Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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On the role of melanogenesis in regulation of melanoma behavior: clinical implication in stage 3 and 4

2014/15/B/NZ4/00751

Keywords:

melanoma melanogenesis prognostic factors immune phenotype

Descriptors:

  • NZ4_5: Anatomical pathology
  • NZ3_1: Cell biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Biologii i Ochrony Środowiska

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Brożyna 

Number of co-investigators in the project: 5

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 471 378 PLN

Project start date (Y-m-d): 2015-08-04

Project end date (Y-m-d): 2019-08-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Automatyczny licznik komórek (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (13)
  1. Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management
    Authors:
    Andrzej T Slominski, Anna A Brożyna, Michal A Zmijewski, Wojciech Jóźwicki, Anton M Jetten, Rebecca S Mason, Robert C Tuckey, Craig A Elmets
    Academic press:
    Laboratory Investigation (rok: 2017, tom: 97(6), strony: 706-724), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/labinvest.2017.3 - link to the publication
  2. Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic, but not melanotic melanoma cells
    Authors:
    Małgorzata Pawlikowska, Jakub Piotrowski, Tomasz Jędrzejewski, , Wiesław Kozak, Andrzej T. Slominski, Anna A. Brożyna
    Academic press:
    Phytotherapy Research (rok: 2020, tom: 34 (1), strony: 173-183), Wydawca: John Wiley & Sons Ltd
    Status:
    Accepted for publication
    DOI:
    10.1002/ptr.6513 - link to the publication
  3. Pigmentation levels affect melanoma responses to Coriolus versicolor-derived protein-bound polysaccharides and play a crucial role in melanoma-mononuclear cells crosstalk
    Authors:
    Pawlikowska Malgorzata, Jędrzejewski Tomasz, Slominski Andrzej T, Brożyna Anna A** and Wrotek Sylwia**; ** Equal senior authors
    Academic press:
    Int J Mol Sci (rok: 2021, tom: nie dotyczy, strony: nie dotyczy), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    nnie - link to the publication
  4. Relevance of Vitamin D in Melanoma Development, Progression and Therapy
    Authors:
    Anna A. Brożyna, Robert M. Hoffman, Andrzej T. Slominski
    Academic press:
    Anticancer Rersearch (rok: 2020, tom: 40 (1), strony: 473–489), Wydawca: International Institute of Anticancer Research (IIAR)
    Status:
    Published
    DOI:
    10.21873/anticanres.13976 - link to the publication
  5. Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials
    Authors:
    Martyna Śniegocka, Ewa Podgórska, Przemysław M. Płonka, Martyna Elas, Bożena Romanowska-Dixon, Małgorzata Szczygieł, Michał A. Żmijewski, Mirosława Cichorek, Anna Markiewicz, Anna A. Brożyna, Andrzej T. Słominski, Krystyna Urbańska
    Academic press:
    Int J Mol Sci (rok: 2018, tom: 19 (4), strony: 1048), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19041048 - link to the publication
  6. CKS1 expression in melanocytic nevi and melanoma
    Authors:
    Brożyna AA, Aplin A, Cohen C, Carlson G, Page AJ, Murphy M, Slominski AT, Carlson JA
    Academic press:
    Oncotarget (rok: 2017, tom: 9(3), strony: 4173-4187), Wydawca: Imact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.23648 - link to the publication
  7. Melanin content in melanoma metastases affects the outcome of radiotherapy
    Authors:
    Anna A. Brożyna, Wojciech Jóźwicki, Krzysztof Roszkowski, Jan Filipiak, Andrzej T. Slominski
    Academic press:
    Oncotarget (rok: 2016, tom: 7 (14), strony: 17844-53), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.7528 - link to the publication
  8. On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas
    Authors:
    Brożyna AA, Jóźwicki W, Jetten AM, Slominski AT
    Academic press:
    Experimental Dermatology (rok: 2019, tom: 28 (9), strony: 1036-1043), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1111/exd.14002 - link to the publication
  9. Protein-Bound Polysaccharides from Coriolus Versicolor Induce RIPK1/RIPK3/ MLKL-Mediated Necroptosis in ER-Positive Breast Cancer and Amelanotic Melanoma Cells
    Authors:
    Małgorzata Pawlikowska Tomasz Jędrzejewski Anna A. Brożyna Sylwia Wrotek
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2020, tom: 54, strony: 591-604), Wydawca: Cell Physiol Biochem Press GmbH&Co. KG
    Status:
    Published
    DOI:
    10.33594/00000024 - link to the publication
  10. Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels
    Authors:
    Markiewicz A, Brożyna AA, Podgórska E, Elas M, Urbańska K, Jetten AM, Slominski AT, Jóźwicki W, Orłowska-Heitzman J, Dyduch G, Romanowska-Dixon B.
    Academic press:
    Scientific Reports (rok: 2019, tom: 6,72361111111111, strony: 45304), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-45161-8. - link to the publication
  11. On the role of classical and novel forms of vitamin D in melanoma progression and management
    Authors:
    Slominski AT, Brożyna AA, Skobowiat C, Zmijewski MA, Kim TK, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Li W, Hoffman RM, Tuckey RC
    Academic press:
    The Journal of Steroid Biochemistry and Molecular Biology (rok: 2018, tom: 177, strony: 159-170), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2017.06.013 - link to the publication
  12. RORα and RORγ expression inversely correlates with human melanoma progression
    Authors:
    Brożyna AA, Jóźwicki W, Skobowiat C, Jetten A, Slominski AT.
    Academic press:
    Oncotarget (rok: 2016, tom: 7(39), strony: 63261-63282), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.11211 - link to the publication
  13. Vitamin D and melanoma
    Authors:
    Anna A. Brożyna
    Academic press:
    Standardy Med. Pediatr. (rok: 2015, tom: 12 (5), strony: 791-794), Wydawca: Media-Press Sp. z.o.o.
    Status:
    Published
    DOI:
    brak - link to the publication

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