Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Role of leptin in the pathogenesis of ovarian dysfunction during obesity progression

2014/15/D/NZ4/01152

Keywords:

Leptin Obesity Ovary Leptin-resistance Insulin-resistance Inflammation Cell stress

Descriptors:

  • NZ4_6:
  • NZ4_11:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Antonio Miguel Galvao 

Number of co-investigators in the project: 5

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 683 099 PLN

Project start date (Y-m-d): 2015-07-15

Project end date (Y-m-d): 2019-04-14

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (27)
  1. Leptin Resistance in the Ovary of Obese Mice is Associated with Profound Changes in the Transcriptome of Cumulus Cells
    Authors:
    Wołodko, Karolina; Walewska, Edyta; Adamowski, Marek; Castillo-Fernandez, Juan; Kelsey, Gavin; Galvão, António M.
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2020, tom: 54(3), strony: 417-437), Wydawca: Cell Physiol Biochem Press, Düsseldorf, Germany
    Status:
    Published
    DOI:
    10.33594/000000228 - link to the publication
  1. How Obesity Affects Ovarian Function and the Oocyte Epigenome - Plenary Session
    Authors:
    Galvão A, Adamowski M, Thomas K, Kelsey G.
    Conference:
    I Symposium Scientific Consortium Healthy Animal – Safe Food (rok: 2017, ), Wydawca: Consortium KNOW
    Data:
    konferencja 12th-13th June 2017
    Status:
    Published
    DOI:
    link to the publication
  2. Maternal obesity affects the oocyte epigenome in mice
    Authors:
    António Galvão, Stephen Clark, Gavin Kelsey
    Conference:
    Epigenomics of Common Diseases (rok: 2017, ), Wydawca: Welcome Genome Campus, Sanguer Institute
    Data:
    konferencja 14-17 November
    Status:
    Published
    DOI:
    link to the publication
  3. Ovarian transcription of DNMTs in different mouse obesity models
    Authors:
    Galvão A, Jura M, Wolodko M, Kelsey G.
    Conference:
    National Ovarian Workshop (rok: 2016, ), Wydawca: Cambridge university
    Data:
    konferencja 19th- 20th September
    Status:
    Published
  4. Correlation between phenotype and ovarian failure in different mice strains subjected to diet-induced obesity
    Authors:
    Galvão A, Thomas K, Jura M
    Conference:
    20th Annual Conference of European Society for Domestic Animals Reproduction (rok: 2016, ), Wydawca: Reprodution in Domestic Animals
    Data:
    konferencja 27th – 29th October
    Status:
    Published
  5. Udział leptyny w patogenezie jajnika w stanie otyłości u myszy
    Authors:
    K. Wołodko, M. Adamowski, D. Skarżyński, A.Galvao
    Conference:
    Sympozjum naukowe "Perspektywy w ochornie bioróżnorodności" (rok: 2016, ), Wydawca: IRZiBZ PAN, Olsztyn
    Data:
    konferencja 28-29.11
    Status:
    Published
  6. Leptin signaling activation mediates ovarian pathology in diet-induced obesity mice
    Authors:
    Wołodko K., Adamowski M., Skarżyński D.J., Galvao A.
    Conference:
    VIII Zjazd Towarzystwa Biologii Rozrodu [VIII Symposium of Polish Society for Reproductive Biology] (rok: 2017, ), Wydawca: Reproductive Biology
    Data:
    konferencja 7th-9th September
    Status:
    Published
  7. Maternal Obesity Modulates the Oocyte Methylome and Transcriptome
    Authors:
    Galvão A, Wolodko K, Adamowski M, Clark S, Kelsey G
    Conference:
    Society for Study of Reproduction and Fertility (rok: 2018, ), Wydawca: SSR/BOR
    Data:
    konferencja 10th – 13th July
    Status:
    Published
  8. The role of leptin signalling in ovarian pathogenesis during obesity
    Authors:
    Wolodko K, Adamowski M, Skarżyński D, Galvão A.
    Conference:
    Fertility (rok: 2017, ), Wydawca: UK
    Data:
    konferencja 5th – 7th January, 2017
    Status:
    Published
  9. Ovarian failure in diet-induced obese mice might be associated with the establishment of local leptin resistance.
    Authors:
    Galvão A, Jura M, Thomas K, Skarzynski DJ
    Conference:
    Epigenetics, Obesity and Metabolism" (rok: 2015, ), Wydawca: Welcome Genome Campus
    Data:
    konferencja 11th-14th October
    Status:
    Published
  10. Leptin Signalling Characterisation in the Ovary of Diet-Induced Obese and Pharmacologically Hyperleptinemic Mouse
    Authors:
    Wołodko K, Walewska E, Adamowski M, Galvao A
    Conference:
    Society for Study of Reproduction and Fertility (rok: 2018, ), Wydawca: SSR/BOR
    Data:
    konferencja 10th – 13th July
    Status:
    Published
  11. Udział leptyny w patogenezie jajnika w stanie otyłości u myszy
    Authors:
    K. Wołodko, M. Adamowski, D. Skarżyński, A.Galvao
    Conference:
    Sympozjum naukowe "Perspektywy w ochornie bioróżnorodności" (rok: 2016, ), Wydawca: IRZiBZ PAN, Olsztyn
    Data:
    konferencja 28-29.11
    Status:
    Published
  12. Ovarian characterization of gonadotropins and steroid hormone receptors expression in diet-induced obese mice
    Authors:
    Thomas K, Skarzynski D, Galvão A.
    Conference:
    20th Annual Conference of European Society for Domestic Animals Reproduction (rok: 2016, ), Wydawca: Rerpduction in Domestic Animals
    Data:
    konferencja 27th – 29th October
