Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Silver(I) complexes of imidazole and pyridine derivatives - synthesis, structural characterization, antimicrobial and cytotoxic activity.

2014/15/B/NZ7/00944

Keywords:

silver(I) complexes imidazole and pyridine derivatives synthesis spectroscopic and spectrometric identification crystal structure antibacterial activity antifungal activity cytotoxic activity

Descriptors:

  • NZ7_14:
  • ST5_14:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Katedra Chemii Medycznej; Zakład Chemii Bionieorganizcnej

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Justyn Ochocki 

Number of co-investigators in the project: 9

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 846 070 PLN

Project start date (Y-m-d): 2015-07-20

Project end date (Y-m-d): 2022-07-19

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komora klimatyczna (65 000 PLN)
  2. waga analityczna (8 500 PLN)
  3. mieszadło magnetyczne z regulatorem temperatury (7 000 PLN)
  4. pompa próżniowa membranowa (13 500 PLN)
  5. mieszadło magnetyczne z regulatorem temperatury.
  6. wyparka rotacyjna z kontrolerem próżni (32 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (2)
  1. Clinical Application and Efficacy of Silver Drug in Ophthalmology: A Literature Review and New Formulation of EYE Drops with Drug Silver (I) Complex of Metronidazole with Improved Dosage Form
    Authors:
    Arleta Waszczykowska, Dominik Żyro, Justyn Ochocki, Piotr Jurowski
    Academic press:
    Biomedicines (rok: 2021, tom: 9(2), strony: 45669), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biomedicines9020210 - link to the publication
  2. Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3
    Authors:
    Urszula Kalinowska-Lis , Aleksandra Felczak , Lilianna Chęcińska, Ilona Szabłowska-Gadomska, Emila Patyna, Maciej Małecki, Katarzyna Lisowska and Justyn Ochocki
    Academic press:
    molecules (rok: 2016, tom: 21, strony: 45671), Wydawca: MDPI.com, Basel
    Status:
    Published
    DOI:
    10.3390/molecules21020087 - link to the publication
  3. 10.Multifunctional Silver(I) Complexes with Metronidazole Drug Reveal Antimicrobial Properties and Antitumor Activity against Human Hepatoma and Colorectal Adenocarcinoma Cells.
    Authors:
    D. Żyro, L. Radko, A. Śliwińska, L. Chęcińska, J. Kusz, I. Korona-Głowniak, A. Przekora, M. Wójcik, A. Posyniak, J. Ochocki,
    Academic press:
    Cancers (rok: 2022, tom: 14, 900, strony: 45681), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14040900 - link to the publication
  4. Silver(I) Complexes of the Pharmaceutical Agents Metronidazole and 4-Hydroxymethylpyridine: Comparison of Cytotoxic Profile for Potential Clinical Application
    Authors:
    Lidia Radko, Sylwia Stypuła-Trębas, Andrzej Posyniak, Dominik Żyro, Justyn Ochocki
    Academic press:
    MOLECULES (rok: 2019, tom: 24(10), 1949, strony: 45669), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    24(10), - link to the publication
  5. Effect of Treatment of Silver(I) Complex of Metronidazole on Ocular Rosacea. Design and Formulation of New Silver Drug With Potent Antimicrobal Activity"
    Authors:
    Arleta Waszczykowska, Piotr Jurowski, Dominik Żyro, Justyn Ochocki
    Academic press:
    Journal of Trace Elements in Biology and Medicine (rok: 2020, tom: 61, strony: 45664), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jtemb.2020.126531 - link to the publication
  6. Effect of Treatment of Silver(I) Complex of Metronidazole on Ocular Rosacea. Design and Formulation of New Silver Drug With Potent Antimicrobal Activity"
    Authors:
    Arleta Waszczykowska, Piotr Jurowski, Dominik Żyro, Justyn Ochocki
    Academic press:
    Journal of Trace Elements in Biology and Medicine (rok: 2020, tom: 61, strony: 45664), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jtemb.2020.126531 - link to the publication
  7. Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3
    Authors:
    Urszula Kalinowska-Lis , Aleksandra Felczak , Lilianna Chęcińska, Ilona Szabłowska-Gadomska, Emila Patyna, Maciej Małecki, Katarzyna Lisowska and Justyn Ochocki
    Academic press:
