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Effect of peritoneal mesothelium senescence on the functionality of intercellular junctions and the inducibility of epithelial-mesenchymal transition of malignant cells, in the context of the identification of a new mechanism of transmesothelial invasiveness of ovarian cancer

2014/15/B/NZ3/00421

Keywords

Descriptors

  • NZ3_4: Starzenie
  • NZ3_1: Biologia komórki
  • NZ3_14: Inne zagadnienia pokrewne

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Krzysztof Stefan Książek

Number of co-investigators in the project: 6

Call

OPUS 8 – announced on 2014-09-15

Amount awarded
677 320 PLN
Project start date
2015-07-24
Project end date
2018-07-23
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Autoklaw do klatek dla zwierząt. Cost: 70 000 PLN
  2. Loża z laminarnym przepływem powietrza do badań na zwierzętach. Cost: 40 000 PLN
  3. Mikroskop fluorescencyjny odwrócony.
  4. Sterylizator na suche gorące powietrze.
  5. System oczyszczania wody.

Information in the final report

Publication in academic press/journals (12)

  1. The epithelial-mesenchymal transition initiated by malignant ascites underlies the transmesothelial invasion of ovarian cancer cells

    Authors:
    Pakuła M., Mikuła-Pietrasik J., Witucka A., Kostka-Jeziorny K., Uruski P., Moszyński R., Naumowicz E., Sajdak S., Tykarski A., Książek K.
    Academic press:
    Int J Molec Sci (year: 2019, volume: 20, 137, pages: 46032), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20010137 – link to the publication

  2. A unique pattern of mesothelial-mesenchymal transition induced in the normal peritoneal mesothelium by high-grade serous ovarian cancer

    Authors:
    Pakuła M, Uruski P, Niklas A., Woźniak A, Szpurek D., Tykarski A., Mikuła-Pietrasik J., Książek K
    Academic press:
    Cancers (year: 2019, volume: 11, pages: 662), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11050662 – link to the publication

  3. Malignant ascites determine the transmesothelial invasion of ovarian cancer cells

    Authors:
    Mikuła-Pietrasik J, Uruski P, Szubert S, Szpurek D, Sajdak S., Tykarski A, Książek K
    Academic press:
    International Journal of Biochemistry and Cell Biology (year: 2017, volume: 92, pages: 46186), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2017.09.002 – link to the publication

  4. Mitochondria-related oxidative stress contributes to ovarian cancer-promoting activity of mesothelial cells subjected to malignant ascites.

    Authors:
    Pakuła M, Mikuła-Pietrasik J, Stryczyński Ł, Uruski P, Szubert S, Moszyński R, Szpurek D, Sajdak S, Tykarski A, Książek K.
    Academic press:
    International Journal of Biochemistry and Cell Biology (year: 2018, volume: 98, pages: 82-88), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2018.03.011 – link to the publication

  5. The peritoneal soil for a cancerous seed: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases

    Authors:
    Mikuła-Pietrasik J, Uruski P, Tykarski A, Książek K
    Academic press:
    Cellular and Molecular Life Sciences (year: 2018, volume: 75, pages: 509-525), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-017-2663-1 – link to the publication

  6. Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.

    Authors:
    Mikuła-Pietrasik J, Uruski P, Pakuła M, Maksin K, Szubert S, Woźniak A, Naumowicz E, Szpurek D, Tykarski A, Książek K
    Academic press:
    Free Radical Biology & Medicine (year: 2017, volume: 110, pages: 270-279), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2017.06.015 – link to the publication

  7. Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells

    Authors:
    Pakuła M, Witucka A, Uruski P, Radziemski A, Moszyński R, Szpurek D, Maksin K, Woźniak A, Sajdak S, Tykarski A, Mikuła-Pietrasik J, Książek K
    Academic press:
    Scientific Reports (year: 2019, volume: 20, pages: 7587), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-44123-4 – link to the publication

  8. Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases

    Authors:
    Mikuła-Pietrasik J, Uruski P, Sosińska P, Maksin K, Piotrowska-Kempisty H, Kucińska M, Murias M, Szubert S, Woźniak A, Szpurek D, Sajdak S, Piwocka K, Tykarski A, Książek K
    Academic press:
    Cell Death Dis (year: 2016, volume: 7, pages: e2565), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/cddis.2016.417 – link to the publication

  9. Biochemical composition of malignant ascites determines high aggressiveness of undifferentiated ovarian tumors

    Authors:
    Mikuła-Pietrasik J., Uruski P., Szubert S., Moszyński R., Szpurek D., Sajdak S., Tykarski A., Książek K
    Academic press:
    Medical Oncology (year: 2016, volume: 33, pages: 94), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12032-016-0810-4 – link to the publication

  10. Procancerogenic activity of senescent cells: A case of the peritoneal mesothelium

    Authors:
    Mikuła-Pietrasik J, Stryczyński Ł, Uruski P, Tykarski A, Książek K
    Academic press:
    Ageing Research Reviews (year: 2018, volume: 43, pages: 46031), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2018.01.002 – link to the publication

