Projects search

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease.

Authors:

Teixeira J, Chavarria D, Borges F, Wojtczak L, Wieckowski MR, Karkucińska-Wieckowska A, Oliveira PJ

Academic press:

Current Medicinal Chemistry (year: 2019, volume: 26(19), pages: 3376-3406), Publisher: Bentham Science Publishers

Status:

Published

DOI:

10.2174/0929867324666170529101810 – link to the publication

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles.

Authors:

Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L.

Academic press:

Nature Reviews Cardiology (year: 2019, volume: 16(1), pages: 33-55), Publisher: Springer Nature

Status:

Published

DOI:

10.1038/s41569-018-0074-0 – link to the publication

A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients

Authors:

Giampaolo Morciano, Gaia Pedriali, Massimo Bonora, Rita Pavasini, Elisa Mikus, Simone Calvi, Matteo Bovolenta, Magdalena Lebiedzinska-Arciszewska, Mirko Pinotti, Alberto Albertini, Mariusz R Wieckowski, Carlotta Giorgi, Roberto Ferrari, Lorenzo Galluzzi, Gianluca Campo, Paolo Pinton

Academic press:

Cell Reports (year: 2021, volume: 35(2), pages: 46044), Publisher: Cell Press

Status:

Published

DOI:

10.1016/j.celrep.2021.108983 – link to the publication

Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques.

Authors:

Bonora M, Morganti C, Morciano G, Giorgi C, Wieckowski MR, Pinton P

Academic press:

Nature Protocols (year: 2016, volume: 11 (6), pages: 1067-1080), Publisher: Macmillan Publishers Limited, part of Springer Nature

Status:

Published

DOI:

10.1038/nprot.2016.064 – link to the publication

Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation.

Authors:

Bonora M, Morganti C, Morciano G, Pedriali G, Lebiedzinska-Arciszewska M, Aquila G, Giorgi C, Rizzo P, Campo G, Ferrari R, Kroemer G, Wieckowski MR, Galluzzi L, Pinton P

Academic press:

EMBO Reports (year: 2017, volume: 18(7), pages: 1077-1089), Publisher: EMBOpress

Status:

Published

DOI:

10.15252/embr.201643602 – link to the publication

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure.

Authors:

Jędrzej Szymański, Justyna Janikiewicz, Bernadeta Michalska, Paulina Patalas-Krawczyk, Mariasole Perrone, Wiesław Ziółkowski, Jerzy Duszynski, Paolo Pinton, Agnieszka Dobrzyń and Mariusz R. Wieckowski

Academic press:

International Journal of Molecular Sciences (year: 2017, volume: 18(7), pages: 46078), Publisher: MDPI

Status:

Published

DOI:

10.3390/ijms18071576 – link to the publication

Mitochondrial Reactive Oxigen Species and inflammation: molecular mechanisms, diseases and promising therapies.

Authors:

Alessandro Rimessi, Maurizio Previati, Federica Nigro, Mariusz R. Wieckowski and Paolo Pinton

Academic press:

The International Journal of Biochemistry & Cell Biology (year: 2016, volume: 81, pages: 281-293), Publisher: ELSEVIER

Status:

Published

DOI:

10.1016/j.biocel.2016.06.015 – link to the publication

Quantifying ROS levels using CM-H2DCFDA and HyPer

Authors:

Monika Oparka, Jarosław Walczak, Dominika Malinska, Lisanne M.P.E. van Oppen, Joanna Szczepanowska, Werner J.H. Koopman and Mariusz R. Wieckowski

Academic press:

Methods (year: 2016, volume: 109, pages: 46092), Publisher: ELSEVIER

Status:

Published

DOI:

10.1016/j.ymeth.2016.06.008 – link to the publication

Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice

Authors:

Flis DJ, Dzik K, Kaczor JJ, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W.

