Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Application of SELEX methodology for selection of aptamers as research and diagnostic tools to study and potentially treat periodontitis

2014/15/D/NZ6/02546

Keywords:

periodontitis secretion system aptamers

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology
  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Danuta Mizgalska 

Number of co-investigators in the project: 3

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 457 300 PLN

Project start date (Y-m-d): 2015-07-24

Project end date (Y-m-d): 2021-07-23

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. mieszadło hematologiczne.
  2. komputer niestacjonarny typu laptop.
  3. zestaw do elekroforezy poliakrylamidowej i elektrotransferu (6 000 PLN)
  4. pipetor.
  5. separator magnetyczny (2 000 PLN)
  6. termoblok z mieszaniem (10 000 PLN)
  7. zestaw pipet laboratoryjnych (2 500 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. In vivo expression of proteases and protease inhibitor, a serpin, by periodontal pathogens at teeth and implants.
    Authors:
    Eckert M, Mizgalska D, Sculean A, Potempa J, Stavropoulos A, Eick S.
    Academic press:
    molecular oral microbiology (rok: 2018, tom: 33, strony: 240-248), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/omi.12220. - link to the publication
  2. Screening and characterization of aptamers recognizing the periodontal pathogen Tannerella forsythia
    Authors:
    Mizgalska, Danuta; Malicki, Stanisław; Golda, Anna; Chruscicka-Smaga, Barbara; Potempa, Jan
    Academic press:
    FEBS Open Bio (rok: 2024, tom: brak, strony: brak), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1002/2211-5463.13772 - link to the publication
  3. The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates.
    Authors:
    Bochtler M, Mizgalska D, Veillard F, Nowak ML, Houston J, Veith P, Reynolds EC, Potempa J
    Academic press:
    Frontières in Microbiology (rok: 2018, tom: 9, strony: 230), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2018.00230 - link to the publication
  4. Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the P. gingivalis Type-IX Secretion System.
    Authors:
    Danuta Mizgalska, Theodoros Goulas , Arturo Rodríguez-Banqueri , Florian Veillard , Mariusz Madej , Ewelina Malecka , Katarzyna Szczesniak , Miroslaw Ksiazek , Magda Widziołek , Tibisay Guevara , Ulrich Eckhard , Maria Solà , Jan Potempa , F. Xavier Gomis-Rüth
    Academic press:
    PNAS (rok: 2021, tom: 118, strony: 45301), Wydawca: National Academy of Sciences of the United States of America
    Status:
    Published
    DOI:
    10.1073/pnas.2103573118 - link to the publication
  5. Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis.
    Authors:
    Veillard F, Sztukowska M, Nowakowska Z, Mizgalska D, Thøgersen IB, Enghild JJ, Bogyo M, Potempa B, Nguyen KA, Potempa J.
    Academic press:
    Biochimie (rok: 2019, tom: 166, strony: 161-172), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biochi.2019.06.010 - link to the publication
  6. Adhesion of Porphyromonas gingivalis and Tannerella forsythia to dentin and titanium with sandblasted and acid etched surface coated with serum and serum proteins – An in vitro study
    Authors:
    Sigrun Eick, Christian Kindblom, Danuta Mizgalska, Anna Magdoń, Karolina Jurczyk, Anton Sculean, Andreas Stavropoulos
    Academic press:
    ARCHIVES OF ORAL BIOLOGY (rok: 2017, tom: 292/14, strony: 5724-5735), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.archoralbio.2016.11.001 - link to the publication
  7. Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis
    Authors:
    Anna M. Lasica, Theodoros Goulas, Danuta Mizgalska, Xiaoyan Zhou, Iñaki de Diego, Mirosław Ksiazek, Mariusz Madej, Yonghua Guo, Tibisay Guevara, Magdalena Nowak, Barbara Potempa, Apoorv Goel, Maryta Sztukowska, Apurva T. Prabhakar, Monika Bzowska, Magdalena Widziolek, Ida B. Thøgersen, Jan J. Enghild, Mary Simonian, Arkadiusz W. Kulczyk, Ky-Anh Nguyen, Jan Potempa, F. Xavier Gomis-Rüth
    Academic press:
    Scientific Reports (rok: 2016, tom: brak, strony: brak), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep37708 - link to the publication

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