Projects funded by the NCN
The effect of typical and atypical neuroleptics on the expression of cytochrome P450 isoenzymes 1A2 (CYP1A2) and 3A4 (CYP3A4) in human hepatocytes.
2014/15/N/NZ7/02955
Keywords:
levomepromazine clozapine cytochrome P450 induction hepatocytes
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Instytut Farmakologii PAN
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 8 - announced on 2014-09-15
Amount awarded: 99 960 PLN
Project start date (Y-m-d): 2015-09-02
Project end date (Y-m-d): 2018-07-01
Project duration:: 34 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (1)
- Articles in post-conference publications (1)
- Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4Authors:Danek P.J., Basińska-Ziobroń A., Wójcikowski J., Daniel W.A.Academic press:Pharmacological Reports (rok: 2020, tom: -, strony: -), Wydawca: Springer NatureStatus:PublishedDOI:10.1007/s43440-020-00157-4 - link to the publication
- Clozapine and levomepromazine induce the cytochrome P450 isoenzyme CYP3A4, but not CYP1A1/2, in human hepatocytesAuthors:Danek P., Basińska-Ziobroń A., Daniel W.A., Wójcikowski J.Conference:30th ECNP Congress, Paris, France (rok: 2017, ), Wydawca: ElsevierData:konferencja 2-5 wrzesieńStatus:Published