    molecules (rok: 2016, tom: 21, strony: 45671), Wydawca: MDPI.com, Basel
    Status:
    Published
    DOI:
    10.3390/molecules21020087 - link to the publication
  8. Synthesis, Spectroscopy, Single-Crystal Structure Analysis and Antibacterial Activity of Two Novel Complexes of Silver(I) with Miconazole Drug
    Authors:
    Karolina Stryjska, Izabela Korona-Glowniak, Lilianna Chęcińska, Joachim Kusz, Justyn Ochocki
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22(4), strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041510 - link to the publication
  9. Stability of Metronidazole and Its Complexes with Silver(I) Salts under Various Stress Conditions
    Authors:
    Małgorzata Starek, Monika Dąbrowska, Joanna Chebda, Dominik Żyro, Justyn Ochocki
    Academic press:
    Molecules (rok: 2021, tom: 26(12), strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26123582 - link to the publication
  10. Synthesis, Spectroscopy, Single-Crystal Structure Analysis and Antibacterial Activity of Two Novel Complexes of Silver(I) with Miconazole Drug
    Authors:
    Karolina Stryjska, Izabela Korona-Glowniak, Lilianna Chęcińska, Joachim Kusz, Justyn Ochocki
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22(4), strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041510 - link to the publication
  11. Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole
    Authors:
    Karolina Stryjska, Lidia Radko, Lilianna Chęcińska, Joachim Lusz, Andrzej Posyniak, Justyn Ochocki
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, strony: 45675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21103629 - link to the publication
  12. Light Stability, Pro-Apoptotic and Genotoxic Properties of Silver (I) Complexes of Metronidazole and 4-Hydroxymethylpyridine against Pancreatic Cancer Cells In Vitro
    Authors:
    Dominik Żyro; Agnieszka Śliwińska; Izabela Szymczak-Pajor; Małgorzata Stręk; Justyn Ochocki
    Academic press:
    Cancers (rok: 2020, tom: 12, strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12123848 - link to the publication
  13. Influence of selected inorganic counter-ions on the structure and antimicrobial properties of silver(I) complexes with imidazole-containing ligands
    Authors:
    Urszula Kalinowska-Lis, Aleksandra Felczak, Lilianna Chęcińska, Magdalena Małecka, Katarzyna Lisowska and Justyn Ochocki
    Academic press:
    New J. Chem., (rok: 2016, tom: 40, strony: 694--704), Wydawca: The Royal Society of Chemistry and the Centre National de la Recherche Scientifique
    Status:
    Published
    DOI:
    10.1039/c5nj02514a - link to the publication
  14. 10.Multifunctional Silver(I) Complexes with Metronidazole Drug Reveal Antimicrobial Properties and Antitumor Activity against Human Hepatoma and Colorectal Adenocarcinoma Cells.
    Authors:
    D. Żyro, L. Radko, A. Śliwińska, L. Chęcińska, J. Kusz, I. Korona-Głowniak, A. Przekora, M. Wójcik, A. Posyniak, J. Ochocki,
    Academic press:
    Cancers (rok: 2022, tom: 14, 900, strony: 45681), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14040900 - link to the publication
  1. SYNTHESIS, SPECTROSCOPY AND BIOLOGICAL EVALUATION OF SILVER(I) COMPLEXES WITH METRONIDAZOLE. X-RAY CRYSTAL STRUCTURE OF [Ag2(MTZ)4]SO4
    Authors:
    Żyro D., Stręk M., Śliwińska A., Chęcińska L., Kusz J., Ochocki J.
    Conference:
    ІV International Scientific and Practical Conference «Medical drugs for humans. Modern issues of pharmacotherapy and prescription of medicine», dedicated to the 35th anniversary of the department of Pharmacotherapy (rok: 2020, ), Wydawca: National University of Pharmacy, Seria "Nauka"
    Data:
    konferencja 12-13 March, 2020
    Status:
    Published
  2. Prevention of the probe hole clogging up during administration of nano Ag preparations in animal models of GI diseases
    Authors:
    Krzysztof Siczek, Przemysław Kubiak, and Justyn Ochocki
    Conference:
    6th International Conference on Medicinal Chemistry (rok: 2020, ), Wydawca: mdpi
    Data:
    konferencja 1-30 November 2020
    Status:
    Published
    DOI:
    link to the publication

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