Projects funded by the NCN
The involvement of IL-10 in the activation of the suppression mechanism utilized by myeloid-derived suppressor cells - does the elimination of IL-10 from tumor environment enhance the effectiveness of immunotherapy strategies?
2014/15/N/NZ4/04817
Keywords:
MDSC dendritic cells interleukin 10
Descriptors:
- NZ4_12: Other related subjects
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN
woj. dolnośląskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 3
Call: PRELUDIUM 8 - announced on 2014-09-15
Amount awarded: 150 000 PLN
Project start date (Y-m-d): 2015-07-13
Project end date (Y-m-d): 2019-01-12
Project duration:: 42 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (2)
- Articles in post-conference publications (5)
- Reprogramming the murine colon cancer microenvironment using lentivectors encoding shRNA against IL-10 as a component of a potent DC-based chemoimmunotherapy.Authors:Rossowska J, Anger N, Szczygieł A, Mierzejewska J, Pajtasz-Piasecka EAcademic press:Journal of Experimental & Clinical Cancer Research (rok: 2018, tom: 37, strony: 126), Wydawca: BioMed CentralStatus:PublishedDOI:10.1186/s13046-018-0799-y - link to the publication
- Komórki supresorowe pochodzenia mieloidalnego jako potencjalny cel terapii przeciwnowotworowychAuthors:Anger N, Rossowska JAcademic press:Postępy Higieny i Medycyny Doświadczalnej (rok: 2018, tom: 72, strony: 1179-1198), Wydawca: Index Copernicus InternationalStatus:PublishedDOI:10.5604/01.3001.0012.8267 - link to the publication
- Bone marrow cells in the study of the role of interleukin 10 in myeloid-derived suppressor cell biologyAuthors:Anger N, Rossowska JConference:Bone Marrow Transplantation – Much More Then Haematopoietic Tissue Reconstitution (rok: 2017, ), Wydawca: nie dotyczyData:konferencja 18-20.12.2017Status:Published
- Evaluation of local immune response after silencing of IL-10 or IL-10R expression in MC38 tumorsAuthors:Anger N, Szczygieł A, Węgierek K, Mierzejewska J, Napierała M, Pajtasz-Piasecka E, Rossowska JConference:5th European Congress of Immunology (rok: 2018, ), Wydawca: Wiener Medizinische Akademie GmbHData:konferencja 2-5.09.2018Status:Published
- Characterization of murine MC38 colon carcinoma microenvironment after application of lentivectors silencing IL-10 or IL-10R expressionAuthors:Anger N, Napierała M, Szczygieł A, Mierzejewska J, Węgierek K, Pajtasz-Piasecka E, Rossowska JConference:2nd Wroclaw Scientific Meetings (rok: 2018, ), Wydawca: Wydawnictwo Naukowe TYGIELData:konferencja 01.03.2018Status:Published
- Optymalizacja hodowli mysich mieloidalnych komórek supresorowychAuthors:Anger N, Rossowska JConference:I Wrocławskie Spotkania Naukowe (rok: 2017, ), Wydawca: Wydawnictwo Naukowe TYGIELData:konferencja 03.03.2017Status:Published
- Characteristic of in vitro-induced myeloid-derived suppressor cells with silenced expression of IL-10 or IL-10RAuthors:Anger N, Szczygieł A, Mierzejewska J, Pajtasz-Piasecka E, Rossowska JConference:XVI Zjazd Polskiego Towarzystwa Immunologii Doświadczalnej i Klinicznej (rok: 2017, ), Wydawca: TERMEDIA Publishing House Ltd.Data:konferencja 08-10.06.2017Status:Published