Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Carbamylation as a modulator of immune response

2014/14/E/NZ6/00162

Keywords:

carbamylation IgG LL37 autoimmune diseases post-translational modifications

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ1_2: Biochemistry
  • NZ3_1: Cell biology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Mydel 

Number of co-investigators in the project: 4

Call: SONATA BIS 4 - announced on 2014-06-16

Amount awarded: 1 472 835 PLN

Project start date (Y-m-d): 2015-07-01

Project end date (Y-m-d): 2020-06-30

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Gel Doc EZ Imager.
  2. Inkubator CO2 (26 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Carbamylated LL-37 as a modulator of the immune response
    Authors:
    Koro C, Hellvard A, Delaleu N, Binder V, Scanevius C,, Bergum B, Glowczyk I, Roberts H, Chapple ILC, Grant MM, Rapala-Kozik M, Potempa J, Mydel P
    Academic press:
    Innate Immunity (rok: 2016, tom: Vol. 22(3), strony: 218–229), Wydawca: Sage
    Status:
    Published
    DOI:
    10.1177/1753425916631404 - link to the publication
  2. Effects by periodontitis on pristane-induced arthritis in rats
    Authors:
    Eriksson K, Lönnblom E, Tour G, Kats A, Mydel P, Georgsson P, Hultgren C, Kharlamova; N, Norin U, Jöonsson J, Lundmark A, Hellvard A, Lundberg K, Jansson L, Holmdahl R, Yucel-Lindberg T
    Academic press:
    Journal of Translational Medicine (rok: 2016, tom: 0,799305555555556, strony: NA), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12967-016-1067-6 - link to the publication
  3. Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis
    Authors:
    A. Hellvard, L. Zeitlmann, U.Heiser, A.Kehlen, A.Nisteroi, H.U.Demuth, J.Koziel, N. Delelau, J.Potempa, P.Mydel
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: NA), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep31441 - link to the publication
  4. Antibodies against carbamylated proteins are present in primary Sjögren's syndrome and are associated with disease severity.
    Authors:
    Bergum B, Koro C, Delaleu N, Solheim M, Hellvard A, Binder V, Jonsson R, Valim V, Hammenfors DS, Jonsson MV, Mydel P.
    Academic press:
    Annals of Rheumatic Diseases (rok: 2015, tom: 75(8), strony: 1494–1500), Wydawca: BMJ Journals
    Status:
    Published
    DOI:
    10.1136/annrheumdis-2015-207751 - link to the publication
  5. Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
    Authors:
    Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.
    Academic press:
    Journal of Clinical Investigation (rok: 2018, tom: 129(3), strony: 1193-1210), Wydawca: American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/JCI123267 - link to the publication
  6. Impact of fibrinogen carbamylation on fibrin clot formation and stability
    Authors:
    Veronika Binder , Brith Bergum, Stéphane Jaisson, Philippe Gillery, Carsten Scavenius, Endy Spriet, Anne Karin Nyhaug, Helen M. Roberts, Iain L. C. Chapple, Annelie Hellvard, Nicolas Delaleu, Piotr Mydel
    Academic press:
    Thrombosis and Haemostasis (rok: 2017, tom: 117(5), strony: 899-910), Wydawca: Schattauer GmbH
    Status:
    Published
    DOI:
    10.1160/TH16-09-0704 - link to the publication
  7. Sjögren's syndrome patients with ectopic germinal centers present with a distinct salivary proteome
    Authors:
    Nicolas Delaleu Piotr Mydel Johan G. Brun Malin V. Jonsson Andrea Alimonti Roland Jonsson
    Academic press:
    Rheumatology (rok: 2016, tom: 55(6), strony: 1127-1137), Wydawca: Oxford
    Status:
    Published
    DOI:
    10.1093/rheumatology/kew013 - link to the publication

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