    Status:
    Published
  13. Leptin signaling activation mediates ovarian pathology in diet-induced obesity mice
    Authors:
    Wołodko K., Adamowski M., Skarżyński D.J., Galvao A.
    Conference:
    VIII Zjazd Towarzystwa Biologii Rozrodu [VIII Symposium of Polish Society for Reproductive Biology] (rok: 2017, ), Wydawca: Reproductive Biology
    Data:
    konferencja 7th-9th September
    Status:
    Published
  14. Maternal obesity affects the epigenome of oocytes and preimplantation embryos.
    Authors:
    Galvão A, Clark S, Kelsey G
    Conference:
    Advances at the interface between metabolism and epigenetics (rok: 2019, ), Wydawca: Robinson College
    Data:
    konferencja 16th-17th January
    Status:
    Published
  15. Rola inflamasomu w patogenezie dysfunkcji jajnika w stanie otyłości u myszy
    Authors:
    Adamowski M., Wołodko K., Galvao A.
    Conference:
    Perspektywy w ochronie bioróżnorodności (rok: 2016, ), Wydawca: IRZiBZ PAN
    Data:
    konferencja 28-29.11
    Status:
    Published
  16. Ovarian-specific Regulation of Inflammasome in Obese Mice
    Authors:
    Adamowski M , Wołodko K, Galvao A.
    Conference:
    Society for Study of Reproduction and Fertility (rok: 2018, ), Wydawca: SSR/BOR
    Data:
    konferencja 10th – 13th July
    Status:
    Published
  17. Nod-like receptor protein 1 and 3 are ovarian specific mediators of inflammatory response in the course of diet- induced obesity in mice
    Authors:
    Adamowski A, Jura M, Galvão A.
    Conference:
    20th Annual Conference of European Society for Domestic Animals Reproduction (rok: 2016, ), Wydawca: Reproduction in Domestic Animals
    Data:
    konferencja 27th – 29th October
    Status:
    Published
  18. Ovarian characterization of gonadotropins and steroid hormone receptors expression in diet-induced obese mice
    Authors:
    Thomas K, Skarzynski D, Galvão A.
    Conference:
    20th Annual Conference of European Society for Domestic Animals Reproduction (rok: 2016, ), Wydawca: Rerpduction in Domestic Animals
    Data:
    konferencja 27th – 29th October
    Status:
    Published
  19. Nod-like receptor protein 1 and 3 are ovarian specific mediators of inflammatory response in the course of diet- induced obesity in mice
    Authors:
    Adamowski A, Jura M, Galvão A.
    Conference:
    20th Annual Conference of European Society for Domestic Animals Reproduction (rok: 2016, ), Wydawca: Reproduction in Domestic Animals
    Data:
    konferencja 27th – 29th October
    Status:
    Published
  20. How Obesity Affects Ovarian Function and the Oocyte Epigenome - Plenary Session
    Authors:
    Galvão A, Adamowski M, Thomas K, Kelsey G.
    Conference:
    I Symposium Scientific Consortium Healthy Animal – Safe Food (rok: 2017, ), Wydawca: Consortium KNOW
    Data:
    konferencja 12th-13th June 2017
    Status:
    Published
    DOI:
    link to the publication
  21. Ovarian-specific Regulation of Inflammasome in Obese Mice
    Authors:
    Adamowski M , Wołodko K, Galvao A.
    Conference:
    Society for Study of Reproduction and Fertility (rok: 2018, ), Wydawca: SSR/BOR
    Data:
    konferencja 10th – 13th July
    Status:
    Published
  22. Maternal obesity affects the epigenome of oocytes and preimplantation embryos.
    Authors:
    Galvão A, Clark S, Kelsey G
    Conference:
    Advances at the interface between metabolism and epigenetics (rok: 2019, ), Wydawca: Robinson College
    Data:
    konferencja 16th-17th January
    Status:
    Published
  23. Ovarian transcription of DNMTs in different mouse obesity models
    Authors:
    Galvão A, Jura M, Wolodko M, Kelsey G.
    Conference:
    National Ovarian Workshop (rok: 2016, ), Wydawca: Cambridge university
    Data:
    konferencja 19th- 20th September
    Status:
    Published
  24. The role of leptin signalling in ovarian pathogenesis during obesity
    Authors:
    Wolodko K, Adamowski M, Skarżyński D, Galvão A.
    Conference:
    Fertility (rok: 2017, ), Wydawca: UK
    Data:
    konferencja 5th – 7th January, 2017
    Status:
    Published
  25. Ovarian failure in diet-induced obese mice might be associated with the establishment of local leptin resistance.
    Authors:
    Galvão A, Jura M, Thomas K, Skarzynski DJ
    Conference:
    Epigenetics, Obesity and Metabolism" (rok: 2015, ), Wydawca: Welcome Genome Campus
    Data:
    konferencja 11th-14th October
    Status:
    Published
  26. Maternal Obesity Modulates the Oocyte Methylome and Transcriptome
    Authors:
    Galvão A, Wolodko K, Adamowski M, Clark S, Kelsey G
    Conference:
    Society for Study of Reproduction and Fertility (rok: 2018, ), Wydawca: SSR/BOR
    Data:
    konferencja 10th – 13th July
    Status:
    Published
  27. Maternal obesity affects the oocyte epigenome in mice
    Authors:
    António Galvão, Stephen Clark, Gavin Kelsey
    Conference:
    Epigenomics of Common Diseases (rok: 2017, ), Wydawca: Welcome Genome Campus, Sanguer Institute
    Data:
    konferencja 14-17 November
    Status:
    Published
    DOI:
    link to the publication

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