewska M.; Zielińska P.; Urbańczyk-Lipkowska Z.
    Academic press:
    Journal of Fungi (year: 2017, volume: 3, pages: 46), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jof3030046 – link to the publication

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