Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Significance of SHH signaling pathway in pathogenesis and progression of pediatric germ cell tumors.

2014/15/B/NZ4/04855

Keywords:

germ cell tumors SHH pathway molecular alterations gene expression signaling pathways histopathology immunophenotype pediatric oncology mutations

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ3_7: Signal transduction
  • NZ4_5: Anatomical pathology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Nauk o Zdrowiu z Instytutem Medycyny Morskiej i Tropikalnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Iżycka-Świeszewska 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 712 180 PLN

Project start date (Y-m-d): 2015-07-16

Project end date (Y-m-d): 2020-07-15

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. wirówka laboratoryjna z funkcją tworzenia cytobloków (35 000 PLN)
  2. laptop.
  3. mikroskop badawczy świetlny wysokiej klasy, z cyfrowym analizatorem obrazu i aparatem fotograficznym wysokiej rozdzielczości (125 000 PLN)
  4. komora do badań immunohistochemicznych.
  5. mikrotom rotacyjny automatyczny (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Dysgerminoma with a somatic exon 17 KIT mutation and SHH pathway activation in a girl with Turner syndrome.
    Authors:
    Gawrychowska A, Iżycka-Świeszewska E, Lipska-Ziętkiewicz B, Kuleszo D, Bautembach-Minkowska J, Łosin M, Stefanowicz J
    Academic press:
    Diagnostics (rok: 2020, tom: 10(12), strony: 1067), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/diagnostics10121067 - link to the publication
  2. Endometrial glial polyp and peritoneal gliomatosis - the neuropathological lesions in gynecological biopsy
    Authors:
    Czarnota K, Goertz S, Gulczynski J, Hermann-Okoniewska B, Czauderna P, Adamkiewicz-Drozynska E, Izycka-Swieszewska E
    Academic press:
    Clinical Neuropathology (rok: 2019, tom: 38, strony: 174-179), Wydawca: Dustri Verlag
    Status:
    Published
    DOI:
    10.5414/NP301163 - link to the publication
  3. Hedgehog signaling network gene status analysis in pediatric intracranial germ cell tumors.
    Authors:
    Kuleszo D, Lipska-Ziętkiewicz B, Koczkowska M, Zakrzewski K, Grajkowska W, Roszkowski M, Dembowska-Bagińska B, Czarnota K, Adamkiewicz-Drożyńska E, Iżycka-Świeszewska E
    Academic press:
    Folia Neuropathologica (rok: 2019, tom: 57, strony: 227-238), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2019.88451 - link to the publication
  4. Comparative genomic analysis of intracranial germ cell tumors – the preliminary study focused on Sonic Hedgehog signaling pathway.
    Authors:
    Kuleszo D, Koczkowska M, Lipska-Ziętkiewicz B, Grajkowska W, Adamkiewicz-Drożyńska E, Dembowska-Bagińska B, Ciałkowski M, Iżycka-Świeszewska E
    Academic press:
    Contemporary Oncology (rok: 2017, tom: 21, strony: 279-284), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/wo.2017.72390 - link to the publication
  5. Expression of BARD1 β Isoform in Selected Pediatric Tumors
    Authors:
    Jasiak A, Krawczynska N, Iliszko M, Czarnota K, Buczkowski K, Stefanowicz J, Adamkiewicz-Drozynska E, Cichosz G, Izycka-Swieszewska E
    Academic press:
    Genes (rok: 2021, tom: 12(2), strony: 168), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes12020168 - link to the publication