Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of heme oxygenase-1 in monocyte- and macophage-mediated progression of ischemic heart disease

2014/14/E/NZ1/00139

Keywords:

miRNAs heme oxygenase-1 inflammation myocardial infarction

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Jaźwa-Kusior 

Number of co-investigators in the project: 3

Call: SONATA BIS 4 - announced on 2014-06-16

Amount awarded: 1 865 000 PLN

Project start date (Y-m-d): 2015-05-05

Project end date (Y-m-d): 2021-03-04

Project duration:: 70 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do pomiarów mikrokrążenia za pomocą analizy kontrastu obrazu spekli laserowych (269 900 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Limb ischemia and vessel regeneration: Is there a role for VEGF?
    Authors:
    Agnieszka Jazwa, Urszula Florczyk, Anna Grochot-Przeczek, Bart Krist, Agnieszka Loboda, Alicja Jozkowicz, Jozef Dulak
    Academic press:
    Vascular Pharmacology (rok: 2016, tom: 86, strony: 18-30), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.vph.2016.09.003 - link to the publication
  2. Modulation of the monocyte/macrophage system in heart failure by targeting heme oxygenase-1.
    Authors:
    Mateusz Tomczyk, Izabela Kraszewska, Jozef Dulak, Agnieszka Jazwa-Kusior
    Academic press:
    Vascular Pharmacology (rok: 2019, tom: 112, strony: 79-90), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.vph.2018.08.011 - link to the publication
  3. Splenic Ly6Chi monocytes contribute to adverse late post-ischemic left ventricular remodeling in heme oxygenase-1 deficient mice.
    Authors:
    Mateusz Tomczyk, Izabela Kraszewska, Krzysztof Szade, Karolina Bukowska-Strakova, Marco Meloni, Alicja Jozkowicz, Jozef Dulak, Agnieszka Jazwa
    Academic press:
    Basic Research in Cardiology (rok: 2017, tom: 112, strony: 39), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00395-017-0629-y - link to the publication
  4. Characterization of hepatic macrophages and evaluation of inflammatory response in heme oxygenase-1 deficient mice exposed to scAAV9 vectors
    Authors:
    Mateusz Tomczyk, Izabela Kraszewska, Robert Mąka, Agnieszka Waligórska, Józef Dulak J, Agnieszka Jaźwa-Kusior
    Academic press:
    PLoS One (rok: 2020, tom: 15, strony: e0240691), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0240691 - link to the publication
  5. Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors
    Authors:
    Izabela Kraszewska, Mateusz Tomczyk, Kalina Andrysiak, Monika Biniecka, Anne Geisler, Henry Fechner, Michał Zembala, Jacek Stępniewski, Józef Dulak, Agnieszka Jaźwa-Kusior
    Academic press:
    Molecular Therapy - Methods & Clinical Development (rok: 2020, tom: 17, strony: 1190-1201), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtm.2020.05.006 - link to the publication
  1. Cardiac repair after myocardial infarction - role of macrophages and heme oxygenase-1
    Authors:
    Tomczyk M, Kraszewska I, Kachamakova-Trojanowska N, Szade K, Dulak J, Jazwa-Kusior A
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Open Bio/ Wiley
    Data:
    konferencja 6-11 lipca 2019
    Status:
    Published
    DOI:
    link to the publication
  2. miRNA-regulated restriction of transgene expression to the heart is limited by interindividual variability in cardiac miRNA-122 level
    Authors:
    Kraszewska I, Tomczyk M, Biniecka M, Zembala M, Dulak J, Jazwa-Kusior A
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: FEBS Open Bio/ Wiley
    Data:
    konferencja 6-11 lipca 2019
    Status:
    Published
    DOI:
    link to the publication

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