Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The influence of bone marrow microenvironment on the regulation of BRCA1 mRNA translation in leukemia cells; role in the cells invasiveness and therapy resistance

2014/15/D/NZ3/05187

Keywords:

leukemia hypoxia translation eIF2alpha BRCA1 bone marrow microenvironment synthetic lethality mRNA binding protein TIAR HuR

Descriptors:

  • NZ3_7: Signal transduction
  • NZ3_1: Cell biology
  • NZ3_3: Apoptosis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Podszywałow-Bartnicka 

Number of co-investigators in the project: 4

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 950 000 PLN

Project start date (Y-m-d): 2015-07-23

Project end date (Y-m-d): 2019-07-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. NanoDrop 2000 ThermoScientific.
  2. komora hipoksyjna Whitley H45 Hypoxystation (300 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (13)
  • Book publications / chapters in book publications (1)
  1. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells
    Authors:
    Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Hoser G, Maifrede S, Martinez E, Di Marcantonio D, Bolton-Gillespie E, Cramer-Morales K, Lee J, Li M, Slupianek A, Gritsyuk D, Cerny-Reiterer S, Seferynska I, Stoklosa T, Bullinger L, Zhao H, Gorbunova V, Piwocka K, Valent P, Civin CI, Muschen M, Dick JE, Wang JC, Bhatia S, Bhatia R, Eppert K, Minden MD, Sykes SM, Skorski T.
    Academic press:
    J Clin Invest. (rok: 2017, tom: 127(6), strony: 2392-2406), Wydawca: The American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/JCI90825 - link to the publication
  2. PARP1 inhibitor eliminated imatinib-refractory chronic myeloid leukemia cells in bone marrow microenvironment conditions
    Authors:
    Podszywalow-Bartnicka P, Maifrede S, Lea BV, Nieborowska-Skorska M, Piwocka K, Skorski T
    Academic press:
    Leukemia and Lymphoma (rok: 2018, tom: 60 (1), strony: 262-264), Wydawca: TAYLOR & FRANCIS LTD
    Status:
    Published
    DOI:
    10.1080/10428194.2018.1471602. - link to the publication
  3. BRCA1 deficiency and synthetic lethality in leukemias; not only gene mutation matters
    Authors:
    Piwocka K, Podszywałow-Bartnicka P, Skorski T
    Academic press:
    Postepy Biochemii (rok: 2018, tom: 64(2), strony: 141-147), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_124 - link to the publication
  4. TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
    Authors:
    Magdalena Wolczyk, Remigiusz Serwa, Agata Kominek, Agata Klejman, Jacek Milek, Marta Jakubik, Laura Turos-Korgul, Agata Charzynska, Michal Dabrowski, Magdalena Dziembowska, Tomasz Skorski, Katarzyna Piwocka, Paulina Podszywalow-Bartnicka
    Academic press:
    iSCIENCE (rok: 2022, ), Wydawca: Cell Press
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Characteristics of Live Parameters of the HS-5 Human Bone Marrow Stromal Cell Line Cocultured with the Leukemia Cells in Hypoxia, for the Studies of Leukemia–Stroma Cross-Talk
    Authors:
    Podszywalow-Bartnicka P, Kominek A, Kolba M, Wolczyk M, Piwocka K
    Academic press:
    Cytometry, Part A (rok: 2018, tom: 93(9), strony: 929-940), Wydawca: International Society for Advencement of Cytometry
    Status:
    Published
    DOI:
    10.1002/cyto.a.23580 - link to the publication
  6. Stress granules assembly affects detection of mRNA in living cells by the NanoFlares; an important aspect of the technology.
    Authors:
    Wolczyk M, Podszywalow-Bartnicka P, Bugajski L, Piwocka K.
    Academic press:
    Biochim Biophys Acta (rok: 2017, tom: Volume 1861 (5), strony: 1024–1035), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagen.2017.02.010 - link to the publication
  7. Increased phosphorylation of eIF2α in chronic myeloid leukemia cells stimulates secretion of matrix modifying enzymes
    Authors:
    Podszywalow-Bartnicka P, Cmoch A, Wolczyk M, Bugajski L, Tkaczyk M, Dadlez M, Nieborowska-Skorska M, Koromilas AE, Skorski T, Piwocka K
    Academic press:
    Oncotarget (rok: 2016, tom: 7 (48), strony: 79706-79721), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.12941 - link to the publication
  8. Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors
    Authors:
    Maifrede S, Nieborowska-Skorska M, Sullivan K, Dasgupta Y, Podszywalow-Bartnicka P, Le BV, Solecka M, Lian Z, Belyaeva EA, Nersesyan A, Machnicki MM, Chatain N, Rydzanicz M, Zhao H, Jelinek J, Piwocka K, Stoklosa T, Ploski R, Fischer T, Sykes SM, Koschmieder S, Bullinger L, Valent P, Wasik M, Huang J, Skorski T
    Academic press:
    BLOOD (rok: 2018, tom: 132 (1), strony: 67-77), Wydawca: The American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2018-02-834895. - link to the publication
  1. Formation of RNA binding protein complexes regulates BRCA1 mRNA translation in chronic myeloid leukemia cells
    Authors:
    Wolczyk M, Podszywalow-Bartnicka P, Piwocka P
    Conference:
    EMBO Conference "Eucaryotic RNA turnover" (rok: 2017, ), Wydawca: EMBO Press
    Data:
    konferencja 10-13.07.2017
    Status:
    Published
