Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of therapeutic efficacy of selected azaphenothiazines and studies on the mechanism of the immunosuppressive activity

2014/15/B/NZ7/00867

Keywords:

azaphenotiazines immune suppression skin transplant psoriasis contact sensitivity colitis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Michał Zimecki 

Number of co-investigators in the project: 17

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 625 500 PLN

Project start date (Y-m-d): 2015-09-01

Project end date (Y-m-d): 2017-11-30

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Waga analityczna (26 000 PLN)
  2. Blok grzewczy (7 000 PLN)
  3. Homogenizator ultradźwiekowy (31 443 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Selected azaphenothiazines inhibit delayed type hypersensitivity and carrageenan reaction in mice
    Authors:
    Jolanta Artym, Iwona E. Kochanowska, Maja Kocięba, Ewa Zaczyńska, Michał Zimecki, Małgorzata Jeleń, Beata Morak-Młodawska, Krystian Pluta
    Academic press:
    International Immunopharmacology (rok: 2016, tom: 40, strony: 265-268), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2016.09.005 - link to the publication
  2. Prolongation of skin graft survival in mice by an azaphenothiazine derivative.
    Authors:
    Artym J, Kocięba M, Zaczyńska E, Kochanowska I, Zimecki M, Kałas W, Strządała L, Zioło E, Jeleń M, Morak-Młodawska B, Pluta K
    Academic press:
    Immunology Letters (rok: 2019, tom: 208, strony: 45298), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.imlet.2019.02.006 - link to the publication
  3. Topically applied azaphenothiazines inhibit experimental psoriasis in mice
    Authors:
    Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Michał Zimecki, Wojciech Kałas, Anna Fiedorowicz, Leon Strządała, Małgorzata Jeleń, Beata Morak-Młodawska, Krystian Pluta, Katarzyna Kaleta-Kuratewicz, Jan P. Madej, Piotr Kuropka, Jan Kuryszko
    Academic press:
    International Immunopharmacology (rok: 2018, tom: 59, strony: 276-286), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2018.03.028 - link to the publication
  4. An Anti-Inflammatory Azaphenothiazine Inhibits Interferon beta Expression and CXCL10 Production in KERTr Cells
    Authors:
    Leon Strzadala, Anna Fiedorowicz, Edyta Wysokinska, Ewa Ziolo, Małgorzata Grudzień, Malgorzata Jelen, Krystian Pluta, Beata Morak-Mlodawska, Michal Zimecki and Wojciech Kalas
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2443), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23102443 - link to the publication
  5. Topically applied azaphenothiazines inhibit contact sensitivity to oxazolone in mice
    Authors:
    Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Michał Zimecki, Małgorzata Jeleń, Beata Morak-Młodawska, Krystian Pluta, Katarzyna Kaleta-Kuratewicz, Jan P. Madej, Piotr Kuropka and Jan Kuryszko
    Academic press:
    HISTOLOGY AND HISTOPATHOLOGY (rok: 2018, tom: 33, strony: 223-236), Wydawca: F HERNANDEZ, PLAZA FUENSANTA 2-7 C, 30008 MURCIA, SPAIN
    Status:
    Published
    DOI:
    10.14670/HH-11-921 - link to the publication

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