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The functional meaning of the protein kinase C beta (PKC beta) translocation due to cerebral ischemia. Solving the puzzle of endogenous neuroprotection.

2014/15/D/NZ3/02784

Keywords

Descriptors

  • NZ3_7: Przekaźnictwo sygnału
  • NZ3_3: Apoptoza
  • NZ3_6: Neurobiologia komórkowa

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Małgorzata Beręsewicz

Number of co-investigators in the project: 4

Call

SONATA 8 – announced on 2014-09-15

Amount awarded
655 750 PLN
Project start date
2015-09-22
Project end date
2019-09-21
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. -.
  2. Płuczka do ELISA. Cost: 33 000 PLN
  3. System do wylewania żeli gradientowych. Cost: 17 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase

    Authors:
    Beręsewicz-Haller M, Krupska O, Bochomulski P, Dudzik D, Chęcińska A, Hilgier W, Barbas C, Zablocki K, Zablocka B.
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 8504-8518), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168504 – link to the publication

  2. Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus.

    Authors:
    Krupska O, Sarnowska A, Fedorczyk B, Gewartowska M, Misicka A, Zablocka B, Beresewicz M
    Academic press:
    Neurochemical Research (year: 2017, volume: 42, pages: 2392-2403), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-017-2263-3. – link to the publication

Articles in post-conference publications (5)

  1. A link between glutamine metabolism and selective neuronal vulnerability in the hippocampus

    Authors:
    Bochomulski P., Krupska O., Klimczak P., Hilgier W., Zabłocka B., Beręsewicz M.
    Conference:
    14th International Congress of Polish Neuroscience Society (PTBUN) (year: 2019, pages: LXII-LXIII), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 28-30.08.2019
    Status:
    Published

  2. PKC beta II translocation to mitochondria as a component of endogenous neuroprotection

    Authors:
    Krupska, O., Sarnowska A., Zablocka B., Beresewicz M.
    Conference:
    42nd Congress of the Federation of European Biochemical Societies (FEBS) on From Molecules to Cells and Back (year: 2017, pages: 243-244), Publisher: FEBS JOURNAL
    Date:
    conference 10-14.09.2017
    Status:
    Published

  3. Ischemia/reperfusion-induced translocation of protein kinase C beta II to mitochondria results in phosphorylation of respiratory complex I subunit

    Authors:
    Krupska O, Sitkiewicz E,Charzewski Ł, Krzyśko K, Zabłocka B, Beresewicz M
    Conference:
    Neurochemical Conference 2017: Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (year: 2017, pages: 271), Publisher: Folia Neuropathologica
    Date:
    conference 19-20.10.2017
    Status:
    Published

  4. Ischemia/reperfusion-induced translocation of protein kinase C βII to mitochondria results in endogenous neuroprotection. A potential neuroprotective strategy.

    Authors:
    Klimczak P., Krupska O., Sarnowska A., Sitkiewicz E., Charzewski L., Krzysko K., Zablocka B., Beresewicz M.
    Conference:
    The 14th International Symposium Molecular basis of pathology and therapy in neurological disorders (year: 2018, pages: 250-251), Publisher: Folia Neuropathologica
    Date:
    conference 25-26.10.2018
    Status:
    Published

  5. Is mitochondrial glutaminase involved in endogenous neuroprotection induced by protein kinase C βII?

    Authors:
    Bochomulski P., Krupska O., Klimczak P., Sarnowska A., Sitkiewicz E., Zablocka B., Beresewicz M.
    Conference:
    14th International Symposium Molecular basis of pathology and therapy in neurological disorders (year: 2018, pages: page 247-248), Publisher: Folia Neuropathologica
    Date:
    conference 25-26.10.2018
    Status:
    Published

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