  2. Stress response signaling in leukemia cells modifies profile of released proteases to support invasion.
    Authors:
    Paulina Podszywalow-Bartnicka, Anna Cmoch, Magdalena Wolczyk, Marta Tkaczyk, Michal Dadlez, Tomasz Skorski, Katarzyna Piwocka
    Conference:
    EMBO EMBL symposium: Tumour Microenvironment and Signalling (rok: 2016, ), Wydawca: EMBO
    Data:
    konferencja 3-6.04.2016
    Status:
    Published
  3. BCR-ABL dependent formation of RNA binding protein complexes as a novel mechanism of decreased translation and BRCA1 deficiency in leukemia cells
    Authors:
    Wolczyk M, Podszywalow-Bartnicka P, Piwocka K
    Conference:
    2nd International Sympozjum on "Stress-Associated RNA Granules in Human Disease and Viral Infection" (rok: 2017, ), Wydawca: Universitatsmedizin Mannheim
    Data:
    konferencja 10-12.09.2017
    Status:
    Published
  4. RBP complexes regulate BRCA1 mRNA translation in mouse and human CML cell lines
    Authors:
    Wolczyk M, Podszywalow-Bartnicka P, Turos L, Piwocka K
    Conference:
    RNP network dynamics in development and disease (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 29.09-02.10.2019
    Status:
    Published
  5. Regulation of BRCA1 translation by RBPs - differences between mouse and human CML cell lines
    Authors:
    Wolczyk M, Podszywalow-Bartnicka P, Piwocka K
    Conference:
    EMBO Workshop "The DNA-damage response in cell physiology and disease" (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 07-11.10.2019
    Status:
    Published
  6. Response of FXR1P and FXR2P proteins to hypoxia in leukemia cells
    Authors:
    Wolczyk M, Piwocka K, Podszywalow-Bartnicka P
    Conference:
    EMBO/EMBL The complex life of mRNA (rok: 2018, ), Wydawca: EMBO/EMBL
    Data:
    konferencja 3-6.10.2018
    Status:
    Published
  7. Not Only Gene Mutations Matter: Incorporation of Flow Cytometry to Identify BRCA1-Deficient Leukemias Susceptible to Synthetic Lethality by PARP1-Inhibitors
    Authors:
    K. Piwocka, P. Podszywalow-Bartnicka, M. Nieborowska-Skorska, M. Wolczyk, L. Bugajski, T. Skorski
    Conference:
    33rd Congress of ISAC CYTO 2018" (rok: 2018, ), Wydawca: International Society for Advencement of Cytometry
    Data:
    konferencja 28.04-02.05.2018
    Status:
    Published
  8. Stress-induced signaling in chronic myeloid leukemia promotes cells invasiveness
    Authors:
    Podszywalow-Bartnicka P, Cmoch A, Wesolowska A, Bugajski L, Tkaczyk M, Dadlez M, Skorski T, Piwocka K
    Conference:
    8th International Conference On Tumour Microenvironment: Progression, Therapy & Prevention (rok: 2018, ), Wydawca: The International Cancer Microenvironment Society
    Data:
    konferencja 10-14.06.2018
    Status:
    Published
  9. Influence of hypoxia on the composition of RNA binding proteins complexes in leukemia cells
    Authors:
    Podszywalow-Bartnicka P, Wolczyk M, Turos LA, Jakubik M, Dabrowska Z, Piwocka K
    Conference:
    EMBO Workshop RNP network dynamics in development and disease (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 29.09-02.10.2019
    Status:
    Published
  10. Hypoxia-induced response of RNA binding proteins in leukemia cells
    Authors:
    Wolczyk M, Turos LA, Jakubik M, Dabrowska Z, Piwocka K, Podszywalow-Bartnicka P
    Conference:
    24th Annual Meeting of the RNA Society (rok: 2019, ), Wydawca: RNA Society
    Data:
    konferencja 11-16.06.2019
    Status:
    Published
  11. Stress-induced signaling in chronic myeloid leukemia promotes cells invasiveness
    Authors:
    Podszywalow-Bartnicka P, Cmoch A, Wesolowska A, Bugajski L, Tkaczyk M, Dadlez M, Skorski T, Piwocka K
    Conference:
    International Society of Cancer Microenvironment Conference Tumor microenvironment: progression, therapy & prevention (rok: 2018, ), Wydawca: International Society of Cancer Microenvironment
    Data:
    konferencja 10-14.06.2018
    Status:
    Published
  12. Synthetic lethality in bone marrow niche
    Authors:
    Podszywalow-Bartnicka P, Maifrede S, Kozlowska E, Le BV, Wolczyk M, Nieborowska-Skorska M, Skorski T, Piwocka K
    Conference:
    3rd Scientific workshop "The haematological tumour microenvironment and its therapeutic targeting" (rok: 2019, ), Wydawca: European School of Haematology
    Data:
    konferencja 24-26.02.2019
    Status:
    Published
  13. Usage of PARP1 inhibitors to target leukemia cells in bone marrow mimicking conditions
    Authors:
    Podszywalow-Bartnicka P, Maifrede S, Kozlowska E, Le BV, Wolczyk M, Nieborowska-Skorska M, Skorski T, Piwocka K
    Conference:
    EMBO Workshop "The DNA-damage response in cell physiology and disease" (rok: 2019, ), Wydawca: EMBO
    Data:
    konferencja 07-11.10.2019
    Status:
    Published
  1. Going insight the leukemia microenvironment and cell-cell intractions using flow cytometry
    Authors:
    Piwocka K, Podszywalow-Bartnicka P, Swatler J, Kolba M, Kominek A, Kozlowska E
    Book:
    Multidimensional Flow Cytometry Techniques for Novel Highly Informative Assays (rok: 2018, tom: --, strony: --), Wydawca: InTech
    Status:
    Published

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