  11. Ovarian cancer-derived ascitic fluids induce a senescence-dependent pro-cancerogenic phenotype in normal peritoneal mesothelial cells

    Authors:
    Mikuła-Pietrasik J., Uruski P., Matuszkiewicz K., Szubert S., Moszyński R., Szpurek D., Sajdak S., Tykarski A., Książek K
    Academic press:
    Cellular Oncology (year: 2016, volume: 39, pages: 473-481), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s13402-016-0289-1 – link to the publication

  12. The proangiogenic capabilities of malignant ascites generated by aggressive ovarian tumors

    Authors:
    Mikuła-Pietrasik J, Uruski P, Szubert S., Maksin K., Moszyński R., Szpurek D., Woźniak A, Sajdak S, Tykarski A, Książek K
    Academic press:
    BioMed Research International (year: 2017, volume: ID 2592496, pages: 46031), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/2592496 – link to the publication

Articles in post-conference publications (9)

  1. Malignant ascites from aggressive type II ovarian tumors promote angiogenesis more efficiently than those from less aggressive type I cancers

    Authors:
    Mikuła-Pietrasik J., Szubert S., Maksin K. Moszyński R., Wozniak A., Szpurek D., Sajdak S., Książek K
    Conference:
    9. International Charite-Mayo Conference (year: 2017, pages: 10), Publisher: Charite
    Date:
    conference 3-6 maja
    Status:
    Published

  2. Senescence of peritoneal mesothelial cells from a mechanistic and clinical perspective

    Authors:
    Mikuła-Pietrasik J., Książek K
    Conference:
    10th European Congress of Biogerontology and 6th Meeting at the Nencki Institute (year: 2016, pages: L21), Publisher: Instytut Nenckiego PAN
    Date:
    conference Sept 23-24
    Status:
    Published

  3. Cancer cell-derived hepatocyte growth factor triggers senescence of peritoneal mesothelium contributing to increased transmesothelial invasion of ovarian cancer cells.

    Authors:
    Mikuła-Pietrasik J., Pakuła M., Maksin K., Szubert S., Wozniak A., Szpurek D., Książek K
    Conference:
    27th Congress of the Polish Physiological Society (year: 2017, pages: 115), Publisher: Wydawnictwo Uniwersytetu Jagiellońskiego
    Date:
    conference 21-27 września
    Status:
    Published

  4. Ovarian Cancer-derived hepatocyte growth factor (HGF), insulin-like growth factor and transforming growth factor beta1 induce epithelial-mesenchymal transition in peritoneal mesothelium in Smad2/3-dependent mechanism, improving the progression of the cancer cells

    Authors:
    Mikuła-Pietrasik J., Pakuła M., Szubert S., Szpurek D., Książek K
    Conference:
    27th Congress of the Polish Physiological Society (year: 2017, pages: 115), Publisher: Wydawnictwo Uniwersytetu Jagiellońskiego
    Date:
    conference 21-27 września
    Status:
    Published

  5. Ovarian cancer cells induce senescence in the peritoneal mesothelium which facilitates their transmesothelial invasion

    Authors:
    Mikuła-Pietrasik J., Maksin K., Szubert S., Moszyński R., Wozniak A., Szpurek D., Sajdak S., Książek K
    Conference:
    10th European Congress of Biogerontology and 6th Meeting at the Nencki Institute (year: 2016, pages: P44), Publisher: Instytut Nenckiego PAN
    Date:
    conference Sept 23-24
    Status:
    Published

  6. A new mechanism of transmesothelial invasion of ovarian cancer cells involving senescence of normal peritoneal mesothelium

    Authors:
    Mikuła-Pietrasik J., Książek K.
    Conference:
    2nd Congress Bio2016 (year: 2016, pages: 34), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 13-16 Sept
    Status:
    Published

  7. Intraperitoneal invasiveness of ovarian cancer cells is facilitated by their ability to promote senescence and EMT in normal peritoneal mesothelium

    Authors:
    Mikuła-Pietrasik J., Maksin K., Szubert S., Wozniak A., Szpurek D., Książek K.
    Conference:
    International Charite-Mayo Conference (year: 2017, pages: 6), Publisher: Charite
    Date:
    conference 3-6 maja
    Status:
    Published

  8. Transmesothelial invasiveness of ovarian cancer cells is associated with their ability to induce premature senescence and EMT in normal peritoneal mesothelium

    Authors:
    Mikuła-Pietrasik J., Maksin K., Szubert S., Moszyński R., Wozniak A., Szpurek D., Sajdak S., Książek K
    Conference:
    2nd Congress Bio2016 (year: 2016, pages: 38), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 13-16 Sept
    Status:
    Published

  9. Transmesothelial invasion of ovarian cancer cells is stimulated by malignant ascites in a mechanism involving oxidative stress-dependent deterioration of intercellular junctions in peritoneal mesothelium

    Authors:
    Mikuła-Pietrasik J., Szubert S., Moszyński R., Szpurek D., Sajdak S., Książek K.
    Conference:
    9. International Charite-Mayo Conference (year: 2017, pages: 6), Publisher: Charite
    Date:
    conference 3-6 maja
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski