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Carbamylation as a modulator of immune response

2014/14/E/NZ6/00162

Keywords

Descriptors

  • NZ6_2: Immunologia kliniczna
  • NZ1_2: Biochemia
  • NZ3_1: Biologia komórki

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Piotr Mydel

Number of co-investigators in the project: 4

Call

SONATA BIS 4 – announced on 2014-06-16

Amount awarded
1 472 835 PLN
Project start date
2015-07-01
Project end date
2020-06-30
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Gel Doc EZ Imager.
  2. Inkubator CO2. Cost: 26 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Antibodies against carbamylated proteins are present in primary Sjögren's syndrome and are associated with disease severity.

    Authors:
    Bergum B, Koro C, Delaleu N, Solheim M, Hellvard A, Binder V, Jonsson R, Valim V, Hammenfors DS, Jonsson MV, Mydel P.
    Academic press:
    Annals of Rheumatic Diseases (year: 2015, volume: 75(8), pages: 1494–1500), Publisher: BMJ Journals
    Status:
    Published
    DOI:
    10.1136/annrheumdis-2015-207751 – link to the publication

  2. Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

    Authors:
    Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.
    Academic press:
    Journal of Clinical Investigation (year: 2018, volume: 129(3), pages: 1193-1210), Publisher: American Society for Clinical Investigation
    Status:
    Published
    DOI:
    10.1172/JCI123267 – link to the publication

  3. Impact of fibrinogen carbamylation on fibrin clot formation and stability

    Authors:
    Veronika Binder , Brith Bergum, Stéphane Jaisson, Philippe Gillery, Carsten Scavenius, Endy Spriet, Anne Karin Nyhaug, Helen M. Roberts, Iain L. C. Chapple, Annelie Hellvard, Nicolas Delaleu, Piotr Mydel
    Academic press:
    Thrombosis and Haemostasis (year: 2017, volume: 117(5), pages: 899-910), Publisher: Schattauer GmbH
    Status:
    Published
    DOI:
    10.1160/TH16-09-0704 – link to the publication

  4. Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

    Authors:
    A. Hellvard, L. Zeitlmann, U.Heiser, A.Kehlen, A.Nisteroi, H.U.Demuth, J.Koziel, N. Delelau, J.Potempa, P.Mydel
    Academic press:
    Scientific Reports (year: 2016, volume: 6, pages: NA), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep31441 – link to the publication

  5. Carbamylated LL-37 as a modulator of the immune response

    Authors:
    Koro C, Hellvard A, Delaleu N, Binder V, Scanevius C,, Bergum B, Glowczyk I, Roberts H, Chapple ILC, Grant MM, Rapala-Kozik M, Potempa J, Mydel P
    Academic press:
    Innate Immunity (year: 2016, volume: Vol. 22(3), pages: 218–229), Publisher: Sage
    Status:
    Published
    DOI:
    10.1177/1753425916631404 – link to the publication

  6. Sjögren's syndrome patients with ectopic germinal centers present with a distinct salivary proteome

    Authors:
    Nicolas Delaleu Piotr Mydel Johan G. Brun Malin V. Jonsson Andrea Alimonti Roland Jonsson
    Academic press:
    Rheumatology (year: 2016, volume: 55(6), pages: 1127-1137), Publisher: Oxford
    Status:
    Published
    DOI:
    10.1093/rheumatology/kew013 – link to the publication

  7. Effects by periodontitis on pristane-induced arthritis in rats

    Authors:
    Eriksson K, Lönnblom E, Tour G, Kats A, Mydel P, Georgsson P, Hultgren C, Kharlamova; N, Norin U, Jöonsson J, Lundmark A, Hellvard A, Lundberg K, Jansson L, Holmdahl R, Yucel-Lindberg T
    Academic press:
    Journal of Translational Medicine (year: 2016, volume: 0,799305555555556, pages: NA), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12967-016-1067-6 – link to the publication

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Graphic design and implementation: Jakub Piotrowski