Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Quantitative proteomics in yeast model of hyperhomocysteinemia

2014/15/B/NZ2/01079

Keywords:

homocysteine thiolactone hyperhomocysteinemia proteome yeasts

Descriptors:

  • NZ2_3: Proteomics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Perła-Kaján 

Number of co-investigators in the project: 4

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 781 690 PLN

Project start date (Y-m-d): 2015-07-17

Project end date (Y-m-d): 2020-04-16

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Urządzenie do homogenizacji (49 590 PLN)
  2. Wytrząsarka platformowa z termostatowanym inkubatorem (27 760 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (5)
  1. The Cbs Locus Affects the Expression of Senescence Markers and mtDNA Copy Number, but not Telomere Dynamics in Mice
    Authors:
    Utyro O, Perła-Kaján J, Jakubowski H.
    Academic press:
    Intrnational Journal of Molecular Sciences (rok: 2020, tom: 21(7), strony: 2520), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072520 - link to the publication
  2. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities
    Authors:
    Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.
    Academic press:
    FASEB J (rok: 2016, tom: 30, strony: 3810-3821), Wydawca: Federation of American Societies for Experimental Biology
    Status:
    Published
    DOI:
    10.1096/fj.201600539 - link to the publication
  3. Proteome-wide analysis of protein lysine N-homocysteinylation in Saccharomyces cerevisiae
    Authors:
    Perła-Kaján J, Malinowska A, Zimny J, Cysewski D, Suszyńska-Zajczyk J, Jakubowski H.
    Academic press:
    Journal of Proteome Research (rok: 2021, tom: 20, strony: 2458-2476), Wydawca: American Chemical Society (United States)
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.0c00937 - link to the publication
  4. Telomere length and mtDNA copy number in human cystathionine β-synthase deficiency
    Authors:
    Utyro O, Perła-Kaján J, Kubalska J, Graban A, Jakubowski H.
    Academic press:
    Free Radic Biol Med (rok: 2020, tom: 160, strony: 219-226), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.07.036 - link to the publication
  5. Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia.
    Authors:
    Perła-Kaján J, Jakubowski H.
    Academic press:
    Intrnational Journal of Molecular Sciences (rok: 2019, tom: 20(13), strony: pii: E3140), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133140 - link to the publication
  1. N-homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities
    Authors:
    Joanna Perła - Kajan, Marta Rusek, Agata Malinowska, Ewa Sitkiewicz, Olga Utyro , and Hieronim Jakubowski
    Conference:
    11th International Conference on Homocysteine and One-Carbon Metabolism, Aarhus, Dania (rok: 2017, ), Wydawca: Aarhus University
    Data:
    konferencja 14-18.05
    Status:
    Published
    DOI:
    link to the publication
  2. Homocysteina zmienia ekspresję mRNA białek rybosomalnych, kinaz SNF1 i YPK3 oraz fosforylację białka rybosomalnego S6 w komórkach drożdży Saccharomyces cerevisiae
    Authors:
    Drozdowska Z, Utyro O, Perła-Kaján J, Jakubowski H
    Conference:
    Nowe Wyzwania Dla Polskiej Nauki - IV Edycja (rok: 2018, ), Wydawca: Creativetime
    Data:
    konferencja 1,12
    Status:
    Published
    DOI:
    link to the publication
  3. Proteomic analysis reveals deregulated protein folding, oxidative stress, and apoptosis signaling pathways in the yeast Saccharomyces cerevisiae model of hyperhomocysteinemia
    Authors:
    Joanna Perła-Kaján, Jarosław Zimny, Agata Malinowska, Dominik Cysewski, Hieronim Jakubowski
    Conference:
    3rd Congress of Polish Biosciences BIO2018 and the 51st Meeting of the Polish Biochemical Society (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 18-21.09
    Status:
    Published
    DOI:
    link to the publication
  4. The role of bleomycin hydrolase in YEAST mitochondria functionality
    Authors:
    Zimny J, Grobys D, Perła-Kaján J, Kmita H
    Conference:
    3rd Congress of Polish Biosciences BIO2018 and the 51st Meeting of the Polish Biochemical Society (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 18-21.09
    Status:
    Published
    DOI:
    link to the publication
  5. N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities
    Authors:
    Perła-Kajan J, Utyro O, Rusek M, Malinowska A, Sitkiewicz E, Jakubowski H.
    Conference:
    2nd Congress BIO 2016 (rok: 2016, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 13-16.09
    Status:
    Published

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