Academic press:

Oxidative Medicine and Cellular Longevity (year: 2018, volume: eCollection, pages: 46034), Publisher: Hindawi

Status:

Published

DOI:

10.1155/2018/5940748 – link to the publication

Mitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington's disease patients

Authors:

Jędrak P, Mozolewski P, Węgrzyn G, Więckowski MR

Academic press:

Metabolic Brain Disease (year: 2018, volume: 33(6), pages: 2005-2017), Publisher: Springer

Status:

Published

DOI:

10.1007/s11011-018-0308-1 – link to the publication

Modulation of mitochondrial dysfunction-related oxidative stress in fibroblasts of patients with Leigh syndrome by inhibition of prooxidative p66Shc pathway.

Authors:

Wojtala A, Karkucinska-Wieckowska A, Sardao VA, Szczepanowska J, Kowalski P, Pronicki M, Duszynski J, Wieckowski MR.

Academic press:

Mitochondrion (year: 2017, volume: 37, pages: 62-79), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.mito.2017.07.002 – link to the publication

Discovery of novel 1,3,8-triazaspiro[4.5]decane derivatives that target the c subunit of F1/FO-adenosine triphosphate (ATP) synthase for the treatment of reperfusion damage in myocardial infarction

Authors:

Morciano G, Preti D, Pedriali G, Aquila G, Missiroli S, Fantinati A, Caroccia N, Pacifico S, Bonora M, Talarico A, Morganti C, Rizzo P, Ferrari R, Wieckowski MR, Campo G, Giorgi C, Trapella C, Pinton P.

Academic press:

Journal of Medicinal Chemistry (year: 2018, volume: 61(16), pages: 7131-7143.), Publisher: ACS

Status:

Published

DOI:

10.1021/acs.jmedchem.8b00278 – link to the publication

NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4-/- mice and Leigh syndrome patients: A stabilizing role for NDUFAF2.

Authors:

Adjobo-Hermans MJW, de Haas R, Willems PHGM, Wojtala A, van Emst-de Vries SE, Wagenaars JA, van den Brand M, Rodenburg RJ, Smeitink JAM, Nijtmans LG, Sazanov LA, Wieckowski MR $, Koopman WJH. $ ($ co-corresponding authors)

Academic press:

Biochim Biophys Acta - Bioenergetics (year: 2020, volume: 1861, pages: 46033), Publisher: Elsevier

Status:

Published

DOI:

10.1016/j.bbabio.2020.148213 – link to the publication

Recovering mitochondrial function in patients' fibroblasts

Authors:

Mariusz R. Wieckowski, Alberto Danese, Giampaolo Morciano, Maciej Pronicki, Jerzy Duszynski, Paolo Pinton and Agnieszka Karkucinska-Wieckowska

Book:

Mitochondrial Biology and Experimental Therapeutics (year: 2018, volume: brak informacji, pages: 359-378), Publisher: Springer International Publishing

Status:

Published

Mitochondria in Multiple Sclerosis: Molecular Mechanisms of Pathogenesis

Authors:

S.Patergnani, V.Fossati, M.Bonora, Giorgi, Marchi, Missiroli, T.Rusielewicz, M.R.Wieckowski, P.Pinton

Book:

International Review of Cell and Molecular Biology (year: 2017, volume: 328, pages: 49-103), Publisher: Elsevier

Status:

Published

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

Authors:

Giorgi C, Marchi S, Simoes ICM, Ren Z, Morciano G, Perrone M, Patalas-Krawczyk P, Borchard S, Jędrak P, Pierzynowska K, Szymański J, Wang DQ, Portincasa P, Węgrzyn G, Zischka H, Dobrzyn P, Bonora M, Duszynski J, Rimessi A, Karkucinska-Wieckowska A, Dobrzyn A, Szabadkai G, Zavan B, Oliveira PJ, Sardao VA, Pinton P, Wieckowski MR.

Book:

International Review of Cell and Molecular Biology (year: 2018, volume: 340, pages: 209-344), Publisher: ELSEVIER

Status:

Published