Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulation of metabolic processes of contractile proteins in heart subjected to oxidative stress.

2014/15/B/NZ3/04865

Keywords:

ischaemia/hypoxia reperfusion/reoxygenation cardiomyocytes MMP-2 post-translational modyfications

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grzegorz Sawicki 

Number of co-investigators in the project: 4

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 057 050 PLN

Project start date (Y-m-d): 2015-07-15

Project end date (Y-m-d): 2019-07-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Moleculra Imager Chemi DocXRs+system with ImageLab 2.0 software, PC, 220V.
  2. Notebook.
  3. System real-time do badania kurczliwości kardiomiocytów (362 850 PLN)
  4. Graphpad (oprogramowanie).
  5. MS Office 2016.
  6. MS Office Standard 2013.
  7. Łaźnia wodna z systemem do cyrkulacji wody z wyposażeniem.
  8. Łaźnia wodna z wytrząsaniem wraz z wyposażeniem.
  9. Drukarka.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. A drug cocktail for protecting against ischemia-reperfusion injury
    Authors:
    ANNA KRZYWONOS-ZAWADZKA, MIECZYSŁAW WOŹNIAK, GRZEGORZ SAWICKI, [AUT. KORESP.] IWONA BIL-LULA
    Academic press:
    Frontiers in Bioscience-Landmark (rok: 2020, tom: 25, strony: 722-735), Wydawca: BRI
    Status:
    Published
    DOI:
    10.2741/4831 - link to the publication
  2. L-NAME improves doxycycline and ML-7 cardioprotection from oxidative stress
    Authors:
    Iwona Bil-Lula, Anna Krzywonos –Zawadzka, Jolanta Sawicka, Dariusz Bialy, Magdalena Wawrzynska, Mieczyslaw Wozniak, Grzegorz Sawicki
    Academic press:
    Frontiers in Bioscience (rok: 2018, tom: 23, strony: 298-309), Wydawca: Frontiers in Bioscience
    Status:
    Published
    DOI:
    10.2741/4592. - link to the publication
  3. Multidrug prevention or therapy of ischemia-reperfusion injury of the heart- mini review.
    Authors:
    Anna Krzywonos-Zawadzka, Aleksandra Franczak, Grzegorz Sawicki, Mieczysław Woźniak, Iwona Bil-Lula
    Academic press:
    Environmental Toxicology and Pharmacology (rok: 2017, tom: 55, strony: 55-59), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.etap.2017.08.004 - link to the publication
  1. Co-administration of low concentrations of matrix metalloproteinase 2, myosin light chain kinase and nitric oxide synthase inhibitors protects heart from ischemia/reperfusion injury
    Authors:
    I. Bil-Lula, G. Sawicki, M. Wozniak, A. Krzywonos-Zawadzka,
    Conference:
    European Society of Cardiology Congress 2017 (rok: 2017, ), Wydawca: Oxford Academic, Eur.Heart J. 2017 Vol.38 suppl.1; s.1194-1195 poz.P5565
    Data:
    konferencja 26-30.08.2017
    Status:
    Published
    DOI:
    link to the publication
  2. An association between MMP-2, MMP-9, TIMP-4 and stable coronary artery disease, hypertension and diabetes
    Authors:
    Marta Banaszkiewicz, Wiktor Kuliczkowski, Iwona Bil-Lula
    Conference:
    3rdWroclaw Scientific Meetings (rok: 2019, ), Wydawca: Wydawnictwo Naukowe TYGIEL sp. z o.o.
    Data:
    konferencja 01-02.03.2019
    Status:
    Published
    DOI:
    link to the publication
  3. Administration of exogenous iNOS inhibitor protects from ischemia/reperfusion heart injury in rat model
    Authors:
    Anna Krzywonos-Zawadzka, Aleksandra Franczak, Grzegorz Sawicki, Agnieszka Olejnik, Iwona Bil-Lula
    Conference:
    3rd Wroclaw Scientific Meetings (rok: 2019, ), Wydawca: Wydawnictwo Naukowe TYGIEL sp. z o.o.
    Data:
    konferencja 1-2.03.2019
    Status:
    Published
    DOI:
    link to the publication
  4. Mixture of MMP-2, MLCK and iNOS inhibitors protects from I/R heart injury in isolated rat heart model
    Authors:
    Anna Krzywonos-Zawadzka, Aleksandra Franczak, Grzegorz Sawicki, Agnieszka Olejnik, Iwona Bil-Lula
    Conference:
    3rd Wroclaw Scientific Meetings (rok: 2019, ), Wydawca: Wydawnictwo Naukowe TYGIEL sp. z o.o.,
    Data:
    konferencja 01-02.03.2019
    Status:
    Published
    DOI:
    link to the publication

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