Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Identification and comprehensive classification of nucleases including human nucleases

2014/15/B/NZ1/03357

Keywords:

nucleases protein classification protein structure and function prediction distant homology detection novel nucleases human

Descriptors:

  • NZ1_4: Structural biology
  • NZ2_7: Bioinformatics
  • ST6_13: Bioinformatics, biocomputing, DNA and molecular computation

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Ginalski 

Number of co-investigators in the project: 5

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 900 820 PLN

Project start date (Y-m-d): 2015-11-02

Project end date (Y-m-d): 2019-03-22

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Information in the final report

  • Publication in academic press/journals (15)
  1. Fungal lifestyle reflected in serine protease repertoire
    Authors:
    Muszewska, A., Stepniewska-Dziubinska, M.M., Steczkiewicz, K., Pawlowska, J., Dziedzic A., Ginalski, K.
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 9147), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-09644-w - link to the publication
  2. Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy
    Authors:
    Mikula, M., Skrzypczak, M., Goryca, K., Paczkowska, K., Ledwon, J.K., Statkiewicz, M., Kulecka, M., Grzelak, M., Dabrowska, M., Kuklinska, U., Karczmarski, J., Rumienczyk, I., Jastrzebski, K., Miaczynska, M., Ginalski, K., Bomsztyk, K., Ostrowski, J.
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 10150-10164), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkw763 - link to the publication
  3. Towards engineering novel PE-based immunotoxins by targeting them to the nucleus
    Authors:
    Borowiec, M., Gorzkiewicz, M., Grzesik, J., Walczak-Drzewiecka, A., Salkowska, A., Rodakowska, E., Steczkiewicz, K., Rychlewski, L., Dastych, J., Ginalski, K.
    Academic press:
    Toxins (rok: 2016, tom: 8, strony: E321), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/toxins8110321 - link to the publication
  4. FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases
    Authors:
    Kuchta, K., Muszewska, A., Knizewski, L., Steczkiewicz, K., Wyrwicz, L.S., Pawlowski, K., Rychlewski, L., Ginalski, K.
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 3534-3548), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkw222 - link to the publication
  5. Structural, biochemical, and evolutionary characterization of glyoxylate/hydroxypyruvate reductases shows their division into two distinct subfamilies
    Authors:
    Kutner, J., Shabalin, I.G., Matelska, D., Handing, K.B., Gasiorowska, O., Sroka, P., Gorna, M.W., Ginalski, K., Wozniak, K., Minor, W.
    Academic press:
    Biochemistry (rok: 2018, tom: 57, strony: 963-977), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biochem.7b01137 - link to the publication
  6. Cut-and-paste transposons in fungi with diverse lifestyles
    Authors:
    Muszewska, A., Steczkiewicz, K., Stepniewska-Dziubinska, M., Ginalski, K.
    Academic press:
    Genome Biology and Evolution (rok: 2017, tom: 9, strony: 3463-3477), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/gbe/evx261 - link to the publication
  7. Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
    Authors:
    Shi, W., Vu, T., Boucher, D., Biernacka, A., Nde, J., Pandita, R.K., Straube, J., Boyle, G.M., Al-Ejeh, F., Nag, P., Jeffery, J., Harris, J.L., Bain, A.L., Grzelak, M., Skrzypczak, M., Mitra, A., Dojer, N., Crosetto, N., Cloonan, N., Becherel, O.J., Finnie, J., Skaar, J.R., Walkley, C.R., Pandita, T.K., Rowicka, M., Ginalski, K., Lane, S.W., Khanna, K.K.
    Academic press:
    Blood (rok: 2017, tom: 129, strony: 2479-2492), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2016-06-725093 - link to the publication
  8. Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases: 2HADH knowledgebase
    Authors:
    Matelska, D., Shabalin, I.G., Jablonska, J., Domagalski, M.J., Kutner, J., Ginalski, K., Minor, W.
    Academic press:
    BMC Evolutionary Biology (rok: 2018, tom: 18, strony: 199), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12862-018-1309-8 - link to the publication
  9. Comparative genomic analysis of Staphylococcus lugdunensis shows a closed pan-genome and multiple barriers to horizontal gene transfer
    Authors:
    Argemi, X., Matelska, D., Ginalski, K., Riegel, P., Hansmann, Y., Bloom, J., Pestel-Caron, M., Dahyot, S., Lebeurre, J., Prevost, G.
    Academic press:
    BMC Genomics (rok: 2018, tom: 19, strony: 621), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12864-018-4978-1 - link to the publication
  10. Predicting proteome dynamics using gene expression data
    Authors:
    Kuchta, K., Towpik, J., Biernacka, A., Kutner, J., Kudlicki, A., Ginalski, K., Rowicka, M.
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 13866), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-31752-4 - link to the publication
  11. Biochemical and structural bioinformatics studies of fungal CutA nucleotidyltransferases explain their unusual specificity towards CTP and increased tendency for cytidine incorporation at the 3'-terminal positions of synthesized tails
    Authors:
    Kobylecki, K., Kuchta, K., Dziembowski, A., Ginalski, K., Tomecki, R.
    Academic press:
    RNA (rok: 2017, tom: 23, strony: 1902-1926), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.117 - link to the publication
  12. Comprehensive classification of the PIN domain-like superfamily
    Authors:
    Matelska, D., Steczkiewicz, K., Ginalski, K.
    Academic press:
    Nucleic Acids Research (rok: 2017, tom: 45, strony: 6995-7020), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkx494 - link to the publication
  13. Diverse cap-binding properties of Drosophila eIF4E isoforms
    Authors:
    Zuberek, J., Kuchta, K., Hermandez, G., Sonenberg, N., Ginalski, K.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (rok: 2016, tom: 1864, strony: 1292-1303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbapap.2016.06.015 - link to the publication
  14. Phylogeny-based systematization of Arabidopsis proteins with histone H1 globular domain
    Authors:
    Kotlinski, M., Knizewski, L., Muszewska, A., Rutowicz, K., Lirski, M., Schmidt, A., Baroux, C., Ginalski, K., Jerzmanowski, A.
    Academic press:
    Plant Physiology (rok: 2017, tom: 174, strony: 27-34), Wydawca: American Society of Plant Biologists
    Status:
    Published
    DOI:
    10.1104/pp.16.00214 - link to the publication
  15. Systematic classification of the His-Me finger superfamily
    Authors:
    Jablonska, J., Matelska, D., Steczkiewicz, K., Ginalski, K.
    Academic press:
    Nucleic Acids Research (rok: 2017, tom: 45, strony: 11479-11494), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkx924 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy