Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The functional meaning of the protein kinase C beta (PKC beta) translocation due to cerebral ischemia. Solving the puzzle of endogenous neuroprotection.

2014/15/D/NZ3/02784

Keywords:

brain ischemia proten kinase C mitochondria

Descriptors:

  • NZ3_7: Signal transduction
  • NZ3_3: Apoptosis
  • NZ3_6: Cell neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Beręsewicz 

Number of co-investigators in the project: 4

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 655 750 PLN

Project start date (Y-m-d): 2015-09-22

Project end date (Y-m-d): 2019-09-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. -.
  2. System do wylewania żeli gradientowych (17 000 PLN)
  3. Płuczka do ELISA (33 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus.
    Authors:
    Krupska O, Sarnowska A, Fedorczyk B, Gewartowska M, Misicka A, Zablocka B, Beresewicz M
    Academic press:
    Neurochemical Research (rok: 2017, tom: 42, strony: 2392-2403), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-017-2263-3. - link to the publication
  2. Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKCβII and Phosphate-Activated Glutaminase
    Authors:
    Beręsewicz-Haller M, Krupska O, Bochomulski P, Dudzik D, Chęcińska A, Hilgier W, Barbas C, Zablocki K, Zablocka B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 8504-8518), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168504 - link to the publication
  1. Ischemia/reperfusion-induced translocation of protein kinase C βII to mitochondria results in endogenous neuroprotection. A potential neuroprotective strategy.
    Authors:
    Klimczak P., Krupska O., Sarnowska A., Sitkiewicz E., Charzewski L., Krzysko K., Zablocka B., Beresewicz M.
    Conference:
    The 14th International Symposium "Molecular basis of pathology and therapy in neurological disorders" (rok: 2018, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 25-26.10.2018
    Status:
    Published
  2. A link between glutamine metabolism and selective neuronal vulnerability in the hippocampus
    Authors:
    Bochomulski P., Krupska O., Klimczak P., Hilgier W., Zabłocka B., Beręsewicz M.
    Conference:
    14th International Congress of Polish Neuroscience Society (PTBUN) (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 28-30.08.2019
    Status:
    Published
  3. Ischemia/reperfusion-induced translocation of protein kinase C beta II to mitochondria results in phosphorylation of respiratory complex I subunit
    Authors:
    Krupska O, Sitkiewicz E,Charzewski Ł, Krzyśko K, Zabłocka B, Beresewicz M
    Conference:
    Neurochemical Conference 2017: Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 19-20.10.2017
    Status:
    Published
  4. PKC beta II translocation to mitochondria as a component of endogenous neuroprotection
    Authors:
    Krupska, O., Sarnowska A., Zablocka B., Beresewicz M.
    Conference:
    42nd Congress of the Federation of European Biochemical Societies (FEBS) on From Molecules to Cells and Back (rok: 2017, ), Wydawca: FEBS JOURNAL
    Data:
    konferencja 10-14.09.2017
    Status:
    Published
  5. Is mitochondrial glutaminase involved in endogenous neuroprotection induced by protein kinase C βII?
    Authors:
    Bochomulski P., Krupska O., Klimczak P., Sarnowska A., Sitkiewicz E., Zablocka B., Beresewicz M.
    Conference:
    14th International Symposium "Molecular basis of pathology and therapy in neurological disorders" (rok: 2018, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 25-26.10.2018
    Status:
    Published

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